Webinar on Enzymes invites all the global leaders and researchers to share their research at this exclusive scientific program held during August 11, 2020, which based on the theme “Origins and Evolution in Enzyme Catalysis and Metabolic Networks”.
Scientific Sessions of Enzymes webinar includes Enzyme discovery & Biochemistry, Molecular Enzymology & Enzyme mechanisms, Clinical Enzymology & Enzyme engineering, Enzyme engineering and recombinant enzyme technology, Computational Enzymology, Enzymes in Food Technology, Structural Biochemistry, Synthetic Biology & Tissue Engineering, Enzymology in Drug Discovery, Enzyme Immobilization & Therapeutics, Enzymology & Proteomics.
Session 1: Enzyme discovery & Biochemistry
Enzymes are both macromolecular and micro molecular proteins and are located evidently. They are macromolecular biological catalysts and boost up chemical reactions. Enzymology deals with the study of enzymes, their kinetics, structure, and function, in addition to their relation to each different. Enzymes play a totally crucial function in the world. They act as a catalyst for a chemical response, whether that reaction includes the execution of DNA for the cause of cellular repair or for the digestion of any forms of meat as well as fowl. Biochemistry is the department of technology which offers with the chemical strategies within and associated with residing organisms. It is a laboratory based totally science that mixes each biology and chemistry. Biochemistry mainly focuses on methods that occur at a molecular level like interior our cells, reading components like proteins, lipids and organelles. It also looks at how cells speak with each other. Biochemists need to apprehend how the molecular structure relates to its function, and then allow them to be expecting that how the molecules will have interaction. Biochemistry covers number medical disciplines, which incorporates genetics, microbiology, forensics, plant technology and medication.
Session 2: Molecular Enzymology & Enzyme mechanisms
Molecular enzymology is that department of biochemistry which encircles or offers with the functional in addition to the structural characteristics of the enzymes within a molecular degree. Enzymes are globular proteins which play a completely essential role as a catalyst for any type of biochemical reactions. Molecular enzymology is based on designing and enzyme synthesis and excessive unmet medical wishes are based on innovative drug objectives. These works are based totally on revolutionary drug targets. Molecular Enzymology's hobby consist of in all factors related to enzymes like discovery of enzymes, structure of enzymes, enzyme mechanisms, cellular and metabolic capabilities of enzymes, discovery of medication, biochemical aspects of enzymes, bioinformatics, computational analysis, research for molecular modelling, newer strategies in enzyme expression in addition to purification, bio catalysis, bio molecular engineering, enzyme kinetics and enzyme inhibitors.
Session 3: Clinical Enzymology & Enzyme engineering
Clinical enzymology deals with the measurement of enzyme activity for the analysis and remedy of sicknesses. Enzymes are macromolecular catalysts which growth the price or pace of physiologic reactions. Each and every reaction happening every day in our frame takes vicinity with the assist of an enzyme or the opposite. In widespread, most of the enzymes are found in cells at plenty better concentrations than that in plasma. Measurement of these tiers in plasma shows whether or not their tissue of starting place is broken causing to the discharge of intracellular additives into the blood. This forms the premise of what's known as medical enzymology. Thus we will say that clinical enzymology refers to size of enzyme hobby for the analysis in addition to the remedy of diseases.
Enzyme engineering or protein engineering is the process of designing proteins or enzymes by changing the sequence of amino acids through recombinant DNA mutation. Directed revolution and rational design are the two techniques used in enzyme engineering or protein designing in the process of drug discovery.Enzymes are large biological molecules responsible for the thousands of metabolic processes that sustain life. They can speed up the reaction and cut back the activation energy required to start the reaction. Without them, most of the reactions would not occur with a suitable efficiency. Most enzymes are proteins, although some catalytic RNA molecules have been identified. Enzyme activity can be affected by other molecules as well. Inhibitors are molecules that decrease enzyme activity, while activators have the opposite function. Temperature, pressure, chemical environment and the concentration of substance can also affect the enzyme’s activity.
Session 5: Computational Enzymology
Computational enzymology is the scientific sub discipline that applies computational molecular simulation and modelling to enzymes, in particular to simulate enzyme-catalysed reactions. Computational modelling and simulation have the unique potential to offer detailed, atomic-resolution insight into the dynamics and reactions of biomolecules. Quantum mechanical electronics structure calculations can be useful for modelling reactions in models of enzyme active sites. Larger models can be treated with combined quantum mechanics/molecular mechanics or empirical valence bond methods, with which molecular dynamics simulations can be performed
Session 6: Enzymes in Food Technology
The enzyme used in food processing was mostly derived from animal offal and plant extracts. Most of the enzymes used are now from microbial fermentation. In general, the purity of the enzyme used in food processing does not need to be particularly high, mostly partially purified enzyme. Unless in the special applications, such as proteolytic enzymes used in low-calorie beer, the higher the purity, the better the effect. Most enzymes applied in the food processing are glucoamylase and then followed by protease, lipase, esterase, oxidoreductase and isomerase. Enzyme, from organism and made with modern biotechnology, is a pure natural biological products and green food additives. It plays a significant role in a variety of special flour production and transformation. For instance, it can improve the baking quality, nutritional quality, texture, storage resistance and other functions.
Structural Biochemistry/Enzyme. Enzymes are macromolecules that help accelerate (catalyse) chemical reactions in biological systems. This is usually done by accelerating reactions by lowering the transition state or decreasing the activation energy. These residues are called the catalytic groups. Enzymes made from artificial molecules which do not occur anywhere in nature have been shown to trigger chemical reactions in the lab, challenging existing views about the conditions that are needed to enable life to happen. A team of researchers have created the world’s first enzymes made from artificial genetic material. The synthetic enzymes, which are made from molecules that do not occur anywhere in nature, are capable of triggering chemical reactions in the lab. Enzyme systems like tyrosinases, transferases and lysyl oxidases show interesting characteristics as dynamic scaffolds and as systems for controlled release. Increased attention is currently paid to hydrogels obtained via crosslinking of precursors by transferases or peroxidases as catalysts. Enzyme-mediated crosslinking has proven its efficiency and attention has now shifted to the development of enzymatically crosslinked hydrogels with higher degrees of complexity, mimicking extracellular matrices. Moreover, bottom-up approaches combining biocatalysts and self-assembly are being explored for the development of complex nano-scale architectures. In this review, the use of enzymatic crosslinking for the preparation of hydrogels as an innovative alternative to other crosslinking methods, such as the commonly used UV-mediated photo-crosslinking or physical crosslinking will be discussed.
Enzymes are the proteins in the drug design that act as drug targets for the diseases in the process of drug discovery and development. There are number of drug targets involved in the designing of the drug. Drug target as a nucleic acid or a protein (e.g. an enzyme, a receptor) whose activity can be modified by a drug. The drug can be a small-molecular-weight chemical compound or a biological, such as an antibody or a recombinant protein. The drug target should have been shown to be effective/mechanistically involved in the disease by relevant in vitro or in vivo models.
Enzymes are the extremely selective biocatalysts synthesized by living cells. