Biography

After graduating from Tongji Medical University in Wuhan in 1983, Dr. Tan became a graduate student and studied liver pathology. Then he went to Essen University in Germany, sponsored by the Volkswagen scholarship, to study mesothelioma (1987-1990). After that, he participated in the Human Genome Project at Columbia University in New York (1990-1994). Subsequently, Dr. Tan was a resident and then a chief resident at Yale University Medical Center (1994-1998). He continued as an oncologic pathology fellow at Memorial Sloan-Kettering Cancer Center in New York (1998-1999). Dr. Tan was certified in AP and CP in 1998. He became an assistant professor at Roswell Park Cancer Center in Buffalo (1999-2004). He then worked as an associate professor at the University of Texas Health Center in Houston for two years before I joined MD Anderson Cancer Center in 2006. Dr. Tan was promoted to professor at MD Anderson in 2010, and became the first physician with Asia-heritage holding joint appointments in two clinical disciplines at MD Anderson . Sixty percent of his time is devoted to clinical services, and the rest is committed to research, education, and extramural activities. Dr. Tan’s research is focused on solid tumors, investigating potential biomarkers to assess survivorship and guide personalized medicine. Two of his \English books, Principles of Molecular Diagnostics and Personalized Cancer Medicine and Advances of Surgical Pathology in Gastric Cancer, have been translated into Chinese. Dr. Tan has published 200 peer-reviewed scientific articles and book chapters. Jointly, Dr. Tan has held three patents. He has frequently been invited to present at national and international conferences and seminars. Additionally, he has been invited to chair and co-chair conferences and sections of congresses. Furthermore, Dr. Tan has mentored numerous residents, fellows, and junior pathologists. As the senior medical consultant of Kingmed Medicine, Dr. Tan introduced ASCP to China in 2014, and he has been the honored director of the ASCP Training Center there. He serves on the CAP Committee of Molecular Marketing Panel. Dr. Tan has also served on the editorial board of eight peer-reviewed journals.

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Research Interest

PRESENTTITLE AND AFFILIATION PrimaryAppointment Professor,Department of Gastrointestinal (GI) Medical Oncology, Division ofPathology/Lab Medicine, The University of Texas MD AndersonCancer Center, Houston, TX Dual/Joint/AdjunctAppointment N/A CITIZENSHIP UnitedStates HOMEADDRESS 5411Huisache Street Houston,TX 77081 Phone:(713) 745-4977 Cell:(281) 468-7194 OFFICEADDRESS TheUniversity of Texas MD Anderson Cancer Center 1515Holcombe Blvd UnitNumber: 0085 Houston,TX 77030 RoomNumber: G1.3563A Phone:(713) 745-4977 Fax:(713) 745-1105 Email:dtan@mdanderson.org EDUCATION Degree-GrantingEducation TongjiMedical University, Wuhan, China, MD, 1983, Medicine PostgraduateTraining GraduateStudent, Pathology, Tongji Medical University, Wuhan, China,9/1983-8/1987 VisitingScholar/Post Doctor, Essen University School of Medicine, Essen,Germany, 8/1987-2/1991 ClinicalResidency, Pathology, Yale University Medical Center, New Haven, CT,7/1994-6/1997 ClinicalResidency, Chief Resident, Yale University Medical Center, New Haven,CT, 7/1997-6/1998 ClinicalFellowship, Oncologic Surgical Pathology Fellowship, MemorialSloan-Kettering Cancer Center, New York, NY, 7/1998-6/1999 CREDENTIALS BoardCertification Diplomate,U.S. National Board of Medical Examiners, 1/1993 U.S.Federal Medical Board Exam Certification, 12/1993 Diplomateof American Board of Pathology, combined Anatomic & ClinicalPathology, 5/1998 Licensures Active TexasState Board of Medical Examiners, TX, M4579, 8/2006-11/2019 Inactive NewYork State Medical License, NY, 214646-1, 7/1999-6/2006 EXPERIENCE/SERVICE AcademicAppointments VisitingScholar/ Post Doctor, Department of Pathology/Laboratory Medicine,Essen University School of Medicine, Essen, Germany, 8/1987-2/1991 ResearchAssociate, Columbia University Medical Center, New York, NY,4/1991-6/1994 AssistantProfessor, Division of Pathology/Lab Medicine, Roswell Park CancerInstitute, State University of New York at Buffalo, Buffalo, NY,7/1999-11/2004 AssociateProfessor, Division of Pathology/Lab Medicine, University of TexasHealth Science Center at Houston, Houston, TX, 12/2004-8/2006 AssociateProfessor, Department of Pathology/Laboratory Medicine, Division ofPathology/Lab Medicine, The University of Texas MD AndersonCancer Center, Houston, TX, 9/2006-8/2010 Professor,Department of Gastrointestinal (GI) Medical Oncology, Division ofPathology/Lab Medicine, The University of Texas MD AndersonCancer Center, Houston, TX, 9/2010-present AdministrativeAppointments/Responsibilities Directorof Immunohistochemistry Laboratory, Roswell Park Cancer Center,Buffalo, NY, 1/1999-12/2004 Director,Laser Microdissection Core Facility, Buffalo, NY, 1/1999-12/2004 TissueCore Committee, Director, University of Texas Health Science CenterMedical School at Houston, Houston, TX, 12/2004-8/2006 OtherAppointments/Responsibilities Member,Roswell Park Cancer Center-Thoracic Multidisciplinary Program,Buffalo, NY, 1/1999-12/2004 Member,RPCI Solid Tumor Multidisciplinary Program, Buffalo, NY,1/2000-12/2004 Member,RPCI Pathology Quality Assurance, Buffalo, NY, 1/2000-12/2004 Member,RPCI New York State Lung Cancer Screening Task Force, Buffalo, NY,1/2000-12/2004 Member,RPCI Translation Research Tissue Support Resource Advisory Committee,Buffalo, NY, 1/2001-12/2004 Member,RPCI Task Force for JCAHO Operative and Invasive Procedures, Buffalo,NY, 1/2001-12/2004 Member,RPCI Committee of Comprehensive Cancer Center Support Grant Program,Buffalo, NY, 1/2002-12/2004 Member,RPCI GI Cancer Study Group, Buffalo, NY, 1/2002-12/2004 Member,RPCI Liver Biology Study Group, Buffalo, NY, 1/2002-12/2004 Member,Colon Cancer Research Group Advisory Committee, RPCI, Buffalo, NY,1/2003-12/2004 Member,Memorial Hermann Hospital Cancer Committee, Houston, TX,12/2004-8/2006 StudentAdmission Committee, University of Texas Health Science CenterMedical School at Houston, Houston, TX, 1/2005-8/2006 CAPMember Market Research Panel, College of Academy of Pathologist,Chicago, 8/2010-present EndowedPositions N/A Consultantships RochePharmaceuticals, New Jersey, Consultant, 6/2000 WesternNew York Pathology Society, New York, Consultant, including personalconsultations for Pulmonary and Head & Neck Pathology,1/2002-12/2004 SouthwesternOncology Group Lung Program, Buffalo, New York, Consultant, 2003-2004 KingmedDiagnostics, Guangzhou, China, Consultant, 2015-present Sino-USABiomedical Platform, Houston, TX, Consultant, 2017-present Militaryor Other Governmental Service N/A InstitutionalCommittee Activities TumorBank Committee, Member, 1/2008-present OncologicPathology Fellowship Committee, Member MD Anderson CancerCenter, 1/2008-present CancerHuman Biobank and Biospeimens Group, NCI Bethesda, MD, Member,8/2009-present ClinicalRevenue Cycle Committee, Member MD Anderson Cancer Center,9/2009-present QualityImprovement Oversight Committee, Member MD Anderson CancerCenter, 9/2009-present InstitutionalBiosafety Committee, Member MD Anderson Cancer Center,9/2011-present ClinicalStudy Section Review Committee--Institutional Research GrantsProgram, Member MD Anderson Cancer Center, 9/2011-present HONORSAND AWARDS Dean'sList, Tongji Medical University, 1980 Dean'sList, Tongji Medical University, 1981 VolkswagenFoundation Medical Award, 1988 Awardof Appreciation for Dedication and Excellence, Yale UniversityMedical Center, 1995 MedicalPhotography Honor, American Society of Clinical Pathology, 1995 ResidentPresentation Award, Yale University Medical Center, 1995 MolecularBiology Award, American Society of Investigative Pathology, 1996 RoswellPark Alliance Foundation Award for Clinical Research, Roswell ParkAlliance Foundation, 2000 America'sRegistry of Outstanding Professionals, 2006 BestUSCAP Meeting Abstract Presentation, GI Pathology Society, 2009 Top5 Abstract, College of American Pathologists, 2009 HonoraryPresident, Macau Anti-Cancer Association, 2011 RESEARCH Grantsand Contracts Funded Co-Investigator,20%, Lung cancer and carcinogenesis of arsenic, R01-FReD-29368,NIH/NCI, PI - C Yang, 4/1/2010-3/31/2015, $1,180,800 ($236,000/year) PrincipalInvestigator, 10%, Institutional Research Grant, MD Anderson,7/1/2012-6/30/2014, $100,000 ($50,000/year) Pending Co-Investigator,KLF4 and Human Gastric Cancer, NIH/NCI, PI - Keping Xie, M.D.,9/1/2009-8/31/2014 PrincipalInvestigator, Epigenetic Abnormalities in Gastric Cancer, AmericanGastrointestinal Association Co-Investigator,3%, Phase I study of MK-0646 in combination with Gencitabine orGemcitabine+Erlotinib in advanced pancreatic cancer, NIH/NCI, PI -Milind Javle, M.D., $250,000 Other N/A Completed PrincipalInvestigator, Molecular pathology set-up, Research Award, RoswellPark Alliance Foundation, 1/1/2000-12/31/2001 Co-Investigator,10%, Role of Peroxiredoxin Proteins in Malignant Progression ofProstate Cancer, R01 CA, NIH, PI - Y. Park, Ph.D., 7/2001-6/2005 Co-Investigator,MSI in Colorectal Adenoma and Cancer, NIH/NCI, PI - G Anderson,3/1/2003-2/28/2006 Co-ProgramLeader, 10%, NCI Core Grant-Cancer Center Support Grant, P30CA016056-27, NIH, PI - D. Hohn, M.D., 6/2003-5/2008 Co-Investigator,10%, Lung Cancer Molecular Markers by Gender: An Intergroup Study,R01 CA106815-01, NIH/NCI, PI - C. Ambrosone, Ph.D., 4/2004-3/2008 NotFunded N/A Protocols Funded Collaborator,A Phase I Open-Label Dose Escalation Study to Assess the Safety andTolerability of the BikDD Nanoparticle in Patients with AdvancedPancreatic Cancer, 2007-0762, PI - Milind Javle, 2009-present PrincipalInvestigator, Molecular Alterations in Gastric Neoplasms, LAB07-0657,2009, PI's Unfunded PrincipalInvestigator, Characteristics of EBV-associated gastric cancer,LAB-07-711, 2007-present, Pl's start-up fund PrincipalInvestigator, Potential prognostic value of protein expressionprofile in gastric cancer, LAB-07-0592, 2007, PI's start-up fund PrincipalInvestigator, Significance of surgical radial margin of gastricadenocarcinoma, LAB07-0371, 2007, PI's start-up fund Patents and TechnologyLicenses Patents N/A TechnologyLicenses N/A Grant Reviewer/Service onStudy Sections Committeeof Comprehensive Cancer Center Support Grant, National CancerInstitute, Member, 2002-2003 HongKong Science Foundation, Cancer Study Section, Member, 2004-2005 FloridaState Department of Health Program Project Progress Report, FloridaState Department of Health, Member, 2005-present Jamesand Esther King Biomedical Research Program, Research Program,Member, 2005-present LytmosFoundation, Scientific Review, Reviewer, Scientific review of grants,2007-2010 PUBLICATIONS Peer-ReviewedOriginal Research Articles Ramnath R, Francisco J. Hernandez, Tan D, Huberman J, Nataraan N, Beck A, Hyland A, Todorov I, Brooks J, Belper G. MCM2 is an independent predictor of survival in patients with non small cell carcinoma. Journal of Clinical Oncology 19:4257-4266, 2000. Tan D, Joel A. Huberman, Andrew Hyland, et al. Mcm2-BM8: A novel diagnostic marker for early detection of premalignant squamous epithelial lesions. BMC Cancer 11:1-6, 2001. Wiseman SM, Loree TR,Hicks W, Rigual N, Winston J, Tan D, Anderson G, Stoler D. Anaplastic thyroid cancer evolved from papillary carcinoma: demonstration of anaplastic transformation utilizing the inter-simple sequence repeat polymerase chain reaction. Arch Otolaryngol Head Neck Surg 129:96-100, 2002. Zhu W, Beck AF, Zou H, Chervinsky D, Brooks J, Tan D. Loss of heterozygosity in primary lung cancer using laser capture microdissection and wave DNA fragment analysis techniques. Med Sci. Monit 8:95-99, 2002. Tan D, Li Q, Ramnath N, Beck A, Wiseman S, Al Salameh A, Brooks J, Bepler G, Anderson T. Prognostic relevance of the expression of p53 oncoprotein in non-small cell lung cancer. Anticancer Research 23(3):1665-1672, 2002. Tan D, Kirley S, Li Q, Ramnath N, Slocum HK, Brooks JS, Wu CL, Zukerberg LR. Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study. Hum Pathol 34(2):143-9, 2/2003. PMID: 12612882. Wiseman SM, Swede H, Stoler DL, Anderson GR, Rigual NR, Hicks WL, Douglas WG,Tan D , Loree TR. Squamous cell carcinoma of the head and neck in nonsmokers and nondrinkers: an analysis of clinicopathologic characteristics and treatment outcomes. Ann Surg Oncol 10(5):551-7, 6/2003. PMID: 12794022. Tan D, Li Q, Deeb G, Ramnath N, Slocum HK, Brooks J, Cheney R, Wiseman S, Anderson T, Loewen G. Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry study. Hum Pathol 34(6):597-604, 6/2003. PMID: 12827614. Harvey SR, Hurd TC, Markus G, Martinick MI, Penetrante RM, Tan D, Venkataraman P, DeSouza N, Sait SN, Driscoll DL, Gibbs JF. Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer. Clin Cancer Res 9(13):4935-43, 10/2003. PMID: 14581368. Jiang M, Anderson T, Nwogu C, Tan D. Pulmonary malignant granular cell tumor. World J Surg Oncol 1(1):22, 10/2003. e-Pub 10/2003. PMCID: PMC272934. Tan D, Deeb G, Wang J, Slocum HK, Winston J, Wiseman S, Beck A, Sait S, Anderson T, Nwogu C, Ramnath N, Loewen G. HER-2/neu protein expression and gene alteration in stage I-IIIA non-small-cell lung cancer: a study of 140 cases using a combination of high throughput tissue microarray, immunohistochemistry, and fluorescent in situ hybridization. Diagn Mol Pathol 12(4):201-11, 12/2003. PMID: 14639106. Zhao X, Deeb G,Tan D. Cystic hypersecretory hyperplasia with atypia of the breast. Archives of Pathol & Lab Medicine 127(9):389-391, 2003. Harvey SR, Markus G, Martinick MI, Penetrante R, Tan D, Venkataraman P, DeSouza N, Sait S, Driscoll D, Hurd T, Gibbs J. Evaluation of urinary plasminogen activator (uPA), its receptor (uPAR), matrixmetalloproteinase-9 (MMP-9), and von Willebrand Factor in pancreatic cancer. Clinical Cancer Research 9:4935-4943, 2003. Tan D, Deeb G, Wang J, Slocum H, Winston J, Wiseman S, Beck A, Sait S, Anderson T, Nwogu C, Ramnath N, Loewen G. HER-2/neu protein expression and gene alteration in stage I-IIIA non-small cell lung cancer: A study of 140 cases utilizing a combination of high throughput tissue microarray, immunohistochemistry and fluorescent in-situ hybridization. Diagnostic Molecular Pathology 12:223-235, 2003. Tan D, Kirley S, Li Q, Ramnath N, Slocum H, Brooks S, Wu C, and Zukerberg L. Loss of Cables Protein Expression in Human Non-Small Cell Lung Cancer. Human Pathol 34(2):143-149, 2003. Anderson TM, Dougherty TJ, Tan D, Sumlin A, Schlossin J, Kanter P. Photodynamic therapy for sarcoma pulmonary metastases: A preclinical toxicity study. Anticancer Res. 23(5):3713-3718, 2003. Ming J, Anderson T, Nwogu CM, Tan D. Pulmonary Malignant Granular Cell Tumor. A case report and literature review. World Journal of Surgical Oncology 1:22-25, 2003. Wiseman S, Swede H, Stoler DL, Anderson G, Rigual N, Hicks W,Tan D, Loree T. Squamous cell carcinoma of the head and neck in non-smokers and non-drinkers: An analysis of clinicopathologic factors and treatment outcomes. Annuals of Surgical Oncology 10(5):551-557, 2003. Tan D, Li Q, Deeb G, Ramnath N, Slocum H, Cheney R, Anderson T, Brooks J, Wiseman S, Loewen G. Thyroid Transcription Factor-1(TTF-1) Expression Prevalence and Its Clinical Implications in Non-Small-Cell Lung Cancer: A High-Throughput Tissue Microarray and Immunohistochemistry Study. Human Pathol 34(6):597-604, 2003. Tan D, Wiseman S, Zhou Y, Li Q, Ward P, Slocum HK, Alrawi S, Loree T, Hicks W, Rigual N, Anderson G, Stoler D. Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique. Diagn Mol Pathol 13(1):33-40, 3/2004. PMID: 15163007. Bateman NW, Tan D, Pestell RG, Black JD, Black AR. Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem 279(13):12093-101, 3/2004. e-Pub 1/2004. PMID: 14726538. Deeb G, Wang J, Ramnath N, Slocum HK, Wiseman S, Beck A, Tan D. Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry. Mod Pathol 17(4):430-9, 4/2004. PMID: 14739904. Khoury T, Lele S, Tan D. Pathologic quiz case: an asymptomatic 79-year-old woman with an abnormal Papanicolaou test. Adenoid basal carcinoma of the cervix. Arch Pathol Lab Med 128(4):485-6, 4/2004. PMID: 15043480. Alrawi SJ, Deeb G, Cheney R, Wallace P, Loree T, Rigual N, Hicks W, Tan D. Lipomatous hemangiopericytoma of the head and neck: immunohistochemical and DNA ploidy analyses. Head Neck 26(6):544-9, 6/2004. PMID: 15162357. Wiseman SM, Rigual NR, Hicks WL, Popat SR, Lore JM, Douglas WG, Jacobson MJ, Tan D, Loree TR. Parathyroid carcinoma: a multicenter review of clinicopathologic features and treatment outcomes. Ear Nose Throat J 83(7):491-4, 7/2004. PMID: 15372923. Aljada IS, Ramnath N, Donohue K, Harvey S, Brooks JJ, Wiseman SM, Khoury T, Loewen G, Slocum HK, Anderson TM, Bepler G, Tan D. Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer. J Clin Oncol 22(16):3218-29, 8/2004. e-Pub 7/2004. PMID: 15249585. Javle MM, Tan D, Yu J, LeVea CM, Li F, Kuvshinoff BW, Gibbs JF. Nuclear survivin expression predicts poor outcome in cholangiocarcinoma. Hepatogastroenterology 51(60):1653-7, Nov-Dec, 11/2004. PMID: 15532797. Hawthorn L, Stein L, Varma R, Wiseman S, Loree T, Tan D. TIMP1 and SERPIN-A overexpression and TFF3 and CRABP1 underexpression as biomarkers for papillary thyroid carcinoma. Head Neck 26(12):1069-83, 12/2004. PMID: 15515157. Koury T, Lele S, Tan D. Adenoid Basal Carcinoma of Uterine Cervix. Archives of Pathol & Lab Medicine 128(4):485-6, 2004. Deeb G, Wang J, Slocum H, Wiseman S, Ramnath N, Tan D. Altered E-cadherin (E-cad) and epidermal growth factor receptor (EGFR) expressions affect patient survival in non-small cell lung cancer (NSCLC). Modern Pathology 17(4):430-39, 2004. Loewen G, Reid M, Tan D, Klippenstein D, Grossman Z, Nava E, Hyland A, Raza S, Cummings M, Natarajan R, Mahoney M. Bimodality lung cancer screening in high- risk patients: a preliminary report. Chest 125(5):163S-4S, 2004. Bateman NW, Tan D, Pestell RG, Black JD, Black AR. Colon tumor progression is associated with altered function of KLF5. J Biochem Chem 279(13):12093-12101, 2004. Tan D, Wiseman S, Zhou Y, Li Q, Ward P, Malik D, Rigual N, Hicks W, Loree T, Anderson G, Stoler D. Definition of loss of heterozygosity at telometic 11q in oncogenesis of head and neck squamous cell carcinoma. Diagnostic Molecular Pathology 13(1):33-40, 2004. Loewen GM, Krauza M, Hyland A, Deeb G, Tan D. Detection of Epithelial Metaplasia and Dysplasia with Autofluorescence Bronchoscopy. Cancer Detection and Prevention 14(10):1102-8, 2004. Douglas W, Tracy E, Tan D, Yu J, Hicks W, Rigual N, Loree T, Wang Y, Baumann H. Development of head and neck squamous cell carcinoma is associated with altered cytokine responsiveness. Molecular Cancer Research 6:585-593, 2004. Collins Y, Tan D, Pejovic T, Mor G, Qian F, Rutherford T, Varma R, McQuaid D, Driscoll D, Jiang M, Deeb G, Lele S, Nowak N, Odunsi K. Identification of differentially expressed genes in clinically distinct groups of serous ovarian carcinomas using cDNA microarray. Int Journal of Molecular Medicine 14(1):43-53, 2004. Alrawi SJ, Deeb G, Loree T, Cheney R, Gallance P, Tan D. Immunohistochemistry and DNA ploidy analyses of lipomatous hemangiopericytoma. Head and Neck 26(6):544-9, 2004. Hernandez F, Tan D, Connolly G, Ramnath N. Multimodality therapy for thymic carcinoma (TCA): results of a 30-year single-institution experience. Am. J. Clin. Oncol 27(1):68-72, 2004. Javle M, Tan D, Yu J, LeVea C, Li F, Kuvshinoff B, Gibbs J. Nuclear survivin expression predicts poor prognosis in cholangiocarcinoma. Hepatogastroenterology 51:1653-57, 2004. Chu Q, Hurd T, Harvey S, Martinick M, Markus G, Tan D, Gibbs J, Loree T. Overexpression of Urinary Plasminogen Activator (uPA) Protein and mRNA in Thyroid Carcinogenesis. Diagnostic Molecular Pathology 13(4):241-246, 2004. Wiseman W, Chu Q, Hicks W, Rigual N, Popat S, Lore J, Douglas W, Tan D, Loree T. Parathyroid Carcinoma: A Multicenter Report of Clinicopathologic Characteristics and Treatment Outcomes. Ear, Nose & Throat Journal 83(7):491-494, 2004. Yang J, Tan D, Asch H, Swede H, Kirsten M. Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer. Lung Cancer 46(1):29-42, 2004. Hawthorn L, Varma S, Wiseman S, Loree T, Tan D. TMP1 and SERPIN-A Overexpression and TFF3 and CRABP1Underexpression as Biomarkers for Papillary Thyroid Carcinoma: A cDNA Microarray Study. Head and Neck 26(12):1069-1083, 2004. Aljada I, Ramnath N, Donahue K, Harvey S, Brooks J, Wiseman S, Slocum H, Loewen G, Thaer K, Anderson T, Bepler G, Tan D. Up-regulation of the tissue inhibitor of matrix metalloproteinase-1(TIMP-1) protein is associated with tumor progression of human non-small cell lung cancer. Journal of Clinical Oncology 22(16):3218-3229, 2004. Said M, Wiseman S, Yang J, Alrawi S, Douglas W, Cheney R, Hicks W, Rigual N, Loree T, Spiegel G, Tan D. Tissue eosinophilia: a morphologic marker for assessing stromal invasion in laryngeal squamous neoplasms. BMC Clin Pathol 5(1):1, 1/2005. e-Pub 1/2005. PMCID: PMC548265. Okada H, Kimura MT, Tan D, Fujiwara K, Igarashi J, Makuuchi M, Hui AM, Tsurumaru M, Nagase H. Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. Int J Oncol 26(2):369-77, 2/2005. PMCID: PMC2292801. Li F, Yang J, Ramnath N, Javle MM, Tan D. Nuclear or cytoplasmic expression of survivin: what is the significance? Int J Cancer 114(4):509-12, 4/2005. PMCID: PMC2829944. Alrawi SJ, Tan D, Stoler DL, Dayton M, Anderson GR, Mojica P, Douglas W, Hicks W, Rigual N, Loree T. Tissue eosinophilic infiltration: a useful marker for assessing stromal invasion, survival and locoregional recurrence in head and neck squamous neoplasia. Cancer J 11(3):217-25, May-Jun, 5/2005. PMID: 16053665. Ramnath N, Sommers E, Robinson L, Nwogu C, Tan D, Sharma A, Cantor A, Lawrence D, Simon G, Bepler G. Phase II study of neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small-cell lung cancer (NSCLC). J Clin Oncol 23(16_suppl):7277, 6/2005. Khoury T, Hurd T, Tan D. Phyllodes tumor with pseudoangiomatous stroma hyperplasia. Breast J 11(4):285-7, Jul-Aug, 7/2005. PMID: 15982399. Ling X, Yang J, Tan D, Ramnath N, Younis T, Bundy BN, Slocum HK, Yang L, Zhou M, Li F. Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC). Lung Cancer 49(3):353-61, 9/2005. PMCID: PMC2827179. Nwogu C, Tan D, McLean M. Diagnostic Dilemma: persistent superior mediastinal mass following treatment of Hodgkin's Lymphoma. Case Reports and Clinical Practice Review 6:128-130, 2005. Ling X, Wu J, Tan D, Ramnath N, Younis T, Bundy B, Slocum H, Yang L, Zhu M, Slocum H, Li F. Differential expression of survivin and its variants is inversely associated with disease relapse and patient survival in non-small cell lung cancer (NSCLC). Lung Cancer 49(3):353-61, 2005. Khoury T, Chadha K, Javle M, Donohue K, LeVea C, Iyer R, Okada H, Nagase H, Tan D. Expression of intestinal trefoil factor (TFF-3) in hepatocellular carcinoma. International Journal of Gastrointestinal Cancer 35(3):171-7, 2005. Okada H, Tan D, Kimura MT, Igarashi J, Masahiko. Frequent trefoil factor 3(TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinogenesis. International Journal of Oncology 26:369-77, 2005. Alrawi SJ, Stoler D, Tan D, Dayton M, Loree T, Rigual N, Bartos J, Khoury T, Nowak N, Anderson G. Genomic Instability, DNA Alterations and Tumor Eosinophilic Expression in Head and Neck Squamous Cell Carcinoma. Cancer Genomics & Proteomics 2:307-16, 2005. Tan D, Hou M, Lee SO, Lou W, Wang J, Trump DL, Gao AC. Interleukin-6 polymorphism is associated with more aggressive prostate cancer. Journal of Urology 174(2):753-6, 2005. Khoury T, Bolos L, McGrath B, Wang M, Cheney R, Tan D. Malignant glomus tumor, a case report and review of literature, focusing on its clinicopathologic features and immunohistochemical profile. American Journal of Dermatopathology 27(5):428-31, 2005. Tawk R, Tan D, Fenstermaster D. Melanotic Schwannoma with Drop Metastases to the Caudal Spine and High Expression of CD 117 (c-kit). Journal of Neuro-Oncology 71(2):151-6, 2005. Li F, Yang J, Ramnath N, Javle M, Tan D. Nuclear and/or cytoplasmic expression of survivin: What is the significance? International Journal of Cancer 114(4):509-12, 2005. Alrawi SJ, Tan D, Sullivan M, Winston J, Loree TR, Hicks W, Rigual N. Peripheral Primitive Neuroectodermal Tumor of the Mandible with Cytogenetic and Molecular Biology Aberrations. Journal of Oral and Maxillofacial Surgery 63(8):1216-21, 2005. Khoury T, Hurd T, Tan D. Phyllodes tumor with pseduoangiomatoid stromal hyperplasia. The Breast Journal 11(4):285-7, 2005. Alrawi S, Winston J, Tan D, Loree TR, Gibbs J, Hicks W, Rigual N, Lorè JM. Primary Adenocarcinoma of Cervical Esophagus. J Exp Clin Cancer Res 24(2):325-30, 2005. Tan D, Kraybill W, Cheney R, Khoury T. Retiform hemangioendothelioma: a case report and review of the literature. J Cutan Pathol 32(9):634-7, 2005. Nwogu CM, Hill H, Tan D, Demmy T, Takita H, MD, Anderson T. Surgical Outcomes of Solitary Fibrous Tumors of the Pleura. Clinical Pulmonary Medicine 12:42-45, 2005. Wiseman S, Tan D, Hill H. The double pylorus: an unusual endoscopic finding. Endoscopy 37(3):277, 2005. Alrawi S, Tan D, Stoler D, Dayton M, Anderson G, Mojica P, Douglas W, Hicks W, Rigual N, Loree T. Tissue eosinophilic infiltratinion: a useful marker for assessing stromal invasion, survival and locoregional recurrence in head and neck squamous neoplasia. Cancer Journal 11(3):217-25, 2005. Loewen GM, Tracy E, Blanchard F, Tan D, Yu J, Raza S, Matsui S, Baumann H. Transformation of human bronchial epithelial cells alters responsiveness to inflammatory cytokines. BMC Cancer 5:145, 2005. e-Pub 11/2005. PMCID: PMC1289280. Loewen G, Tracy E, Tan D, Yu J, Glenn S, Matsui S, Hawthorn L, Gaumann H. Transformation of human bronchial epithelial cells is associated with altered responsiveness to inflammatory cytokines. BMC Cancer 5:145-51, 2005. Zaid M, Wiseman S, Yang J, Hicks W, Loree T, Rigual N, Spiegel G, Tan D. Tumor-associated tissue eosinophils as a predictive marker for stromal invasion of head and neck squamous cell cancer. BMC Clinical Pathology 7(5):1-7, 2005. Yao JL, Madeb R, Bourne P, Lei J, Yang X, Tickoo S, Liu Z, Tan D, Cheng L, Hatem F, Huang J, Anthony di Sant'Agnese P. Small cell carcinoma of the prostate: an immunohistochemical study. Am J Surg Pathol 30(6):705-12, 6/2006. PMID: 16723847. Mojica-Manosa P, Rigual N, Tan D, Sullivan M. An unusual case of a metastatic adenocarcinoma of the rectum to the mandible: a case report and review of the literature. J Oral Maxillofac Surg 64(9):1436-9, 9/2006. PMID: 16916682. Alrawi SJ, Carroll RE, Hill HC, Gibbs JF, Tan D, Brenner BM, Nowak NJ, Swede H, Stoler DL, Anderson GR. Genomic instability of human aberrant crypt foci measured by inter-(simple sequence repeat) PCR and array-CGH. Mutat Res 601(1-2):30-8, 10/2006. e-Pub 6/2006. PMID: 16806294. Nwogu C, Fischer G, Tan D, Glinianski M, Lamonica D, Demmy T. Radioguided detection of lymph node metastasis in non-small cell lung cancer. Ann Thorac Surg 82(5):1815-20; discussion 1820, 11/2006. PMID: 17062254. Khoury K, Tan D, Wang J, Intengan M, Yang J, Alrawi S, Yan P, Byrd JC. : Inclusion of MUC1 (Ma695) in a panel of immunohistochemical markers is useful for distinguishing between endocervical and endometrial mucinous adenocarcinoma. BMC Clinical Pathology 6:1-7, 2006. Alrawi SJ, Schiff M, Carroll R, Dayton M, Gibbs JF, Stoler DL, Tan D, Berman K, Anderson GR. Aberrant Crypt Foci. Anticancer Research 26:7-19, 2006. Alrawi SJ, Carroll R, Dayton M, Gibbs JF, Stoler DL, Tan D, Berman K, Anderson GR. Aberrant Crypt Foci(ACF) and genomic instability. Mutation Research 61:30-8, 2006. Chadha K, Black J, Khoury T, Yu J, Gibbs JF, Iyer RV, Tan D, Brattain MG, Javle MM. Activated AKt and Erk Expression and Survival after Surgery in Pancreatic Carcinoma. Ann Surg Oncol. 13(7):933-39, 2006. Alrawi S, Stoler D, Tan D, Dayton M, Loree T, Gibbs J, Rigual N, Sait S, Khoury T, Hicks W, Anderson G. Genomic Instability, DNA Alterations and Tumor Eosinophilic Expression in Head and Neck Squamous Cell Carcinoma. Cancer Genomics & Proteomics 2:307-16, 2006. Ramnath N, Tan D, Li Q, Hylander B, Hyland A, Ryes L, Ferrone S. Is Downregulation of MHC Class I Antigen Expression In Human Non-Small Cell Lung Cancer Associated With Prolonged Survival? Cancer Immunology & Therapeutics 55(8):891-9, 2006. Oureshi KM, Raman AK, Tan D, Fakih MG. Leukemoid reaction in pancreatic cancer: a case report and review of the literature. Journal of Pancreas 7(6):631-4, 2006. Mojica P, Sullivan M, Loree T, Tan D, Hicks W, Rigual N. Malignant hypercalcemia associated with a parathyroid macrocyst and the early genesis of a giant cell tumor. American Journal of Otolaryngology 27(1):54-7, 2006. Mojica P, Rigual N, Tan D. Metastatic Adenocarcinoma of the Rectum to the Mandible; A Case Report. Journal of Oral and Maxillofacial Surgery 64(9):1436-9, 2006. Yang J, Ramnath N, Moysich KB, Asch HL, Swede H, Alrawi SJ, Huberman J, Geradts J, Brooks JS,Tan D. Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer 6:203-8, 2006. Nwogu C, Fischer G, Tan D, Glinianski M, Lamonica D, Demmy T. Radioguided Detection of Lymph Node Metastasis In Non-Small Cell Lung Cancer(Radioguided Lymph Node Staging). Ann Thorac Surg 82(5):1815-20, 2006. Yao J, Madeb R, Bourne P, Lei J, Yang X, Tickoo S, Liu Z, Tan D, Cheng L, Hatem F, Huang J, di Sant'Agnese A. Small Cell Prostate Carcinoma: An Immunohistochemical Study. American Journal of Surgical Pathology 30(6):705-12, 2006. Javle MM, Gibbs JF, Iwata KK, Pak Y, Rutledge P, Yu J, Black JD, Tan D, Khoury T. Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancer. Ann Surg Oncol 14(12):3527-3533, 12/2007. Loewen G, Natarajan N, Tan D, Nava E, Klippenstein D, Mahoney M, Cummings M, Reid M. Autofluorescence Bronchoscopy for Lung Cancer Surveillance Based on Risk Assessment. Thorax 62(4):335-40, 2007. Ailawadhi S, Nagase K, Jihnhee Y, Tan D, Black J, Brattain M, Javle M. Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma. Hepato-Gastroenterology 54:1339-44, 2007. Brown RE, Tan D, Taylor JS, Miller M, Prichard JW, Kott MM. Morphoproteomic confirmation of constitutively activated mTOR, ERK, and NF-kappaB pathways in high risk neuro-blastoma, with cell cycle and protein analyte correlates. Ann Clin Lab Sci 37(2):141-7, 2007. PMID: 17522369. Tan D. Morphoproteomics: A Novel Approach of Protein Profiling for Identifying Potential Therapeutic Targets in Cancer Patients. Int J Clin Exp Pathol 1(4):331-332;2007, 2007. Ahmed BH, Ahmed A, Tan D, Awad ZT, Al-Aali AY, Kilkenny J, Orlando FA, Al-Chalabi A, Crass R, Alrawi SJ. Post-laparoscopic cholecystectomy pain: effects of intraperitoneal local anesthetics on pain control--a randomized prospective double-blinded placebo-controlled trial. Am Surg 74(3):201-9, 3/2008. PMID: 18376682. Tan D, Ross WA. Colorectal polyps: clinical significance of endoscopic and pathologic correlation. Am J Clin Pathol 129(4):659-60; author reply 660, 4/2008. PMID: 18431859. Liang JJ, Kimchi ET, Staveley-O'Carroll KF, Tan D. Diagnostic and prognostic biomarkers in pancreatic carcinoma. Int J Clin Exp Pathol 2(1):1-10, 4/2008. PMCID: PMC2491391. *Orlando FA, Tan D, Baltodano JD, Khoury T, Gibbs JF, Hassid VJ, Ahmed BH, Alrawi SJ. Aberrant crypt foci as precursors in colorectal cancer progression. J Surg Oncol 98:207-13, 7/2008. PMID: 18623110. *Li W, Tan D, Zhang Z, Liang J, Brown R. Activation of Akt-mTOR/p70S6K pathway in angiogenesis in hepatocellular carcinoma. Oncology Reports 20(8):713-719, 2008. PMID: 18813808. *Truong C, Li W, Feng W, Cagle P, Khoury R, Alrawi S, Xie K, Yao J,Tan D. Alpha-Methylacyl-CoA Racemase Experssion is Upregulated in Gastric Cancer: A Study of 249 Cases. Int J Clin Exp Pathol 1(6):518-523, 2008. PMCID: PMC2480587. Tan D, Ross WA. Colorectal Polyps: Clinical significance of endoscopic and pathologic correlation. American J of Clinical Pathology 129:659-60, 2008. PMID: 1843185. Tan D, Zander DS. Immunohistochemistry for assessment of pulmonary and pleural neoplasms: a review and update. Int J Clin Exp Pathol 1(1):19-31, 2008. PMCID: PMC2480532. *Feng W, Brown RE, Trung CD, Li W, Wang L, Khoury T, Alrawi S, Yao J, Xia K, Tan D. Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappa B pathways in human gastric adenocarcinoma. Ann Clin Lab Sci 38(3):195-209, 2008. PMID: 18715846. Tan D. Morphoproteomics: a novel approach to identify potential therapeutic targets in cancer patients. Int J Clin Exp Pathol 1(4):331-2, 2008. e-Pub 1/2008. PMCID: PMC2480548. Liang JJ, Alrawi S, Tan D. Nomenclature, molecular genetics and clinical significance of the precursor lesions in the serrated polyp pathway of colorectal carcinoma. Int J Clin Exp Pathol 1(4):317-324, 2008. PMCID: PMC2480541. Liang J, Alrawi S, Fuller G and Tan D. Presacral Carcinoid Tumors Arising in Tailgut Cysts May Be Associated with Estrogen Receptor Status: Case Report and Review of the Literature. Int J Clin Exp Pathol 1(6):539-543, 2008. PMCID: PMC2480588. *Yang J, Li Y, Khoury T, Alrawi S, Goodrich DW, Tan D. Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer. Ann Clin Lab Sci 38(2):105-12, 2008. PMID: 18469354. *Li W, Cagle PT, Botero RC, Liang JJ, Zhang Z, Tan D. Significance of overexpression of alpha methylacyl-coenzyme A racemase in hepatocellular carcinoma. J Exp Clin Cancer Res 27(1):2-9, 2008. PMID: 18577240. Li W,Tan D, Zenali MJ, Brown RE. Constitutive activation of nuclear factor-kappa B (NF-kB) signaling pathway in fibrolamellar hepatocellular carcinoma. Int J Clin Exp Pathol 3(3):238-243, 1/2009. PMCID: PMC2836501. Khoury T, Alrawi S, Ramnath N, Li Q, Grimm M, Black J, Tan D. Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. Clin Lung Cancer 10(1):58-66, 1/2009. PMID: 19289374. Yin M, Hu Z, Tan D, Ajani J, Wei Q. Molecular epidemiology of genetic susceptibility to gastric cancer: focus on single nucleotide polymorphisms in gastric carcinogenesis. American Journal of Translational Research 1(1):44-54, 1/2009. PMCID: PMC2776284. Li Q, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor foxM1 expression in human gastric cancer angiogenesis and progression. Cancer Research 69(8):3501-3509, 4/2009. PMID: 19351851. Guan X, Zhao H, Niu J, Tan D, Ajani JA, Wei Q. The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol 9(1):77-83, 10/2009. PMCID: PMC2771032. Khoury T, Sait S, Hwang H, Chandrasekhar R, Wilding G, Tan D, Kulkarni S. Delay to formalin fixation effect on breast biomarkers. Mod Pathol 22(11):1457-67, 11/2009. e-Pub 9/2009. PMID: 19734848. Khoury T, Arshad A, Bogner P, Ramnath N, Zhang S, Chandrasekhar R, Wilding G, Alrawi S, Tan D. Apoptosis-related (survivin, Bcl-2), tumor suppressor gene (p53), proliferation (Ki-67), and non-receptor tyrosine kinase (Src) markers expression and correlation with clinicopathologic variables in 60 thymic neoplasms. Chest 136(1):220-8, 2009. PMID: 19318677. Truong CD, Feng W, Li W, Khoury T, Li Q, Alrawi S, Yu Y, Xie K, Yao J, Tan D. Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A. J Exp Clin Cancer Res 28(1):14-21, 2009. PMCID: PMC2642773. Hassid Vj, Orlando FA, Awad ZT, Tan D, Khoury T, Ahmed BH, Alrawi SJ. Genetic and molecular abnormalities in cholangiocarcinogenesis. Anticancer Res. 29(4):1151-6, 2009. PMID: 19414358. *Yin M, Tan D, Wei Q. Genetic variants of the XRCC1 gene and susceptibility to esophageal cancer: a meta-analysis. Int J Clin Exp Med 2(1):26-35, 2009. PMCID: PMC2680054. Alrawi S, Stoler D, Tan D, Loree T, Khoury T, Rigual N, Bartos J, Hicks W, Nowak N, Anderson G. Genomic Instability and Clinical parameters in Head and Neck Squamous Cell Carcinoma. Journal of Experimental and Clinical Cancer Research. e-Pub 2009. Guan X, Zhao H, Niu J, Tan D, Ajani JA, Wei Q. Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer. J Exp Clin Cancer Res 28:94-100, 2009. PMCID: PMC2717936. Smith KD, Tan D, Das P, Chang GJ, Kattepogu K, Feig BW, Skibber JM, Rodriguez-Bigas MA. Clinical significance of acellular mucin in rectal adenocarcinoma patients with a pathologic complete response to preoperative chemoradiation. Ann Surg 251(2):261-264, 2/2010. e-Pub 10/2009. PMID: 19864936. Veras E, Khurana H, Abadeer R, Tan D, Ayala A. Solitary synovial osteochondroma: a clinicopathologic review of five cases with radiographic correlation. Ann Diagn Pathol 14(2):94-99, 4/2010. e-Pub 2/2010. PMID: 20227014. Xu B, Thong N, Tan D, Khoury T. Expression of Thyroid Transcription Factor-1 in Colorectal Carcinoma. Appl Immunohistochem Mol Morphol 18(3):244-249, 5/2010. PMID: 20042854. Tan CH, Marcal L, Tan D, Patnana M. Magnetic resonance imaging diagnosis of iron overload in a leukemic patient after allogeneic hematopoietic stem cell transplantation. Transfusion 50(5):1113-7, 5/2010. e-Pub 1/2010. PMID: 20070618. Qiu J, Kulkarni S, Chandrasekhar R, Rees M, Hyde K, Wilding G, Tan D, Khoury T. Effect of delayed formalin fixation on estrogen and progesterone receptors in breast cancer: a study of three different clones. Am J Clin Pathol 134(5):813-9, 11/2010. PMID: 20959666. Al-Agha OM, Liu W, Chandrasekhar R, Wilding G, Tan D, Alrawi S, Khoury T. CD138 (Syndecan-1) in thymic tumors: correlation with various World Health Organization types and clinical outcome. Int J Clin Exp Pathol 3(3):280-287, 2010. PMCID: PMC2836505. Dhingra S, Li W, Tan D, Zenali M, Zhang H, Brown RE. Cell cycle biology of fibrolamellar hepatocellular carcinoma. Int J Clin Exp Pathol 3(8):792-7, 2010. e-Pub 11/2010. PMCID: PMC2993230. Qiu J, Kulkarni S, Chandrasekhar R, Rees M, Hyde K, Wilding G, Tan D, Khoury T. Effect of Delayed Formalin Fixation on Estrogen and Progesterone Receptors in Breast Cancer: A Study of Three Different Clones. Am J Clin Pathol 134(5):813-9, 2010. Khoury T, Malik D, Fan C, Tan D, Kulkarni S. Modified Alcian Blue Enhances the Intraoperative Diagnosis of Sentinel Lymph Node Metastasis in Invasive Lobular Carcinoma: a Prospective Study. Arch Pathol Lab Med 134(10):1513-1519, 2010. PMID: 20923308. Zenali MJ, Tan D, Li W, Dhingra S, Brown R. Stemness Characteristics of Fibrolamellar Hepatocellular Carcinoma: Immunohistochemical Analysis with Comparisons to Conventional Hepatocellular Carcinoma. Ann Clin Lab Sci 40(2):126-134, 2010. PMID: 20421623. Hu Y, Bandla S, Godfrey TE, Tan D, Luketich JD, Pennathur A, Qiu X, Hicks DG, Peters JH, Zhou Z. HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma. Mod Pathol 24(7):899-907. e-Pub 4/2011. PMID: 21460800. Feng W, Zhou Z, Peters JH, Khoury T, Zhai Q, Wei Q, Truong CD, Song SW, Tan D. Expression of insulin-like growth factor II mRNA-binding protein 3 in human esophageal adenocarcinoma and its precursor lesions. Arch Pathol Lab Med 135(8):1024-31, 8/2011. PMID: 21809994. Dhingra S, Feng W, Brown RE, Zhou Z, Khoury T, Zhang R, Tan D. Clinicopathologic significance of putative stem cell markers, CD44 and nestin, in gastric adenocarcinoma. Int J Clin Exp Pathol 4(8):733-41, 2011. Khoury T, Chandrasekhar R, Wilding G, Tan D, Cheney RT. Tumour eosinophilia combined with an immunohistochemistry panel is useful in the differentiation of type B3 thymoma from thymic carcinoma. Int J Exp Pathol 92(2):87-96, 2011. PMID: 21044186. Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology 142(3):531-42, 3/2012. e-Pub 12/2011. PMID: 22155367. Chen Z, Wang J, Zhang H, Liu D, Li Y, Xu Y, Tan D, Chen D, Zhao X, Wang G. Topo IIα gene alterations correlated with survival in patients with diffuse large B-cell lymphoma. Eur J Clin Invest 42(3):310-20, 3/2012. e-Pub 8/2011. PMID: 21880040. Xu K, Zhou L, Liang B, Niu L, Zheng X, Xu J, Yang D, Tan D, Xu K. Safety and accuracy of percutaneous core needle biopsy in examining pancreatic neoplasms. Pancreas 41(4):649-51, 5/2012. PMID: 22504382. Choy B, Bandla S, Xia Y, Tan D, Pennathur A, Luketich JD, Godfrey TE, Peters JH, Sun J, Zhou Z. Clinicopathological characteristics of high expression of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma. BMC Gastroenterol 12(1):146, 2012 Oct 18, 10/2012. Choy B, Bandla S, Xia Y, Tan D, Pennathur A, Luketich JD, Godfrey TE, Peters JH, Sun J, Zhou Z. Clinicopathologic characteristics of high expression of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma. BMC Gastroenterol 12:146, 2012. e-Pub 10/2012. PMCID: PMC3544684. Chen WC, Maru DM, Abraham SC, Tan D, Raju GS. Endoscopic clip tamponade of bleeding: a novel adjunct technique for endoscopic mucosal resection. Endoscopy 45(2):UCTN:E104-5. e-Pub 3/2013. PMID: 23526499. Zhai Q, Yan L, Tan D, Chen R, Sun J, Gao L, Dong MQ, Wang Y, Li C. Phosphorylation-coupled proteolysis of the transcription factor MYC2 is important for jasmonate-signaled plant immunity. PLoS Genet. 