Queens University, Canada
Myron R Szewczuk is Full Professor of Immunology and Medicine, Queen’s University, Kingston, Ontario Canada for the past 37 years. Dr Szewczuk’s recent research has focused on the role of glycosylation in receptor activation with a particular focus of Toll-like, nerve growth factor Trk, eGFR and insulin receptors. He has discovered a novel receptor-signaling platform and its targeted translation in multistage tumorigenesis.
Neuraminidase-1 (Neu1) has recently emerged as a central target in the sialidase-mediated regulation of tumorigenesis. Recent evidence indicates that Neu1 plays a much more profound role in human cancers than previously expected. In clinical setting its being essential that targeted therapies are to circumvent multistage tumorigenesis, which includes genetic mutations at the different growth factor receptors, tumor neovascularization, chemoresistance, immune-mediated tumorigenesis and the development of tissue invasion and metastasis. Firstly, the cell-surface molecular signaling platform will be described as controlling Neu1 sialidase activity, and discuss its relevance in cancer cell signaling. Second, the current understanding of Neu1 activity associated with cancer development will be summarized, and outline the key roles of Neu1 during various stages of tumorigenesis, including regulation of growth factor receptor signaling, control of Toll-like receptor (TLR) signaling and immune-mediated tumorigenesis, regulation of epithelial-mesenchymal transition (EMT), metastasis and acquired chemoresistance, and regulation of tumor vascularization.