Biography

Dr. Ian James Martins is an Editor/Reveiwer for Open Acess Pub/Open Access Journals/MDPI journals and various other international journals. Advisory Board Member for Photon Journal. Fellow of International Agency for Standards and Ratings (IASR). Conferred with the RICHARD KUHN RESEARCH AWARD-2015 ENDOCRINOLOGY AND METABOLISM. Chief Editor for International Journal of Diabetes Research (2014-2018), Research and Reviews: Neuroscience (2016-2018) and Journal of Diabetes and Clinical Studies (2017-2018). BIT Member (BIT Congress. Inc) with an H-index of 63, (ResearchGate (26) Scopus ID: 7103152779/Mendeley (21), UWA Research Repository (16). Scientist Science Advisory Board (USA), Academic with Academia.edu. Citations accumulated to >4551. Ian James Martins - Semantic Scholar https://www.semanticscholar.org/author/Ian-James-Martins/5258067. ResearchGate’s RG score > 96% INTERNATIONAL SCIENTISTS on www.google.com.au Ian James Martins. Certificates from Keynote addresses: Biomedicine 2018 (Osaka), Global Experts Meeting on Diabetes, Hypertension, Metabolic Syndrome 2018 (Melbourne), Laboratory Medicine 2018 (Berlin), Immunology World 2018 (Amsterdam), Innovate Pharma 2017 (Sydney), Innovate Neurology 2017, World Diabetes and Endocrinology Summit-2017 (Dubai) and Pharmacology and Ethnopharmacology 2016 (Chicago), AGHC2016 (Kaohsiung)..

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Research Interest

IMPACT OF PREVIOUS RESEARCH TO THE FIELD OF MEDICINE AND LABORATORY TECHNOLOGY THAT MAY AVOID INADVERTENT ERRORS AND MAY TRANSLATE TO COMMERCIALISATION OF MEDICAL RESEARCH THAT DETERMINE CRITICAL HEATLH OUTCOMES. Development of a BLOOD TEST has been of critical interest to the QUALITY CONTROL of plasma/sera samples for metabolic disease with relevance to diabetes and neurodegenerative diseases. RELEVANT PUBLICATIONS: 1. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215. CERTIFICATE OF PUBLICATION. 2. Evaluation of diagnostic tests in human health and disease. J Clin Path Lab Med. 2018;2(1):13-15. SIRTUIN 1 ANALYSIS ON BLOOD/PLASMA SAMPLES SHOULD BE CONDUCTED IN APPROPRIATE PRESERVATIVE, UNDER FREEZE/THAW CONDITIONS, STORAGE CONDITIONS. Bacterial LPS should be conducted (Sirtuin 1 repression) to avoid bacterial contamination with long term storage. ONLINE REFERENCES: 1. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol. 2017. 2. The Future of Biomarkers Tests and Genomic Medicine in Global Organ Disease. Arch Infect Dis Ther. 2017. 3. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016. 4. The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 5. LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research 2015. Dr Martins research with relevance to diet, diabetes and neurodegenerative diseases builds upon his past > 150 publications that generates outputs that will have relevant and significant impact to the global community. The incidence of diabetes and non alcoholic fatty liver disease (NAFLD) has been predicted to increase to 21% by 2050. Novel and critical elements of scholarly peer review provides information that the heat shock gene Sirtuin 1 is repressed with relevance to diabetes, neurological diseases and Alzheimer's disease. Major unsolved challenges to advances in biology may now provide evidence to reverse Sirtuin 1 dysfunction that is connected to primarily to heat shock protein metabolism and secondly to toxic amyloid beta metabolism with mitochondrial apoptosis in liver and brain cells. In the developing world increased levels of bacterial lipopolysaccharides repress the anti-aging gene Sirtuin 1 with the development of diabetes, neurodegenerative diseases and Alzheimer’s disease. Unhealthy diets accelerate Type 3 diabetes with the induction of NAFLD in Global Populations.Food and Nutrition cause liver and brain diseases with diabetes in the ...https://atlasofscience.org/food-and-nutrition-cause-liver-and-brain-diseases-with-diabe... Mar11,2016 Regulation of Body Temperature and NAFLD in Global Population. Feb 2018. Asian Hospital and Healthcare Management e-Newsletter. 62 INTERNATIONAL CERTIFICATES PRESENTED TO DR IAN JAMES MARTINS 1. CERTIFICATE, BEST ARTICLE, “Diet, Drug and Inhibitor Therapy prevent Toxic protein aggregation in various species” AS Nutritional Health, 2018 Volume 2 Issue 8. 2. CERTIFICATE, E-Poster participation, Insulin resistance and Cholesterol dyshomeostasis involve α-Synuclein and Amyloid beta interactions in Neurodegenerative diseases, 4th World Congress on Parkinsons and Huntington Disease, August 29-30, 2018, Zurich, Switzerland, Editors of the Journal of Neurological Disorders, Conference Series.com 3. Certificate of Recognition, Keynote Speaker, Antimicrobial drugs and bacterial amyloid beta peptide induce toxic manifestations to medical biology and pharmacotherapy, Conference Series and the Editors, Journal of Clinical and Experimental Pharmacology, Journal of Analytical and Bioanalytical Techniques and Journal of Clincal Trials, International Conference on Biomedicine and Pharmacology, August 06-07, 2018 4. Certificate of Recognition, Keynote presentation, Transcriptional dysregulation of Sirtuin 1 is relevant to Diabetes and Global Chronic Disease, Conference Series and the Editors of Journal of Diabetes & Metabolism, Journal of Diabetic Complications & Medicine and Journal of Hypertension, Global Experts Meeting on Diabetes, Hypertension, Metabolic Syndrome”held during July 30-31, 2018 in Melbourne, Australia 5. Biomedical and Pharmacology Journal, REVEIWER OF THE MONTH, Outstanding reviewer for his enexplicable contribution in safeguarding the academic integrity of the Journal. July, 2018. 6. Publication Certificate, Diet, Drug and Inhibitor Therapy prevent toxic protein aggregation in various species, Acta Scientific Nutritional Health, July, 2018 7. Certificate of Recognition, Keynote Speaker, “The Limitations of Laboratory Medicine with relevance to Biomarker tests and Global Organ Disease”, 13th International Conference on Laboratory Medicine and Pathology, June 25-26, Berlin, Germany, Conference Series and the Editors of Diagnostic Pathology: Open Access, Journal of Clinical and Experimental Pathology and the Journal of Molecular and Genetic Medicine. 8. Certificate, Editorial Board Membership, Journal of Studies on Diabetes 9. Review Certificate, Acta Scientific Nutritional Health (ASNH), May 2018 10. Certificate of Editorial Board Membership, REFERENCE NUMBER, ESCIPUB/IJOAR/2018-0011, INTERNATIONAL JOURNAL OF AGING RESEARCH 11. Certificate of Reviewing, Awarded October 2017, Journal of Functional Foods, In cooperation with International Society for Nutraceuticals and Functional Foods 12. Certificate of Recognition, Keynote Speaker, Entitled " Appetite control is involved in Immunotherapy with relevance to cardiovascular disease, NAFLD and Diabetes, Pulsus and Editors of Journals of Immune Disorders and Therapy, Journal of Immunodiagnostics and Journal of Immunopatholgy, 7th World Congress on Immunology, Amsterdam, Netherlands, April 19-20, 2018 13. Certificate of Recognition, Chairing Sessions on Vaccinology, Immunopathology, Immunotherapy, Immune Proteomics, Cancer and Tumour Oncology, 7th World Congress on Immunology, Amsterdam, Netherlands, April 19-20, 2018 14. Certificate of Recognition for Workshop Presentation, Keynote Speaker, Entitled "Diagnosis and Management of Immunological Diseases requires Sirtuin 1 as a Diagnostic protein marker, Pulsus and Editors of Journals of Immune Disorders and Therapy, Journal of Immunodiagnostics and Journal of Immunopatholgy, 7th World Congress on Immunology, Amsterdam, Netherlands, April 19-20, 2018, 15. Review Confirmation Certificate, MDPI Journals, 2017-2018. 16. Publication Certificate: “Biotherapy and the Immune System in Ageing Science”. Acta Scientific Nutritional Health 2.4 (2018): 29-31. 17. Certificate: Eminent Editor-in-chief for Journal of Diabetes and Clinical Studies 18. Publication Certificate, Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions MINIREVEIW. 6.4 (2018): 209-215. 19. Publication Certificate Article ENTITLED “Antimicrobial Drugs and Bacterial Amyloid Peptide Induce Toxic Manifestations in Chronic Diseases. EC Pharmacology and Toxicology 6.1 (2018): 01-04. 20. Publication Certificate ENTITLED “Appetite control and nutrigenomic diets are connected to immune regulation and diabetes prevention” EC Nutrition 12.3 (2017): 120-123. 21. Certificate for Exceptional Effort for Presentation entitled"Caffeine with Links to NAFLD and Accelerated Brain Aging", November 13-15, Macau, China 22. Certificate for Exceptional Effort for Presentation entitled"Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases", November 13-15, Macau, China 23. Certificate of Recognition, Editors of Journal of Clinical Epigenetics, Journal of Cancer Science and Therapy and Journal of Carcinogenesis and Mutagenesis thank Ian James Martins for Oral Presentation, Entitled “Single gene Inactivation with implications to Diabetes and Multiple Organ Dysfunction Syndrome” 2nd International Congress on Epigenetics and Chromatin, Nov 6-8, Frankfurt, Germany. 24. Certificate, Fellow, Directorate of Endocrinology and Metabolism, International Agency for Standards and Ratings (Lifetime Membership) 25. Certificate,Fellow, Directorate of Medical Science, International Agency for Standards and Ratings, Article entitled: Caffeine consumption with Relevance to Type 3 diabetes and accelerated brain aging, Winner at World Academic Championship-2017 in Medical Science 26. Certificate, Fellow, Directorate of Diabetes and Health, International Agency for Standards and Ratings (Lifetime Membership) Article entitled: Nutrigenomic Diets and Caffeine Determines the Intelligence Quotient and Thinking in Developing Countries, Winner at World Academic Championship-2017 in Diabetes 27. Certificate of Invitation, Dr. Martins has been invited to participate in the book project under the working title "Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment", ISBN 978-953-51-5579-9. InTech - Open Science Open Minds | InTechOpen 28. CERTIFICATE: Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer’s disease. Photon ebooks. UBN: 015-A94510112017Edition: I Impact Index: 4.1. Dr Ian Martins is conferred with the RICHARD KUHN RESEARCH AWARD-2015 ENDOCRINOLOGY AND METABOLISM, International Agency for Standards and Ratings 29. Certificate, Special Recognition, Pulsus WWW.PULSUS.COM, Organizing Committee Member, Microbiology and Pharmaceutical Microbiology 2017, 02-03, 2017, Atlanta, USA 30. Certificate of Recognition, Keynote Presentation, “Bacterial Lipopolysaccharides (LPS) accelerates Diabetes, Acute epilepsy and Neurodegenerative disease Pulsus and the Editors of Journal of Pharmacology and Medicinal Chemistry and Journal of Microbiology and Biotechnology Reports, 3rd International Congress on “Microbiology and Pharmaceutical Microbiology, 02-03,2017, Atlanta, USA 31. Certificate of Appreciation, Chairman, Sessions, Pulsus and the Editors of Journal of Pharmacology and Medicinal Chemistry and Journal of Microbiology and Biotechnology Reports, 3rd International Congress on “Microbiology and Pharmaceutical Microbiology, 02-03,2017, Atlanta, USA 32. Certificate of Recognition, ACS Publications Reveiwer, American Chemical Society 33. Certificate of Editorship, Open Access Pub, Editorial Board Member, Journal of Aging Research and Health Care 34. Certificate of Recognition, The Future of Biomarkers Tests and Genomic Medicine in Global organ disease, Global Summit on Clinical Research and Biomarkers, August 21-23,Dallas,USA, Scientific Federation Abode for Researchers 35. Publication Certificate, Calorie sensitive Anti-Aging gene regulates Hepatic amyloid beta clearance in Diabetes and Neurodegenerative diseases, Editor’s Column Article, EC Nutrition 36. Publication Certificate, Heat shock Gene dysregulation and Inactivation of Drug Therapy, Editor’s Column Article, EC Pharmacology and Toxicology 37. Certificate of Excellence in Reveiwing, Asian Journal of Medicine and Health 2017, SDI/HQ/PR/Cert/35265/Ian/ 38. BEST SPEAKER, DUBAI HEALTH CARE SUMMIT-2017, DUBAI, UNITED ARAB EMIRATES Certificate of Appreciation for PANEL MEMBER at the DUBAI HEALTH CARE SUMMIT-2017, WORLD DIABETES AND ENDOCRINOLOGY SUMMIT, DUBAI, UNITED ARAB EMIRATES 39. Certificate of Appreciation for KEYNOTE SPEAKER at the DUBAI HEALTH CARE SUMMIT-2017, WORLD DIABETES AND ENDOCRINOLOGY SUMMIT, DUBAI, UNITED ARAB EMIRATES 40. Certificate of Appreciation for KeyNote Speaker, Session Chair and Advisory Board Member, Innovate Conferences,2017, Caffeine consumption with Relevance to Type 3 diabetes and accelerated brain aging, June 14th. 41. Certificate of Appreciation for KeyNote Speaker, Session Chair and Advisory Board Member, Innovate Conferences 2017 Links between drug metabolism and insulin resistance in Global Communities International Summit on Pharma, Vaccines, Immunology-Business and Clinical Trials, June 12-13th,2017, Sydney Australia 42. Certificate of Publication, Bacterial LPS overrides adenosine treatment of Epileptic Seizures. EC Microbiology, 7; 3: 83-86. 43. Certificate for Exceptional Effort at the 1st International Biotechnology Congress (IBC-2017), April 25-27, 2017, (Xi'an, China). 44. Certificate of Appreciation, Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global Communities, International Conference on Genomic Medicine (Gene-Med 2017), Feb 22-24, Baltimore, MD, USA Certificate of Appreciation, 45. Certificate,Valuable Support Scientific Session Chairman, International Conference on Genomic Medicine (Gene-Med 2017), Feb 22-24, Baltimore, MD, USA 46. Elected Member of the European Centre for Research and Training and Development UK CERTIFICATE #5839 47. Certificate of Publication,"Drug-Drug interactions with relevance to drug induced mitochondrial toxicity and accelerated global chronic diseases” 2017,Vol 3;18-21.;EC Pharmacology and Toxicology 48. Certificate of Publication, “Early Diagnosis of Neuron Mitochondrial Dysfunction may Reverse Global Metabolic Neurodegenerative Disease”, World Global Journal of Medical Research, 16, 2, 2016, 33-40. 49. Certificate of Publication, “Diabetes and Organ Dysfunction in the Developing and Developed” World Global Journal of Medical Research: F Diseases Volume 15 Issue 1, 2015. INTERNATIONAL CERTIFICATES PRESENTED TO DR IAN JAMES MARTINS 50. Certificate for Invited Speaker at the World Gene Convention-2016, November 03-05, Shanghai, China, Overnutrition induced Neurotoxicity. 51. Certificate for Invited Speaker at the World Gene Convention-2016, November 03-05, Shanghai, China, Chylomicron remnant metabolism in human apo E transgenic mice. 52. Certificate of Recognition, 2nd International Conference and Expo on Lipids: Metabolism Nutrition and Health, October 03-05,2016, Orlando, USA Editorial Board Membership 53. CERTIFICATE, Research and REVIEWS: Neuroscience October, 2016 Certificate, 2nd Neurological Disorders Summit (NDS-2016) September 07-09, Baltimore, MD, USA 54. Certificate of Membership, Member of BIT Congress Inc 55. Certificate of Recognition, Key Note Speaker, 2nd International Conference and Exhibtion on Pharmacology and Ethnopharmacology, 2016, Chicago, 56. The First Invited Notable (Principal Research Fellow) Speaker at the PLENARY FORUM at the 4th Annual Global Health Conference-2016, Kaohsiung, Taiwan. Plenary Forum Presentation Attached as Conference Presentation, Title: Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer’s disease. This ORAL presentation at the AGHC-2016 is related to the scholarly publication in PHOTON but differ with relevance to the International Agency for Standards recognition of the written publication that is associated with the Richard Kuhn Research Award-2015 (Endocrinology and Metabolism) presented to Ian James Martins. 57. USA Strathmore’s Who's Who Certificate, Demonstrated Leadership and Achievement in their Occupation, Industry or Profession, SELECTED on the basis of the most INTELLIGENT children of the WORLD 1976-1980 58. Certificate, 6th World Gene Convention-2015, ORAL PRESENTATION Qingdao, China Certificate, 6th World Gene Convention-2015, POSTER PRESENTATION Qingdao, China 59. Certificate of Recognition, 6th Global Summit and Expo on Food and Beverages 2015, Orlando, USA 60. Certificate of Publication 2015, Global Journal of Medical Research, Global Journals Inc. USA 61. Certificate, Oral Presentation, 5th World Congress on Diabetes and Metabolism 2014, Embassy Suites Las Vegas, USA 62. Certificate, Poster Presentation, 5th World Congress on Diabetes and Metabolism 2014, Embassy Suites, Las Vegas, USA Research Activity Statistics have been provided by Publons with comparison to other researchers. Ian James Martins is now in the 98th percentile as assessed for Publons users by merit. Dr Ian Martins is a reviewer for approx. 47 journals over the past 5 years. INVITED CHAIR FOR INTERNATIONAL MEETINGS Chair: Vaccinology, Immunopathology, Immunotherapy, Immune Proteomics, Cancer and Tumour Oncology, 7th World Congress on Immunology, Amsterdam, Netherlands, April 19-20, 2018, Chair, Pipeline 1: Biotherapeutics for Diseases, Bit's 2nd International Congress of Biotherapy-2018 (Programme Committee Member), Chair and Advisory Board Member, Innovate Conferences 2017, Chair/Co-Chair at congress and conference series at the World Gene Convention-2016 (Shanghai, China, Pharmacology and Ethanopharmacology 2016 (Chicago, USA), Annual World Congress of Diabetes-2014 (Haikou, China), World Gene Convention-2014 (Haikou, China). Ian James Martins Editorships Updates in Nutritional Disorders and Therapy Editorial Board Member 2017 - 2020(3 years) Current Updates in Gerontology Editorial Board Member 2017 - 2020(3 years) EC Pharmacology and Toxicology Editorial Board Member 2017 - 2020(3 years) Journal of Ageing Research and HealthCare EDITOR 2015 - 2020(5 years) Annals of Neurodegenerative Disorders Editor 2018 - Present DISEASES, MDPI Journal (Neurosciences) Editor 2018 - Present Journal of Studies on Diabetes Editor (Certificate) 2018 - Present International Journal of Aging Research Editor (Certificate) 2018 - Present Journal of Psychiatry and Behavioral Health Forecas Editor 2018 - Present Neurology and Neurosugery Editor 2018 - Present Modern Clinical Medicine Research Editor 2018 - Present Journal of Clinical Nephrology Editor 2018 - Present EC Nutrition Honourable Editorial Board member 2017 - Present Novel Techniques in Nutrition and Food Sciences (NTNF) Editor 2017 - Present Global Journal of Endocrinology and Metabolism Editor 2017 - Present Research in Chronic Diseases Editor 2017 - Present Gerontology and Geriatrics Studies Editor 2017 - Present Journal of Genetic Disorders Editor 2017 - Present Journal of Diabetes and Clinical Studies Chief Editor (CERTIFICATE) 2017 - Present Degenerative Intellectual & Developmental Disabilities (DDID) Editor 2017 - Present Annals of Alzheimer's and Parkinson's Disease Editor 2017 - Present International Journal of Advances in Biology EDITOR 2016 - Present Annals of Obesity and Disorders EDITOR 2016 - Present SL Nutrition and Metabolism EDITOR 2016 - Present Research and Reveiws: Neuroscience Chief EDITOR (CERTIFICATE PROVIDED) 2016 - Present International Journal of Diabetes Research CHIEF EDITOR 2014 - Present Annals of Clinical Endocrinology and Metabolism Editor 2018 World Journal of Psychiatry and Mental Health Research Editorial Board Member 2017 - 2018(a year) Journal of Food Studies Editorial Board Member 2018-2021 Case Reports: Clinical, Medical and Surgical Editorial Board Member 2018-2021 CPQ Nutrition Editorial Board Member 2018-2021 Advancements in Case Studies Editorial Board Member 2018-2021 Biomedical and Pharmacology Journal Academic Qualifications B.Sc. 1984 University of Western Australia M.Sc. 1986 University of Western Australia Ph.D. 1989 University of Western Australia PAST Professional History Dr Martins completed his undergraduate Science degree at the University of Western Australia in 1984, then completing a MSc in Clinical Biochemistry in 1986. In 1987 he commenced a Ph D studying the role of high density lipoprotein (HDL) in diabetes (Hackett Scholarship). In 1993 he was awarded a Saw fellowship from the University of Western Australia to conduct studies relating to the metabolism of chylomicrons and their remnants and the influence of size and composition on their clearance from blood and its importance to atherosclerosis. The publications between 1988-2000 have shown that Dr Martins has made a valuable and solid contribution to the field of atherosclerosis and heart disease. His work has concentrated on understanding the role of dietary cholesterol rich particles and the subsequent clearance and metabolism from the blood plasma and their potential risk for the development of heart disease. These research studies have shown that the type of dietary fat and increased consumption are important risk factors for heart disease. Synopsis of Contribution to Research In Western countries a major current health problem is the high incidence of obesity and Type 2 diabetes and its associated risk for cardiovascular disease. Research studies conducted from the industry and medical research grants have shown that the type of dietary fat and increased consumption are important risk factors for heart disease. In 1994 as a Fellow and Consultant (UWA) working on a commercial grant from Inovax Ltd led to the development of a stable isotope breath test for dietary fat metabolism and and assessment of the predictive value of the test for heart disease. International patents have been have filed in various countries for the stable isotope breath test and oral Peptide delivery systems for the oral delivery of therapeutic peptides as treatments for various diseases. In 1998 he was awarded a Raine grant to continue with research studies in the Lipoprotein and Macromolecular research group relating to the development of the breath test for dietary fat metabolism in man which has led to many publications. Research at the Centre of Excellence for Alzheimer's Disease Research and Care (Edith Cowan University) and Psychiatry and Clinical Neurosciences (UWA) have led to a patent related to the interactions between apolipoprotein E and β-amyloid and its clearance by the liver and its role in Alzheimer’s Disease. The interaction of apo E and β amyloid proteins are of considerable importance and have led to the association between coronary heart disease and Alzheimer’s disease. Obese and diabetic individuals are at extreme risk for the development of atherosclerosis and studies indicate that these individuals are also at risk for the development of Alzheimer’s Disease. High fat/high cholesterol diets and oxidative stress in Western countries are risk factors for age related diseases and AD with other environmental factors such as exercise and cholesterol lowering drugs involved in regulating cholesterol metabolism as potential therapies for AD. Diet and fat intake are important when considering the risk for Alzheimer’s disease and diet induced hypercholesterolemia was used as a model to assess the relationship between steatosis (hepatic dysfunction) and brain oxidative damage associated with neurodegeneration (Centre of Excellence for Alzheimer’s Disease Research and Care at ECU). Drugs that lower cholesterol levels by preventing oxidative stress and hepatic steatosis are currently being considered and tested as potential therapies for the treatment of AD in collaboration with the international drug company Pfizer Ltd. Drugs such as Avasimibe that have been tested in vivo and improve the expression of specific Anti aging proteins and act as activators that improve the transport of vitamin E to the brain add to the growing body of evidence indicating that the lipid soluble vitamin E in the brain is responsible for maintainence of brain cholesterol homeostasis. These cholesterol lowering drugs may treat AD by the reversal of brain aging in various Western populations. Novel screening methods have been recently developed to identify peptides that selectively bind A and form the basis of a new class of drugs to treat AD. PUBLICATIONS 2018-2012 INVITED: EDITORIALS, ARTICLES, REVEIWS and EBOOKS INTERNATIONAL CO-OPERATION 1. Martins IJ. Advances in Aging and Health Research. Scientific Research Publishing, Inc. ISBN: 978-1-61896-569-1 2. Martins IJ. Scientific Nutritional Health and Global Chronic Disease. Scientific Media. New Distribution Report. 2018;443:1-3 Martins IJ. Scientific Nutritional Health and Global Chronic Disease. Scientific Media. New Distribution Report. 2018;443:1-3 3. Martins IJ (2018) S Brain Stimulation Therapies in Neuropsychiatric and Neurodegenerative Diseases. Int J Genom Data Min: IJGD-127. Vol 2018, 02. 4. Martins IJ. Chapter 01. Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. Top 10 Contribution on Genetics. Book Chapter. 2018. www.avid.science.com 5. Martins IJ. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3. 6. Martins IJ. Heat shock protein aggregation and chronic kidney disease. Research on Chronic Diseases. 2018;2(1): 42-44. 7. Martins IJ. Diet, Drug and Inhibitor Therapy Prevent Toxic Protein Aggregation in Various Species. Acta Scientific Nutritional Health. 2(8);2018:01-03. 8. Martins IJ. Genomic Medicine and Endocrine Autoimmunity as Key to Mitochondrial Disease. Glob J Endocrinol Metab .2(2). GJEM.000534.2018. 9. Martins IJ. Anti-Aging Gene linked to Appetite Regulation Determines Longevity in Humans and Animals. International Journal of Aging Research. 2018,1(6): 1-4. 10. Martins IJ. Heat Shock Gene Inactivation and Protein Aggregation with Links to Chronic Diseases. Diseases. 2018, 6;39:1-5. 11. Martins IJ. Electroconvulsive Therapy and Heat Shock Gene Inactivation in Neurodegenerative Diseases. Ann Neurodegener Dis. 2018, 3(1): 1028. 12. Martins IJ. Appetite Control and Biotherapy in the Management of Autoimmune Induced Global Chronic Diseases. J Clin Immunol Res. 2018; 2(1): 1-4. 13. Martins, I.J. (2018) Indian Spices and Biotherapeutics in Health and Chronic Disease. Health, 10, 374-380. 14. Martins IJ. Genomic Medicine and Acute Cardiovascular Disease Progression in Diabetes. International Journal of Medical Studies. 2018;3(1): 124-130. 15. Martins IJ. Biotherapy and the Immune System in Ageing Science. Acta Scientific Nutritional Health 2.4 (2018): 29-31. 16. Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment, InTech - open science | open minds ISBN 978-953-51-3924-9. 17. Martins IJ. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215. 18. Martins IJ. Advances in Biomarkers and Insulin Therapy with Relevance to Reversal of Diabetes. Journal of Studies on Diabetes 2018; 1(1): 9-14. 19. Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, Gupta S, O'Bryant S, Rembach A, Ames D, Ellis K, Fuller SJ, Brown B, Gardener SL, Fernando B, Bharadwaj P, Burnham S, Laws SM, Barron AM, Goozee K, Wahjoepramono EJ, Asih PR, Doecke JD, Salvado O, Bush AI, Rowe CC, Gandy SE, Masters CL. Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. J Alzheimers Dis. 2018;62(3):965-992 20. Martins IJ. Indian Spices and Insulin Therapy in Diabetes and Neurodegenerative Diseases.J Diab Clin Stud. 2018; Volume 1(1). 21. Martins IJ. Regulation of Body Temperature and NAFLD in Global Population. Feb 2018. Asian Hospital and Healthcare Management e-Newsletter. https://www.asianhhm.com/.../regulation-of-body-temperature-and-nafld-in-global-po... 22. Martins IJ. Evaluation of diagnostic tests in human health and disease. J Clin Path Lab Med. 2018;2(1):13-15. 23. Martins IJ. Indian spices and Caffeine treatment for Obesity and Cardiovascular disease. Ann Clin Endocrinol Metabol. 2018; 2: 010-014 24. Martins IJ. Food Quality and Advances in Pharmacological Management Prevent Mitochondrial Apoptosis and Epilepsy Induced Stroke. Research and Reveiws: Neuroscience. 2018;2:7-9. 25. Martins IJ. Genomic medicine and acute cardiovascular disease progression in diabetes. Res Chron Dis (2018) 2(1), 001–003. 26. Martins IJ. Indian Spices and Unhealthy Diets interfere with Drug Therapy in Diabetes and Neurodegenerative Diseases. NAPDD 002 2018; 3(4):555616. 27. Martins IJ. Antimicrobial Drugs and Bacterial Amyloid Peptide Induce Toxic Manifestations in Chronic Diseases. EC Pharmacology and Toxicology 6.1 (2018): 01-04. 28. Martins IJ. Appetite Control and Nutrigenomic Diets are Connected to Immune Regulation and Diabetes Prevention. EC Nutrition 12.3 (2017): 120-123. 29. Martins IJ. The Future of Biomarkers Tests and Genomic Medicine in Global Organ Disease. Microbiology and Infectious Diseases. 2017; 1(1): 1-6. 30. Martins IJ. Antibiotic Resistance Involves Antimicrobial Inactivation in Global Communities. SAJ Pharma Pharmacol 2017;2: 102. 31. Martins IJ. Insulin Therapy Inactivation is connected to NAFLD and Diabetes Severity Index. J Diab Clin Stud. 2017; 1: 001-003. 32. Martins IJ. The Limitations of Food Intake and Biomarkers in the Prevention of Chronic Diseases. Nov Tech Nutri Food Sci. 1(1).NTNF.000502. 2017. 33. Martins IJ. Caffeine with Links to NAFLD and Accelerated Brain Aging. Chapter: Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment. InTech - Open Science Open Minds | InTechOpen. 2017. 34. Martins IJ. Functional Foods and Active molecules with relevance to Health and Chronic disease: Editorial. Functional Foods in Health and Disease 2017; 7(10): 833-836. 35. Martins IJ. Apelin and Sirtuin 1 dysregulation induce Endocrine and Metabolic Disorders in Chronic disease. 1 (1) GJEM 000501. 2017. 36. Martins IJ. Genomic Medicine and Management of Genetic Disorders. J Genet Disord. 2017; Vol. 1 No.1: 06. 37. Martins IJ. Biomarker Tests and Ageing Science. Ageing Sci Ment Health Stud. 2017; 1(1): 1–2. 38. Martins IJ. Autoimmune disease and mitochondrial dysfunction in chronic diseases. Res Chron Dis (2017) 1(1). 39. Martins IJ. Antimicrobial activity inactivation and toxic immune reactions induce Epilepsy in human. J Med Discov (2017);2(4):jmd17040. 40. Martins IJ (2017) Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. Vol. 3 No. 3:24. 41. Martins IJ. Regulation of Core Body Temperature and the Immune System Determines Species Longevity. Curr Updates Gerontol. (2017) 1: 6.1 42. Martins IJ. Heat Therapy With Relevance to the Reversal of NAFLD and Diabetes. J Diabetes Metab Disord. 2017; 4: 018. 43. Martins IJ. Inactivation of Anti-Aging Genes is Related to Defective Drug Metabolism in Diabetes. Int J Drug Disc. 2017; 1:003. 44. Martins IJ. Dietary Interventions Reverse Insulin and Synaptic Plasticity Defects Linking to Diabetes and Neurodegenerative Diseases. SL Nutrition and Metabolism. 2017; 1:111:1-5. 45. Martins IJ. Magnesium deficiency and induction of NAFLD and Type 3 diabetes in Australasia. AMJ 2017;10(3):235-237. 46. Martins IJ. Avasimibe and Sirt 1 Activators Reverse NAFLD and Obesity. Nov Appro Drug Des Dev. 2017; 1(3) : 555561. 47. Martins IJ. Defective Inter¬play between Adipose Tissue and Immune System Induces Non Alcoholic Fatty Liver Disease. Updates Nutr Disorders Ther. 2017; 1: 3.1 48. Martins IJ. Bacterial LPS Overrides Adenosine Treatment of Epileptic Seizures. EC Microbiology 7.3 (2017): 83-86. 49. Martins IJ. Sirtuin 1 and Adenosine in Brain Disorder Therapy. J Clin Epigenet. 2017, 3:1. 50. Martins IJ. Caffeine Consumption and Induction of Obesity in the Developed World. Ann Obes Disord. 2017; 2(1): 1018. 51. Martins IJ. Nutrigenomic Diets and Caffeine Determines the Intelligence Quotient and Thinking in Developing Countries. Research and Reveiws: Neuroscience. 2017.1:2. 52. Martins IJ. Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019. 53. Martins IJ. Dietary Interventions Reverse Insulin and Synaptic Plasticity Defects Linking to Diabetes and Neurodegenerative Diseases. Updates Nutr Disorders Ther. 2017; 1: 4.1. 54. Martins IJ. Apelinergic System Defects with Relevance to Mental Disorders in Diabetes. World J Psychiatry Ment Health Res. 2017; 1(1): 1001. 55. Martins IJ. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol . 2017. 2(1): 00013. 56. Martins IJ. Calorie Sensitive Anti-Aging Gene Regulates Hepatic Amyloid Beta Clearance in Diabetes and Neurodegenerative Diseases”. EC Nutrition ECO.01 (2017): 30-32. 57. Martins IJ. Heat Shock Gene Dysregulation and Inactivation of Drug Therapy. EC Pharmacology and Toxicology. ECO.01 (2017): 13-15. 58. Martins IJ. Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases. EC Pharmacology and Toxicology 3.1 (2017): 18-21. 59. Martins IJ. Food and Nutrition cause liver and brain diseases ... - Atlas of Science: Another Veiw on Sciencehttps://atlasofscience.org/food-and-nutrition-cause-liver-and-brain-diseases-with-diabe... Mar 11, 2016 - 60. Martins IJ. Early diagnosis of neuron mitochondrial dysfunction may reverse global metabolic and neurodegenerative disease. Global Journal of Medical Research.. 2016;2: 1-8. CERTIFICATE OF PUBLICATION 61. Martins IJ. FOOD INTAKE AND CAFFEINE DETERMINE AMYLOID BETA METABOLISM WITH RELEVANCE TO MITOPHAGY IN BRAIN AGING AND CHRONIC DISEASE. European Journal of Food Science and Technology. 2016;4:11-17. 62. Martins IJ. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016; 8: 322-324. 63. Martins IJ. Geriatric Medicine and Heat Shock Gene Therapy in Global Populations. Curr Updates Gerontol. 2016;1: 1-5. 64. Martins IJ. Heat shock gene Sirtuin 1 regulates post-prandial lipid metabolism with relevance to nutrition and appetite regulation in diabetes. International Journal of Diabetes and Clinical Diagnosis. Int J Diab Clin Diagn. 2016, 3:20. 65. Martins IJ. Caffeine consumption with Relevance to Type 3 diabetes and accelerated brain aging. Research and Reveiws: Neuroscience. 1,1, December, 2016. 66. Martins IJ. Food quality induces a miscible disease with relevance to Alzheimer’s disease and Neurological diseases, J Food Research, vol. 5, pp.45-52, 2016 67. Martins IJ. Appetite Control with Relevance to Mitochondrial Biogenesis and Activation of Post- Prandial Lipid Metabolism in Obesity Linked Diabetes. Ann Obes Disord. 2016; 1(3): 1012. 68. Martins IJ. Type 3 diabetes with links to NAFLD and Other Chronic Diseases in the Western World. International Journal of Diabetes. 2016; 1:1-5. 69. Martins IJ. Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease. Health, 2016, 8, 694-710. 70. Martins IJ. Diet and Nutrition reverse Type 3 Diabetes and Accelerated Aging linked to Global chronic diseases. J Diab Res Ther. 2016; 2(2). 71. Martins, I.J. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26 72. Martins, IJ.The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 4(2) 1-19. 73. Martins IJ. Drug Therapy for Obesity with Anti-Aging Genes Modification. Ann Obes Disord. 2016; 1(1): 1001. 74. Martins, IJM. (2015) Overnutrition Determines LPS Regulation of Mycotoxin Induced Neurotoxicity in Neurodegenerative Diseases. Int J Mol Sci.16(12): 29554–29573. 75. Bates KA, Sohrabi HR, Rainey-Smith SR, Weinborn M, Bucks RS, Rodrigues M, Beilby J, Howard M, Taddei K, Martins G, Paton A, Shah T, Dhaliwal SS, Foster JK, Martins IJ, Lautenschlager NT, Mastaglia FL, Gandy SE, Martins RN. Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. Int J Neurosci. 2016 May 15:1-10. [Epub ahead of print] 76. Martins IJ. Nutritional and Genotoxic Stress Contributes to Diabetes and Neurodegenerative Diseases such as Parkinson's and Alzheimer's Diseases. - Frontiers in Clinical Drug Research -CNS and Neurological Disorders. Volume 3 Editor: Atta-ur-Rahman Pp. 158-192 (35) 2015 77. Martins IJ. Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer’s disease. Photon ebooks. 2015. UBN: 015-A94510112017Edition: I Impact Index: 4.1. Dr Ian Martins is conferred with the RICHARD KUHN RESEARCH AWARD-2015 ENDOCRINOLOGY AND METABOLISM. 78. Martins IJ. Nutrition increases Survival and Reverses NAFLD and Alzheimer's disease Ian J Martins •First Edition edited by Alina Berdos, 01/2015; LAP LAMBERT., ISBN: 978-3-659-78371-5. Printed/Ebook Release 79. Martins IJ. Unhealthy Diets Determine Benign or Toxic Amyloid Beta States and Promote Brain Amyloid Beta Aggregation. Austin J Clin Neurol 2015;2(7): 1060-66. 80. Martins IJ. Diabetes and Cholesterol Dyshomeostasis Involve Abnormal α-Synuclein and Amyloid Beta Transport in Neurodegenerative Diseases. Austin Alzheimers J Parkinsons Dis. 2015;2(1): 1020-28. 81. Fernando WM, Martins IJ, Goozee KG, Brennan CS, Jayasena V, Martins RN. The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action The British journal of nutrition 05/2015; Epub ahead of print:1-14. 82. Xu H, Gupta VB, Martins IJ, Martins RN, Fowler CJ, Bush AI, Finkelstein DI, Adlard PA. Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way. Neurobiol Dis. 2015 Sep;81:38-48. doi: 10.1016/j.nbd.2015.06.016. Epub 2015 Jun 25. 83. Martins IJ. Diabetes and Organ Dysfunction in the Developing and Developed. World Global Journal of Medical Research: F Diseases Volume 15 Issue 1 Version 1.0 Year 2015. CERTIFICATE OF PUBLICATION 84. Martins IJ. Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global communities. Journal of molecular and genetic medicine: an international journal of biomedical research 03/2015; 9(1). 85. Martins IJ. LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research 03/2015; 4(2):69-77. 86. Martins IJ (2014) The Global Obesity Epidemic is Related to Stroke, Dementia and Alzheimer’s disease. JSM Alzheimer’s Dis Related Demen¬tia 1(2): 1010. 87. Martins, IJ. (2014) Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries. Open Journal of Endocrine and Metabolic Diseases, 4, 90-110 88. I.J. Martins and W. Fernando (2014) High Fibre Diets and Alzheimer’s Disease. Food and Nutrition Sciences (Diet and Disease), Vol. 5 No. 4, 410-424. 89. Martins IJ and Creegan R (2014) Links between Insulin Resistance, Lipoprotein Metabolism and Amyloidosis in Alzheimer’s Disease. Health Vol.6 No.12. 90. Martins IJ, Gupta V, Wilson AC, Fuller SJ and Martins RN (2014) Interactions Between Apo E and Amyloid Beta and their Relationship to Nutriproteomics and Neurodegeneration. Current Proteomics, 11, 173-183. 91. W. L.Florence Lim, I.J. Martins, R.N.Martins. (2014). The involvement of lipids in Alzheimer's disease. J Genet Genomics 41(5):261-74. 92. Martins IJ. Appetite dysregulation and obesity in Western Countries Ian J Martins • First edited by Emma Jones,; LAP LAMBERT Academic Publishing., ISBN: 978-3-659-40372-9. Printed/Ebook Release. 