9(4):e1003422. e-Pub 4/2013. PMCID: PMCPMC3616909. Dong H, Guo H, Xie L, Wang G, Zhong X, Khoury T, Tan D, Zhang H. The metastasis-associated gene MTA3, a component of the Mi-2/NuRD transcriptional repression complex, predicts prognosis of gastroesophageal junction adenocarcinoma. PLoS One 8(5):e62986, 5/2013. PMCID: PMCPMC3643958. Xu Y, Ma H, Yu H, Liu Z, Wang LE, Tan D, Muddasani R, Lu V, Ajani JA, Wang Y, Wei Q. The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer. PLoS One 8(5):e64973, 5/2013. PMCID: PMCPMC3665554. Li Z, Zou X, Xie L, Dong H, Chen Y, WuX, Zhou D, Tan D, Zhang H. Prognostic Importance and Therapeutic Implications of PAK1, a Drugable Protein Kinase, in Gastroesophageal Junction Adenocarcinoma. PLoS One 8(11), 11/2013. Li Y, Liu Z, Liu H, Wang LE, Tan D, Ajani JA, Wei QY. ERCC1 and ERCC2 variants predict survival in gastric cancer patients. PLoS One 8(9):e71994, 2013. e-Pub 9/2013. PMCID: PMC3759385. Zhou G, Chiu D, Qin D, Niu L, Cai J, He L, Tan D, Xu K. Expression of CD44v6 and integrin-β1 for the prognosis evaluation of pancreatic cancer patients after cryosurgery. Diagn Pathol 8:146, 2013. e-Pub 9/2013. PMCID: PMC3846138. Li Y, Liu Z, Liu H, Wang LE, Onodera H, Suzuki A, Suzuki K, Wadhwa R, Elimova E, Sudo K, Shiozaki H, Estrella J, Lee JS, Song S, Tan D, Ajani JA, Wei Q. Potentially Functional Variants in the Core Nucleotide Excision Repair Genes Predict Survival in Japanese Gastric Cancer Patients. Carcinogenesis 35(9):142, 9/2014. e-Pub 7/2014. PMID: 24990617. Humphries B, Wang Z, Oom AL, Fisher T, Tan D, Cui Y, Jiang Y, Yang C. MicroRNA-200b targets protein kinase Cα and suppresses triple negative breast cancer metastasis. Carcinogenesis 35(10):2254-63, 10/2014. e-Pub 6/2014. PMCID: PMC4178468. Javle M, Li Y, Tan D, Dong X, Chang P, Kar S, Li D. Biomarkers of TGF-β signaling pathway and prognosis of pancreatic cancer. PLoS One 9(1):e85942, 2014. e-Pub 1/2014. PMCID: PMC3896410. Zhang Y, Ren H, Wang L, Ning Z, Zhuang Y, Gan J, Chen S, Zhou D, Zhu H, Tan D, Zhang H. Clinical impact of tumor-infiltrating inflammatory cells in primary small cell esophageal carcinoma. Int J Mol Sci 15(6):9718-34, 2014. e-Pub 5/2014. PMCID: PMC4100116. Zhou Z, Bandla S, Ye J, Xia Y, Que J, Luketich JD, Pennathur A, Peters JH, Tan D, Godfrey TE. Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies. BMC Gastroenterol 14:78, 2014. e-Pub 4/2014. PMCID: PMC3998234. F Liu, Y Zhang, D Shen, Tan D. Molecular features and diagnostics of Lynch syndrome colorectal cancer. Chinese Journal of Pathology 9:208-215, 2014. Wang Q, Liu H, Xiong H, Liu Z, Wang LE, Qian J, Muddasani R, Lu V, Tan D, Ajani JA, Wei Q. Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer. Mol Carcinog 54(6):449-58, 6/2015. e-Pub 12/2013. PMID: 24302553. Huber AR, Tan D, Sun J, Dean D, Wu T, Zhou Z. High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7. BMC Gastroenterol 15:80, 7/2015. e-Pub 7/2015. PMCID: PMC4495619. Shen R, Liu H, Wen J, Liu Z, Wang LE, Wang Q, Tan D, Ajani JA, Wei Q. Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer. Mol Carcinog 54(9):880-8, 9/2015. e-Pub 4/2014. PMID: 24756984. Zhou M, Zhao J, Tian M, Song S, Zhang R, Gupta S, Tan D, Shen H, Ferrari M, Li C. Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale 7(46):19438-47, 12/2015. PMCID: PMC4993020. Waters R, Agarwal A, Tan DT. a case report of cytomegalovirus-induced colitis with colonic perforation 2(2):106-110, 2015. Chang HR, Nam S, Kook MC, Kim KT, Liu X, Yao H, Jung HR, Lemos R, Seo HH, Park HS, Gim Y, Hong D, Huh I, Kim YW, Tan D, Liu CG, Powis G, Park T, Liang H, Kim YH. HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. Gut 65(1):19-32, 1/2016. e-Pub 11/2014. PMCID: PMC4717359. Holmes M, Tan DT . Non-type A autoimmune gastritis in a patient with IgA deficiency. Am J Digest Dis 3(1):6-10, 2016. Feihu Yan, Jiayin Liu, Xiaoyi Huang, Yan Liu, Ci Zhao, Zhiwei Li, Tan D, Yanqiao Zhang, and Yingwei Xue. Title Polymorphisms at the microRNA binding sites of CASP3 and CASP7 contribute to gastric adenocarcinoma susceptibility in the northeastern China population. Scientific Reports. e-Pub 2016. Cui J, Yang L, Guo L, Shao Y, Tan D, Li N, Zhang H. The combination of early treatment response and ypT stage is a novel metric to stage rectal cancer patients treated with neoadjuvant chemoradiotherapy. Oncotarget 8(23):37845-37854, 6/2017. PMID: 28103579. Xia M, Xie Y, Zan L, Reddy S, Tan C, Li J, Zhou D, Tan D. Membranous staining of β-catenin and E-cadherin expression in patients with gastric cancer. International Journal of Clinical and Experimental Pathology 10(8):8980-90, 2017. Zan L, Chen J, Tan D. Highly agglutinative staphylococcin therapy for malignant pleural effusions: a systematic literature review and meta-analysis. International Journal of Cancer Research & Therapy 3(1):1-11, 1/2018. Zan L, Zhang X, Tan D. Differential characteristics of right and left colon cancer. In Press. Cuijan, Fu S, Tan D, Lin L, Haizeng Z. The combination of early treatment response and ypTstage can refine the current TNM staging system for rectal cancer patients treated with neoadjuvant chemotherapy. Oncotarget. Submitted. Invited Articles N/A Editorials N/A Other Articles Tan D and Wu Z. Preliminary observation of the aflatoxin-induced liver neoplasms. Tongji Med. Acta, 1990. Tan D and Mansfield B. The role of mast cell in histogenesis of asbestosis. Essen Medicine, 1991. Tan D, Yesner R, Zou H. Differential diagnosis of diffuse pelvic mesothelioma by immunohistochemistry and electronic microscopy: Analysis of 23 cases, 1995. Abstracts Al-Kasspooles MF, Tan D, Nwogu CE, Kader ME, Anderson TM. Prognostic significance of host immune response in patients with operable lung cancer. Proceedings of American Society of Clinical Oncology. Journal of Clinical Oncology:S905, 2000. Zhou YT, Quinn P, Ward P, Malik D, Brooks J, Rustum Y, Tan D. Role of loss of heterozygosity(LOH) at 11q24.1-q25 in oncogenesis of head and neck squamous cell carcinoma. Modern Pathology 13(1):141A-823, 2000. Zhou YT, Malik D, Tan D. Role of Novel antibodies (A103 and calrentinin) in Diagnosis of renal tumors. Modern Pathology 13(1):105A-608, 2000. Bepler G, Todorov I, Ramnath N, Slocum H, Beck A, Brooks J, Loewen G, Hyland A, Humberman J, Tan D. Mcm2-A novel diagnostic marker for early detection of premalignant lesions of the lung. Proceedings of the American Association for Cancer Research,. Cancer Research 42(3), 3/2001. Aljada I, Malik D, Brooks J, Bepler G, Tan D. Association of reciprocal expression of MMP2/MMP-3 and TIMP-1 with tumorogenesis of non-small cell lung cancer. Modern Pathology 14:216A-1272, 2001. Jun Y, Tan D, Moysich K, Swede H, Bepler G, Michalek A, Asch H. Cigarette Smoking and Gelsolin Expression in Non-Small Cell Lung Cancer. Cancer Research 42:37-195, 2001. Al-Mudhafer S, Al-Salameh A, Ryes L, Ramanth N, Anderson T, Tan D. Decreased expression of p16 and p27 in non-small cell lung carcinoma(NSCLC) associated with unfavorable clinical outcome. Modern Pathology 14:216A-1272, 2001. Zaid M, Loree M, Tan D. Eosiniphils as a predictive marker for stromal invasion of Head and neck squamous cell carcinoma. Modern Pathology 14:153A-896, 2001. Zhu W, Malik D, Beck A, Brooks J, Belper G, Tan D. Loss of heterozygosity of chromosome 3 in non-small cell carcinoma of lung using laser capture microdissection and DNA fragment wave techniques. Modern Pathology 14:237A-1402, 2001. Ramnath N, Hernandez F, Tan D, Huberman J, Natarajan, Beck A, Hyland A, Bepler G. MCM2 is an independent predictor of survival in patients with non-small cell lung cancer (NSCLC). Lung Cancer:327A-1304, 2001. Anderson TM, Litwin AM, Nwogu CE, Pelow JL, Tan D. Pulmonary tumorlets associated with non-small cell lung cancer. American J Surgery:224S, 2001. Said M, Al-Salameh, Malik DA, Cheney RT, Tan D. Revisitation and utilization of MART- 1(A03) and micropthalmia transcription factor (Mitf) in tumors of neural crest origin. , 2001. Wiseman S, Loree T, Hicks W, Riguel N, Tan D, Anderson G, Stoler D. Variability of Intratumoral Genomic Instability In Thyroid Cancer: An Insight into Thyroid Tumorigenesis and Evolution. poster presentation at COSM 2002, Boca Raton, Florida, U.S.A., 5/2002. Wiseman S, Loree T, Hicks W, Rigual N, Winston J, Tan D, Anderson G, Stoler D. Anaplastic Thyroid Cancer Evolved From Papillary Carcinoma: Demonstration Of Anaplastic Transformation Utilizing The Inter-simple Sequence Repeat Polymerase Chain Reaction. Educational Consortium Genetics In Oncology Workshop, Stevenson, Washington, 6/2002. Tan D, Ramnath N, Ibramhi A, Donathe K, Bepler G, Slocum H, Loewen G, Anderson T. Overexpression of the tissue inhibitor of metalloproteinease-1(TIMP-1) protein is a putative prognostic marker in non-small cell lung cancer. ASCO Molecular Therapeutics Symposium, San Diego, 11/2002. Loewen G, Krauza M, Hyland A, Deeb G, Tan D. Detection of premalignant bronchial epithelial abnormalities in high-risk patients. Journal of Clinical Oncology 21:447A-1784, 2002. Mudhafer SA, Al-Salameh A, Zou HH, Ramnath N, Anderson T, Brooks JJ, Tan D. Downregulation of p21(WAF1) in carciogenesis and prognosis of non-small cell lung cancer. Laboratory Investigation 82(1):325A-1355, 2002. Yang J, Swede H, Malik D, Moysich K, Asch H, Brooks J, Tan D. Prognostic Significance of Gelsolin Expression in Non-small Cell Cancer. 91st Annual Meeting of United States and Canadian Academy of Pathology Laboratory Investigation 82(1):330A-1377, 2002. Cheng CC, Pendyala L, Toth K, Tan D, ZXia Z, Petrelli N, Leichman L and G Leichman. Thymidine phosphorylase(TP) and thymidylate synthetase(TS) mRNA and protein expression in colorectal cancer. Cancer Research 43:1090, 2002. Bateman NW, Tan D, Black JD, Black AR. Altered function of KLF5 is associated with colorectal tumor progression. Digestive Disease Week, Orlando, Florida, 5/2003. Loewen G, Eracy M, Reid S, Natarajan RR, Tan D, Baumann H. A method for determination of the cytokine response of cultured premalignant bronchial epithelial cells. Second Annual International Conference on Frontiers in Cancer Prevention Research Conference, Phoenix, AZ, 10/2003. Tan D, Li Q, Deeb G, Slocum HK, Ramnath N, Loewen G, Wiseman S, Beck A, Anderson T, Brook JJ. A High-Density Tissue Microarray (TMA) and Immunohistochemistry (IHC) Study of Thyroid Transcription Factor-1(TTF-1) Expression in Non-Small-Cell Lung Cancer (NSCLC). 92nd United States and Canadian Pathology Annual Meeting, Washington, D.C. Modern Pathology 16(1):A-1438, 2003. Deeb G, Wang J, Ramnath N, Slocum H, Wiseman S, Beck A, Tan D. Altered E-cadherin (E-cad) and epidermal growth factor receptor (EGFR) expressions affect patient survival in non-small-cell lung cancer (NSCLC). Proceedings of American Society of Clinical Oncology, JCO 22,671:2700, 2003. Tan D, Wiseman S, Li Q, Slocum HK, Loree T, Hicks W, Rigual N, Stoler D, Anderson G. Definition of a Region of Loss of heterozygosity (LOH) at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique. 92nd United States and Canadian Pathology Annual Meeting, Washington, D.C. Modern Pathology 16(1):A-1016, 2003. Loewen G, Krauza M, Hyland A, Klippenstein D, Tan D. Detection of premalignant bronchial epithelial abnormalities in high-risk patients. Correlate LIFE with histology findings. Annual Meeting of American Pulmonary Society. Chest, 2003. Tan D, Li Q, Ramnath N, Slocum HK, Wiseman S, Beck A, Anderson T, Loewen G. Evaluation of Her-2/neu protein expression and gene alteration in stage I-IIIA non-small cell lung cancers and in non-neoplastic lung tissue: A survey study using combination of high throughout tissue microarray, immunohistochemistry, and fluorescent in-situ hybridization. AACR Annual Meeting. American Association for Cancer Research Annual Meeting Proceedings, Cancer Research 44(9):2531, 2003. Wiseman S, Tan D, Deeb G, Rajput A. Granulocytic sarcoma of the gastrointestinal tract, ASCO 39th Annual Meeting, Chicago, Illinois, U.S.A. Proceedings of ASCO 22,365:1464, 2003. Wiseman S, Stoler D, Anderson, Riguel N, Hicks W, Tan D, Loree T. High Rates Of Intrachromosomal And Chromosomal Instability In Papillary Thyroid Carcinoma Correlates With Aggressive Biological Behavior. AACR Annual Meeting. American Association for Cancer Research Annual Meeting Proceedings, Cellular, Molecular and Tumor Biology 44(107):5975, 2003. Anderson TM, Dougherty TJ, Tan D, Sumlin A, Schlossin JM, Kanter PM. Photodynamic therapy for sarcoma pulmonary metastases: a preclinical canine study. 39th Annual Meeting of the Society of Thoracic Surgeons, Annuls of Thoracic Surgery, 2003. Tan D, Piao YC, Li Q, Slocum HK, Younis T, Wiseman S, Brooks JJ, Li FZ , Ramnath N. Significance of Survivin Expression in Non-Small-Cell Lung Cancer(NSCLC): A Tissue Microarray Study. Modern Pathology 16(1):A-1437, 2003. Wiseman S, Zaho J, Winston J, Tan D, Stoler D, Anderson G, Rigual NR, Hicks WL, Loree TR. Immunohistochemical Expression of CA19-9 in papillary thyroid carcinoma: A potential marker for biologically aggressive disease. American Society of Cancer Research Annual Meeting, Orlando, FL, 3/2004. Tan D, Hou M, Lee SO, Lou W, Wang J, Trump DL, Gao A. Interleukin-6 polymorphism and risk of development of advanced prostate cancer. American Society of Cancer Research Annual Meeting, Orlando, FL, 3/2004. Wiseman SM, Reidy J, Swede H, Loree T, Rigual N, Hicks W, Huberman J, Tan D, Winston J. MCM2: Test of Utility as a Molecular Marker in Advanced Stage Oropharyngeal Carcinoma. Proceedings of the American Society of Clinical Oncology 2004 Annual Meeting, New Orleans, Louisiana, U.S.A., 6/2004. Khoury T, Orozco A, Intengan M, Nava MER, Tan D. A Defined Panel of Markers (Villin, Thyroid Transcription Factor-1, CD56, and CD57) is Useful in Differentiating the Primary Site of Neuroendocrine Carcinoma. American Journal of Clinical Pathology 122(643) (#53), 2004. Martinick M, Khoury T, Tan D, Geradts J, Markus G, Gibbs J, Harvey S. Expression of a Truncated Urokinase (UK) in Disulfide Complex with Haptoglobin (Hp) and a Neural Cell Adhesion-Like Molecule (NCAM) in Human Colon Cancers. Presented at the 3rd EORTC International Meeting on Cancer Molecular Markers. April 2004-Brussels, Belgium. The International Journal of Biological Markers, 19-S3, 2004. Khoury T, Intengan M, Wang J, Winston J, Tan D. MUC-1 (Ma695) Immunostain Distinguishes Between Mucinous Carcinoma of Endometrial and Endocervical Origin. Poster and oral presentation at The American Society of Clinical Pathology meeting San Antonio, TX 122:627-628, 2004. Kim M, Tan D, LeVea C, Yu J, Kuvshinoff B, Suneetha D, Gibbs J, Javle M. Nuclear survivin expression correlates with poor prognosis in cholangiocarcinoma. Annual Meeting of American Society of Clinical Cancer Research, New Orleans, LA, 2004. Alrawi S, Hicks W, Rigual N, Loree T, Tan D. Tissue Eosinophilia: A Valuable Morphologic Marker in Assessing Stromal Invasion, Locoregional Recurrence and Distant Metastasis in Head & Neck Squamous Cell Carcinoma. 