93. Martins IJ, Creegan R, Lim WLF and Martins RN. (2013). Molecular insights into appetite control and neuroendocrine disease as risk factors for chronic diseases in Western countries. Special Issue. Molecular Mechanisms Involved in Inflammation and Insulin Resistance in Chronic Diseases and Possible Interventions. Open Journal of Endocrine and Metabolic Diseases. 3;11-33. 94. Martins IJ (2013) Increased Risk for Obesity and Diabetes with Neurodegeneration in Developing Countries. J Molecular Genetic Medicine S1: 001 95. Martins IJ , Wei Ling Lim, Wilson A, Laws S and Martins RN. (2013) The acceleration of aging and Alzheimer’s disease through the biological mechanisms behind obesity and type II diabetes. Health.5; No 5:913-920. 96. Martins IJ, Wilson AC, Lim WLF, Laws SM, Laws SM, Fuller SJ and Martins RN (2012) Sirtuin 1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes. Special Issue on Obesity. Health. 4: 1448-1456. Publications 2012- 1989 Publications 2009-1989 Publications 2009-1989 Publications 2009-1989 1. Lau S, Bates KA, Sohrabi HR, Rodrigues M, Martins G, Dhaliwal SS, Taddei K, Laws SM, Martins IJ, Mastaglia FL, Foster JK, Phillips JK, Martins RN. Functional effects of genetic polymorphism in inflammatory genes in subjective memory complainers. Neurobiol Aging. 2012 Jun;33(6):1054-6. Epub 2010 Oct 18 2. Sharman MJ, Shui G, Fernandis AZ, Lim WL, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum JD, Gandy S, Wenk MR and Martins RN. Profiling brain and plasma lipids in human APO E epsilon2, epsiolon3 and epsilon4 knockin mice using electronspray ionization mass spectrometry. Journal of Alzheimer’s disease. 20(1);105-111.2010. (Imapact factor 5.0) 3. Martins IJ, Berger T, Sharman MJ, Verdile G, Fuller SJ and Martins RN. Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease. Journal of Neurochemistry. 111:1275-308. 2009.).(Impact Factor = 4.5) 4. Bates KA, Sohrabi H, Rodrigues M, Beilby J, Dhaliwal S, Taddei K, Criddle, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster J, Martins IJ, Lautenschlager N, Mastaglia F, Laws SM and Martins RN. Association of cardiovascular factors and Alzheimer’s disease plasma amyloid beta protein in subjective memory complainers.Journal of Alzheimer’s Disease. 17(2):305-18.2009.(Impact Factor = 5.0) 5. Taddei K, Laws SM, Verdile G, Munns S, D’Costa K, Harvey AR, Martins IJ, Hill F, Levy E, Shaw JE and Martins RN. Novel phage peptides attenuate beta amyloid -42 catlalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging. 2009 (E-PUB ahead of print). (Impact Factor = 6.1) 6. Sharman MJ, Guanghou Shui, Aaron Z. Fernandis, Wei Ling F. Lim, Tamar Berger, Eugene Hone, Kevin Taddei, Ian J. Martins, Jorge Ghiso, Joseph Buxbaum, Sam Gandy, Markus R. Wenk and Ralph N. Martins. APOE genotype results in only subtle changes in brain lipids in human APOE 2, 3 and 4 knock-in mice. Journal of Alzheimer’s Disease. 20 (2);403-9.. 2010. (Impact Factor = 5.0) 7. Martins IJ, Hone E, Foster JK, Sunram-Lea SI, Gnjec A, Fuller SJ, Nolan D, Gandy SE, Martins RN. Apolipoprotein E, cholesterol metabolism, diabetes and the convergence of risk factors for Alzheimer’s disease and cardiovascular disease. Molecular Psychiatry. 11: 721-36; 2006. Review (Impact Factor = 12.5) 8. Hone E, Martins IJ, Jeoung M, Ji TH, Gandy SE and Martins RN. (2005). Alzheimer’s disease Aβ peptide modulates apo E isoform specific effects on receptor binding. Journal of Alzheimer’s Disease. 7 :303-14; 2005. (Impact Factor =5 .0) 9. Martins IJ, Redgrave TG (2004) Obesity and post-prandial lipid metabolism. Feast or Famine? J Nutr Biochem. 15:130-41 Review. (Impact Factor = 4.35) 10. Hunter M, Bernard R, Freitas E, Boyer A, Morar B, Martins IJ, Tournev I, Jordanova A, Guergelcheva V, Ishpekova B, Kremensky I, Nicholson G, Schlotter B, Lochmuller H, Voit T, Colomer J, Thomas PK, Levy N, Kalaydjieva L, (2003) Mutation screening of the N-myc downstream-regulated gene 1 (NDRG1) in patients with Charcot-Marie-Tooth Disease. Human Mutation 22:129-35. (Impact Factor = 7.0) 11. Dane-Stewart CA, Watts GF, Barrett PH, Stuckey BG, Mamo JC, Martins IJ, Redgrave TG (2003) Chylomicron remnant metabolism studied with a new breath test in postmenopausal women with and without type 2 diabetes mellitus. Clinical Endocrinology 58:15-20. (Impact Factor = 3.8) 12. Hone E, Martins, IJ, Fonte J, Martins RN (2002) Apolipoprotein E influences amyloid-beta clearance from the murine periphery. Journal of Alzheimer’s Disease. 5:1-8. (Impact Factor = 5.0) 13. Dane-Stewart CA, Watts GF, Mamo JC, Barrett PH, Martins IJ, Dimmitt SB, Redgrave TG (2002) Effect of Simvastatin on markers of triglyceride-rich lipoproteins in familial hypercholesterolemia. European Journal of Clinical Investigation. 32:493-499 (Impact Factor = 3.0) 14. Martins IJ, Tran JML Redgrave TG (2002) Food restriction normalizes chylomicron remnant metabolism in murine models of obesity as assessed by a novel stable isotope breath test. Journal of Nutrition 132:176-181 (Impact Factor = 3.7) 15. Chan DC, Watts GF, Barrett PHR, Martins IJ, James AP, Mamo JCL, Mori TA, Redgrave TG (2002) Effect of atorvastatin on chylomicron remnant metabolism in visceral obesity: a study employing a new stable isotope breath test . J. Lipid Res. 43:706-712 (Impact Factor = 4.4) 16. Watts GF, Barrett PHR, Marais AD, Dane-Stewart CA, Martins IJ, Dimmitt SB, Redgrave TG (2001) Chylomicron remnant metabolism in familial hypercholesterolemia studied with a stable isotope breath test. Atherosclerosis 157:519-523 (Impact Factor = 4.6) 17. Watts GF, Chan DC, Barrett PH, Martins IJ, Redgrave TG (2001) Preliminary experience with a new stable isotope breath test for chylomicron remnant metabolism: a study in central obesity. Clinical Science. 101:683-90 (Impact Factor = 4.2) 18. Redgrave TG, Watts GF, Martins IJ, Barrett PHR, Mamo JCL, Dimmitt SB, Marais AD (2001) Chylomicron remnant metabolism infamilial dyslipidemias studied with a remnant-like emulsion breath test. J. Lipid. Res. 42:710-5 (Impact Factor = 4.4) 19. Martins IJ, Hone E, Chi C, Seydel U, Martins RN, Redgrave TG (2000) Relative roles of LDLr and LRP in the metabolism of chylomicron remnants in genetically manipulated mice. J. Lipid. Res. 41:205-213. (Impact Factor = 4.4) 20. Martins IJ, Vermuellen R, Redgrave TG (2000) Relative roles of mitochondrial and peroxisomal fatty acid oxidation in the metabolism of chylomicron remnants in rats and mice as assessed by a stable-isotope breath test. Atherosclerosis.150:13-20. (Impact Factor =4.6) 21. Phan CT, Mortimer B-C, Martins IJ, Redgrave TG, (1999) Dietary fats, influences on the clearance of chylomicrons in the rat. Am .J. Clin. Nutr. 69:1151-61. (Impact Factor = 7.7) 22. I.J. Martins and T. G. Redgrave. 1998. A 13CO2 breath test for the assessment of remnant metabolism in mice. J Lipid. Res. 39: 693-699. (Impact Factor = 4.4) 23. I.J. Martins, C. Vilchèze, B-C. Mortimer, R. Bittman, and T. G. Redgrave. 1998. Sterol side chain length and structure affect the clearance of chylomicron-like emulsions in rats and mice. J. Lipid Res. 39: 302-312. (Impact Factor =4.4) 24. B.J. Zeng, B-C. Mortimer, I.J. Martins, U. Seydel and T.G. Redgrave. 1998. Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes. J.Lipid. Res.39: 887-905. (Impact Factor = 4.4) 25. B-C. Mortimer, I.J. Martins, B.J. Zeng and T.G. Redgrave. 1997. Use of gene-manipulated models to study the physiology of lipid transport. J. Clin. Exp. Pharm. Phsyiol. 24: 281-285. (Impact Factor = 2.2) 26. I.J. Martins, B-C. Mortimer and T. G. Redgrave. 