93rd Annual Meeting of United States and Canadian Academy of Pathology, Modern Pathology 17(1):220A-927, 2004. Alrawi S, Stoler D, Tan D, Gibbs J, Anderson G. Genomic instability of aberrant crypt foci and colon cancer surveillance. The 66th Annual Meeting of Surgery, Nashville, Tennessee, 2/2005. Khoury T, Wang J, Tan D. Eukaryotic Initiation Factor-4E (eIF-4E) and Cyclin D1 expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry. American Association of Cancer Research, Anaheim, CA, 4/2005. Sommers E, Ramnath N, Robinson L, Tan D, Belper G. Neoadjuvant chemotherapy with gemcitabine and vinorelbine in resectable non-small-cell lung cancer(NSCLC). Lung Cancer 49 Supplement:S96-97, 7/2005. Nwogu C, Fischer G, Tan D, Glinianski M, Lamonica D, Demmy T. Radioguided Detection of Lymph Node Metastasis In Non-Small Cell Lung Cancer (Radioguided Lymph Node Staging). Southern Thoracic Surgical Association, Orlando, FL, 11/2005. Foster J, Black J, Khoury T, Levea C, Tan D, Donohue K, Chadha K, Gibbs J, Javle M. COX-2 expression and activation of EGFR pathway are common in hepatocellular carcinoma. Proc GI American Society of Clinical Oncology(abstract 125), 2005. Wang Y, Barbour K, Clements JL, Shrikant P, Tan D, Erin Tracy, Huntoon K, Lim SK, Berger FG, Baumann H. Haptoglobin, a major acute phase plasma protein in the mouse, promotes lymphopoiesis and function of the immune cells. , 2005. Chadha K, Khoury T, Levea C, Nagase H, Okada H, Tan D, Javle MM. Intestinal trefoil factor expression in hepatocellular carcinoma. Proc GI American Society of Clinical Oncology(abstract 119), 2005. Ailawadhi S, Khoury T, Levea C, Javle M, Kuvshinoff B, Okada H, Black J, Brattain M, Tan D. Intestinal trefoil factor (TFF-3) expression and correlation with other signaling proteins in cholangiocarcinoma. Proc GI American Society of Clinical Oncology(abstract 154), 2005. Alrawi S, Stoler D, Tan D, Swede H, Wiseman S, Rigual N, Loree T, Anderson G. Tissue Eosinophia, Genomic Instability and Clinicopathological Parameters in Papillary Thyroid Cancer. Society of Surgical Oncology(24-5), 2005. Alrawi S, Stoler D, Carroll R, Tan D. New Parameters in Risk Stratification in Papillary Thyroid Carcinoma: Eosinophilic Infiltration Gl. ORAL PRESENTATION at SSO's 59th Annual Cancer Symposium, San Diego, CA, 3/2006. Seiwert T, Bracht L, Ferguson B, Janamachi V, Ramasamy J, Husain A, Padilla M, Li Q, Tan D, Papathanassiu A, Salgia R. HSP27-a novel prognostic marker and therapeutic target for non-small cell lung cancer. AACR Annual Meeting, Washington D.C., 4/2006. Tan D, Khoury T, Chadha K, Yu J, Black J, Kuvshinoff B, Brattin M, Javle M. Activated Akt and Erk Expression in Inversely Associated with Survival of Patients with Pancreatic Carcinoma. College of American Pathologist Annual Meeting, San Diego, CA, 2006. Khoury T, Wang J, Slocum H, Tan D. Eukaryotic Initiation Factor-4E (eIF-4E) and Cyclin D1 expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry. Mod Pathol 19(1):311A, 2006. Alrawi S, Stoler D, Tan D, Wiseman S, Rigual N, Loree T, Anderson G. Glutathione S Transferase and Molecular and Clinicopathological Parameters in Papillary Thyroid Cancer. Society of Surgical Oncology, 2006. Yan P, Byrd J, Alrawi S, Khoury T, Wei L, Tent W, Flynn S, Tan D. Mucin Phenotype of Pancreatic Carcinoma and Non-Neoplastic Pancreatic Tissue: Its Diagnostic Utility in FIne Needle Aspiration (FNA) Specimens. 14th International Academic Pathology Meeting, Montreal, Canada, 2006. Gomez GM, Tan D, Zander DS, Castro CY, Sienko AG, Haque AK, Barrios RJ, Allen TC, Singhal NA, Cagle PT. Myoepithelial and Salivary Duct Differentiation Markers in Non-Small Cell Lung Cancer. Laboratory Investigation 86(1):308A, 2006. Alrawi SJ, Carroll R, Dayton M, Tan D, Gibbs J, Stoler D, Anderson G. New parameters in aberrant crypt foci evaluation in colon carcinogenesis (Glutathione S-Tranferase, B-RAF mutation, Genonmic Instability, Single Nucleotide Polymorphism (SNP) arrays). Journal of Surgical Research 130:163, 2006. Gomez EM, Tan D, Zander DS, Haque AK, Castro CY, Allen TC, Sienko AE, Barrios RJ, Singhal NA, Cagle PT. Pulmonary Neuroendocrine Tumors Can Express Markers of Myoepithelial and Salivary Duct Differentiation. Mod Pathol 19(1):308A, 2006. Alrawi SJ, Stoler D, Tan D, Gibbs J, Rigual N, Wiseman S, Loree T, Anderson G. Tissue Eosinophilia, Genomic Instability and Clincopathological Parameters in Papillary Thyroid Cancer. Annals of Surgical Oncology Supp Vol 13(2):S15, 2006. Seiwert T, Bracht L, Ferguson B, Janamachi V, Ramasamy J, Husain A, Padilla M, Li Q, Tan D, Papathanassiu A, Salgia R. HSP27-a significantly therapeutic target for non-small cell lung cancer. AACR Annual Meeting, Los Angels, CA, 4/2007. Brown R, Yao J, Javale M, Tan D. Constitutively Activated mTOR, ERK and NF-kappaB Pathways in Colorectal Cancer. Annals of America Society of Clinical Oncology, Chicago, IL, 5/2007. Malhotra RK, Li W, Cagle PT, Tan D. Immunohistochemical evaluation of expression and distribution pattern of novel vascular markers (CD105 and D2-40) in cirrhosis and hepatocellular carcinoma. 96th Annual Meeting of United States and Canadian Academy of Pathology, Modern Pathology 20(Suppl 2):1622A, 2007. Brown R, Tan D, Taylor J, Miller M, Prichard J, Kott M. Morphoproteomic Confirmation of Constitutively Activated mTOR, ERK and NF-kappaB Pathways in High Risk Neuroblastoma with Cell Cycle and Protein Analyte Correlates. 96th Annual Meeting of United States and Canadian Academy of Pathology, Modern Pathology 20(Suppl 2):1430A, 2007. Tan D, Yao J, Javle M, Law A, Brown R. Morphoproteomic Depiction of Constitutively Activated mTOR and ERK Pathways in Adenocarcinoma of the Large Intestin: A Pilot Study. Journal of CLinical Oncology 25(18S), 2007. Truong CD, Li W, Feng W, Cagle P, Khoury T, Alrawi S, Xia K, Yao J, Tan D. Alpha-Methylacyl-CoA Racemase (AMACR) is Upregulated in Gastric Cancer: A Study of 220 Cases. Mod Pathol 21(1):137A, 2008. Kundu UR, Li W, Tan D, Allen TC, Zhai QJ, Cagle PT. Alpha-methylacyl-co-a-racemase (AMACR) Expression Is a Biomarker of Poor Prognosis in Stage 1 and 2 Large Cell Carcinomas of the Lung. Mod Pathol 21(1):345A, 2008. Taggart MW, Wang H, Maru DM,Tan D, Rashid A. Appendiceal Mixed Carcinoid-Adenocarcinomas Share Better Prognosis Associated with Goblet Cell Carcinoid Tumors. Mod Pathol 21(1):137A, 2008. Fang X, Liu W, Iyer R, Tan D, Arnouk M, Ambuga B, Alrawi S, Khoury T. CD56 is Useful in Differentiating Foregut Gastrointestinal Neuroendocrine Tumors from Midgut or Hindgut and WHO Grade 1 from Grade 2 or 3 Tumors. College of American Pathologists, San Diego, CA, 2008. Truong CD, Feng W, Li W, Khoury T, Alwari S, Xia K, Yao J, Tan D. Characteristics of Epstein-Barr Virus-Associated Gastric Cancer: 20-Year Experience in a Single Medical Center. Mod Pathol 21(1):138A, 2008. Khoury T, Arshad A, Arnouk M, Tan D. D2-40, Mesothelin, Podoplanin and Other Mesothelioma-Ralated Marker in Thymic Tumors: A Tissue Microarray Analysis of 57 Cases. Mod Pathol 21(1):344A, 2008. Li W, Cagle P, Zhang Z, Tan D. Expression of α-Methylacyl Coenzyme A Racemase (AMACR/P504S) in Neoplastic and Nonneoplastic Liver Lesions. Mod Pathol 21(1):309A, 2008. Davis DW, Zhai QJ, Li W, Tan D, Allen TC, Popper HH, Cagle PT. Expression of Alpha-Methylacyl-COA Racemase (AMACR) in Tissue Microarray of 39 Cases of Diffuse Malignant Mesothelioma (DMM). Mod Pathol 21(1):340A, 2008. Truong C, Li W, Feng E, Cagle P, Khoury T, Alrawi S, Xie K, Yao J, Tan D. Expression of SOX9 and p63: A study of 200 cases to deternine their role in human gastric cancer. AACR Annual Meeting in San Diego, CA, 2008. Feng W, Li W, Truong C, Cagle P, Khoury R, Alrawi S, Xie K, Yao J, Tan D. Morphoproteomic Profile of mTOR, Ras/Raf kinase and NF-kB pathways in human gastric adnocarinomca. AACR Annual Meeting in San Diego, CA, 2008. Truong C, Li W, Feng W, Cagle P, Khoury T, Alrawi A, Xie K, Yao J, Tan D. Significance of HER-2/neu protein experssion and gene alteration in gastric cancer: A study of 208 cases using a combination of high throughput tissue microarray, immunohistochemistry, and fluorescent in-situ hybridization. AACR Annual Meeting in San Diego, CA, 2008. Li W, Tan D, Zhang Z, Brown RE. The Akt Pathway in Angiogenesis of Hepatocellular Carcinoma: A Immunohistochemical Stain Based Analysis. Mod Pathol 21(1):309A, 2008. Khoury T, Arshad A, Arnouk M, Alrawi S, Tan D. Thymoma: Immunohistochemistry Study with Emphasis on Lymphoid Markers (CD57, CD20, CD3, and CD5) and Clinicopathologic Correlati