1997. Effect of the ACAT inhibitor CL 277,082 on apolipoprotein B48 transport in mesenteric lymph and on the plasma clearance of chylomicrons and remnants. Arteriosclerosis. Thrombosis and Vascular Biology. 17: 211-216. (Impact Factor = 7.6 ) 27. I.J. Martins, B-C. Mortimer, J. Miller and T. G. Redgrave. 1996. Effects of particle size and number on the plasma clearance of chylomicrons and remnants. J. Lipid. Res. 1996. 37: 2696-2705. (Impact Factor = 4.4) 28. T.G. Redgrave, B. C. Mortimer, I.J. Martins. Receptor-ligand interactions in the hepatic uptake of chylomicron remnants studied with genetically manipulated mice. In: Hepatic endocytosis of lipids and proteins. 34 Suppl 1996.3. 105-107. Zietschrift fur Gastroenterologie. (Impact Factor =0.88) 29. Redgrave, T.G., IJ. Martins, and B-C. Mortimer. 1995. Measurement of expired carbon dioxide to assess the metabolism of remnant lipoproteins. J. Lipid Res. 36: 2670-2675. (Impact Factor = 4.4) 30. Mortimer, B-C., D.J. Beveridge, I.J. Martins and T.G. Redgrave. 1995. Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apo E-deficient mice. Evidence for slow metabolism via an alternative apo E dependent pathway. J. Biol. Chem. 48: 28767-28776. (Impact Factor = 5.5) 31. I.J.Martins, A.J. Sainsbury, J.C.L. Mamo and T.G. Redgrave. 1994. Lipid and apolipoprotein B48 transport in mesenteric lymph and the effect of hyperphagia on chylomicron clearance in insulin-deficient rats. Diabetologia. 37: 238-246. (Impact Factor = 6.42) 32. I.J. Martins and T. G. Redgrave. Measurement of chylomicron remnant metabolism by a newly developed breath test for the evaluation of post-prandial atherogenesis. The Ist International workshop on Atherosclerosis Research of Australian-Japanese co-operation. Tokyo Jan 20-21. 1994. 74-77. Editors: Akira Yamamoto and P.J. Nestel. 33. B.C. Mortimer, D.J.Holthouse, I.J.Martins, R.V. Stick and T.G. Redgrave. 1994. Effects of triacylglycerol saturated acyl chains on the clearance of chylomicron-like emulsions from the plasma of the rat. Biochim. Biophys. Acta. 1211: 171-180. (Impact Factor = 4.2 ) 34. Y. Chen, M. A. Burton, I.J. Martins, J.P.Coode, S.Napoli and B. N. Gray. 1992. Evaluation of Ion-exchange microspheres as carriers for the anti-cancer drug Doxorubicin: In vitro studies. J. Pharm. Pharmacol. 44: 211-215. (Impact Factor = 1.85) 35. S.Napoli, I.J. Martins, M. A. Burton,Y. Chen, J.P.Coode, S.Napoli and B. N. Gray. 1992.Dose response and toxicity of doxorubicin microspheres in a rat tumour model.Anti-cancer Drugs.3 (1): 47-53. (Impact Factor =2.36) 36. I.J.Martins and T.G. Redgrave. 1992. The effects of Insulin-deficiency on the metabolism of High Density Lipoprotein Phospholipids in Rats. Biochem J. 281: 851-857. (Impact Factor = 4.4) 37. I.J.Martins, L. Hopkins, C. Joll and T.G. Redgrave. 1991. Interactions between triacylglycerol-rich Model lipoproteins and High Density lipoproteins in rat, rabbit and man. Biochim. Biophys.Acta. 1081: 328-338. (Impact Factor = 4.18) 38. N.P. Lenzo, I.J. Martins, B. C. Mortimer and T.G. Redgrave. 1988. Effects of phospholipid composition on the metabolism of triacylglycerol, cholesteryl ester and phosphatidylcholine from lipid emulsions injected intravenously in rats. Biochim. Biophys. Acta. 960: 111-18. (Impact Factor = 4.18) 39. I.J. Martins, N.P. Lenzo and T.G. Redgrave. 1989. Phosphatidylcholinemetabolism after transfer from lipid emulsions injected intravenously into rats. Implications for High Density lipoprotein metabolism. Biochim. Biophys. Acta. 1005: 217-224. (Impact Factor = 4.18 ) Previous Research & Research Interests Chylomicron remnants (CR) are known to contribute to the development of atherosclerosis. In situations of extreme defects in CR metabolism it is clear that CR have the potential to contribute to the development of atherosclerosis. The capacity to metabolize cholesterol-rich remnant lipoprotein particles contributes to the risk of atherosclerosis in man, as measured by the progression of coronary atherosclerosis determined angiographically. It is commonly assumed that in Western societies the high risk of atherosclerosis is mainly due to the presence in plasma of these atherogenic lipoproteins since most individuals are in the postprandial state for most of the day. Currently, there are limitations in the existing methods for assessing CR metabolism, which has hindered the understanding of the contribution of cholesterol-rich remnants to the development of coronary artery disease. The emulsion technique for tracing CR clearance has been validated in man. In recent studies a breath test has been developed that has been shown to monitor CR clearance and metabolism. After clearance from plasma the lipid emulsions are removed by receptor-mediated endocytosis, the cholesteryl esters are subsequently degraded in lysosomes where the lipid components are hydrolyzed and fatty acids become available for oxidative metabolism, in particular metabolism to carbon dioxide. In experimental animals the clearance and metabolism of emulsion remnants was monitored by the appearance in breath of labeled 14CO2 after injection of lipid emulsions labeled with cholesteryl [1-14C]oleate. A 13C breath test for CR metabolism has been developed. This procedure is extremely advantageous since the emulsion contains cholesteryl [1-13C]oleate and avoids the use of radioactive cholesteryl [1-14C]oleate. To determine the specificity and sensitivity of the 13C breath test in detecting changes in CR metabolism, experiments have been performed with different 13C labelled cholesteryl esters, with various transgenic mice, and the effects of feeding and of diurnal variation have been established. Measurements by the breath test provide an integrated assessment of capacity for clearance and subsequent metabolism of the CR of the triglyceride-rich lipoproteins. In man breath tests for CR metabolism have been conducted in obese individuals. The results show that CR as assessed by the breath test was markedly decreased in obese individuals when compared with lean individuals. Patents Title of Invention: Screening Methods and the use of Identified Agents for Alzheimer’s disease. PCT/AU02?01754 2002 (Current) Alzhyme Pty Ltd. Title of Invention: Use of apolipoprotein or clearing beta amyloid protein from the periphery PS3056 2002 (Not continuing) Alzhyme Pty Ltd. Title of Invention: Diagnostic AT Breath test International Patent application No. PCT/AU94/00663 Title of Invention: Labelled diagnostic compositions and method of their use United States Patent application No. 08/648080 Title of Invention: Oral Delivery of Peptides International Patent application No. PCT/AU97/00344 Consultancies Consultant to Inovax Ltd. (Scientific Advisor) Inovax (Australia) 1994-1999 Other Academic Contributions Reviewer for various International Journals (few examples) International Journal of Diabetes Research Medical Science Monitor Arteriosclerosis Thrombosis and Vascular disease International Journal of Obesity and related metabolic disorders (Nature Publishing group) Free Radical Biology and Medicine (Elsevier Science Inc.) Journal of Nutrition Reviewer for National Heath and Medical Research Council Assessor for NHMRC 1999/2000 Research Grants Awarded Chief/Associate Investigators: NHMRC 595312 & NHMRC 595300 Prof. R.Martins, Dr I. Martins, D K.Taddei, Dr M. Ladu, Dr M. Sharman 2010-2012 $938,775 The effect of human apo E isoforms and apo E receptors on the clearance of oligomeric abeta42 by hepatocytes in vitro Enhancing peripheral clearance of beta amyloid as a treatment for AD Prof. R.Martins ,Dr I. Martins, Dr G Verdile , Dr J.Phillips. 2007-2009 Continuing. Alzheimer’s Disease and Research Care $327,890 Investigating beta amyloid clearance in vivo Chief Investigator: NHMRC 324100 Prof. R.Martins, Dr I. Martins, A/Prof Nicola Lautenschlager 2005-2007 $422,750 Molecular and Neuropsychological Predictive Markers of Cognitive Decline ECU Small Grant Chief Investigator: Dr I. Martins 2006 Current Status: Completed $5000 Cholesterol, High fat diets, exercise and cholesterol lowering drugs on beta-amyloid Clearance and deposition in brains of Alzheimer’s transgenic mice Hollywood Pvt Hospital Res Grant Dr I. Martins 2006 Current Status: Completed. $10,000 Raine Research Foundation Dr I. Martins 1999-2000 Current Status: Completed $169,000 Metabolism of postprandial lipoproteins in mice and man Innovax Ltd. Co-Chief investigator on Industry Grant: 1994-1998 Current Status: Completed $1,200,000 Development of a breath test for chylomicron remnant metabolism in mice and man Athelstan and Saw grant Chief Investigator Dr I Martins 1994 Current Status: Completed $50,000 Effects of butterfats and oils on the clearance of chylomicron remnants NHMRC Co-investigator: Dr I Martins 1993-1995 Current Status: Completed $150,000 Binding and endocytosis of chylomicron remnants by low density lipoprotein receptors and proteoglycans to liver cells IMPACT OF PREVIOUS RESEARCH TO THE FIELD OF MEDICINE AND LABORATORY TECHNOLOGY THAT MAY AVOID INADVERTENT ERRORS AND MAY TRANSLATE TO COMMERCIALISATION OF MEDICAL RESEARCH THAT DETERMINE CRITICAL HEATLH OUTCOMES. Development of a BLOOD TEST has been of critical interest to the QUALITY CONTROL of plasma/sera samples for metabolic disease with relevance to diabetes and neurodegenerative diseases. RELEVANT PUBLICATIONS: 1. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215. CERTIFICATE OF PUBLICATION. 2. Evaluation of diagnostic tests in human health and disease. J Clin Path Lab Med. 2018;2(1):13-15. SIRTUIN 1 ANALYSIS ON BLOOD/PLASMA SAMPLES SHOULD BE CONDUCTED IN APPROPRIATE PRESERVATIVE, UNDER FREEZE/THAW CONDITIONS, STORAGE CONDITIONS. Bacterial LPS should be conducted (Sirtuin 1 repression) to avoid bacterial contamination with long term storage. ONLINE REFERENCES: 1. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol. 2017. 2. The Future of Biomarkers Tests and Genomic Medicine in Global Organ Disease. Arch Infect Dis Ther. 2017. 3. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016. 4. The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 5. LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research 2015. Dr Martins research with relevance to diet, diabetes and neurodegenerative diseases builds upon his past > 150 publications that generates outputs that will have relevant and significant impact to the global community. The incidence of diabetes and non alcoholic fatty liver disease (NAFLD) has been predicted to increase to 21% by 2050. Novel and critical elements of scholarly peer review provides information that the heat shock gene Sirtuin 1 is repressed with relevance to diabetes, neurological diseases and Alzheimer's disease. Major unsolved challenges to advances in biology may now provide evidence to reverse Sirtuin 1 dysfunction that is connected to primarily to heat shock protein metabolism and secondly to toxic amyloid beta metabolism with mitochondrial apoptosis in liver and brain cells. In the developing world increased levels of bacterial lipopolysaccharides repress the anti-aging gene Sirtuin 1 with the development of diabetes, neurodegenerative diseases and Alzheimer’s disease. Unhealthy diets accelerate Type 3 diabetes with the induction of NAFLD in Global Populations.Food and Nutrition cause liver and brain diseases with diabetes in the ...https://atlasofscience.org/food-and-nutrition-cause-liver-and-brain-diseases-with-diabe... Mar11,2016 Regulation of Body Temperature and NAFLD in Global Population. Feb 2018. Asian Hospital and Healthcare Management e-Newsletter. 62 INTERNATIONAL CERTIFICATES PRESENTED TO DR IAN JAMES MARTINS 1. CERTIFICATE, BEST ARTICLE, “Diet, Drug and Inhibitor Therapy prevent Toxic protein aggregation in various species” AS Nutritional Health, 2018 Volume 2 Issue 8. 2. CERTIFICATE, E-Poster participation, Insulin resistance and Cholesterol dyshomeostasis involve α-Synuclein and Amyloid beta interactions in Neurodegenerative diseases, 4th World Congress on Parkinsons and Huntington Disease, August 29-30, 2018, Zurich, Switzerland, Editors of the Journal of Neurological Disorders, Conference Series.com 3. Certificate of Recognition, Keynote Speaker, Antimicrobial drugs and bacterial amyloid beta peptide induce toxic manifestations to medical biology and pharmacotherapy, Conference Series and the Editors, Journal of Clinical and Experimental Pharmacology, Journal of Analytical and Bioanalytical Techniques and Journal of Clincal Trials, International Conference on Biomedicine and Pharmacology, August 06-07, 2018 4. Certificate of Recognition, Keynote presentation, Transcriptional dysregulation of Sirtuin 1 is relevant to Diabetes and Global Chronic Disease, Conference Series and the Editors of Journal of Diabetes & Metabolism, Journal of Diabetic Complications & Medicine and Journal of Hypertension, Global Experts Meeting on Diabetes, Hypertension, Metabolic Syndrome”held during July 30-31, 2018 in Melbourne, Australia 5. Biomedical and Pharmacology Journal, REVEIWER OF THE MONTH, Outstanding reviewer for his enexplicable contribution in safeguarding the academic integrity of the Journal. July, 2018. 6. Publication Certificate, Diet, Drug and Inhibitor Therapy prevent toxic protein aggregation in various species, Acta Scientific Nutritional Health, July, 2018 7. Certificate of Recognition, Keynote Speaker, “The Limitations of Laboratory Medicine with relevance to Biomarker tests and Global Organ Disease”, 13th International Conference on Laboratory Medicine and Pathology, June 25-26, Berlin, Germany, Conference Series and the Editors of Diagnostic Pathology: Open Access, Journal of Clinical and Experimental Pathology and the Journal of Molecular and Genetic Medicine. 8. Certificate, Editorial Board Membership, Journal of Studies on Diabetes 9. Review Certificate, Acta Scientific Nutritional Health (ASNH), May 2018 10. Certificate of Editorial Board Membership, REFERENCE NUMBER, ESCIPUB/IJOAR/2018-0011, INTERNATIONAL JOURNAL OF AGING RESEARCH 11. Certificate of Reviewing, Awarded October 2017, Journal of Functional Foods, In cooperation with International Society for Nutraceuticals and Functional Foods 12. Certificate of Recognition, Keynote Speaker, Entitled " Appetite control is involved in Immunotherapy with relevance to cardiovascular disease, NAFLD and Diabetes, Pulsus and Editors of Journals of Immune Disorders and Therapy, Journal of Immunodiagnostics and Journal of Immunopatholgy, 7th World Congress on Immunology, Amsterdam, Netherlands, April 19-20, 2018 13. Certificate of Recognition, Chairing Sessions on Vaccinology, Immunopathology, Immunotherapy, Immune Proteomics, Cancer and Tumour Oncology, 7th World Congress on Immunology, Amsterdam, Netherlands, April 19-20, 2018 14. Certificate of Recognition for Workshop Presentation, Keynote Speaker, Entitled "Diagnosis and Management of Immunological Diseases requires Sirtuin 1 as a Diagnostic protein marker, Pulsus and Editors of Journals of Immune Disorders and Therapy, Journal of Immunodiagnostics and Journal of Immunopatholgy, 7th World Congress on Immunology, Amsterdam, Netherlands, April 19-20, 2018, 15. Review Confirmation Certificate, MDPI Journals, 2017-2018. 16. Publication Certificate: “Biotherapy and the Immune System in Ageing Science”. Acta Scientific Nutritional Health 2.4 (2018): 29-31. 17. Certificate: Eminent Editor-in-chief for Journal of Diabetes and Clinical Studies 18. Publication Certific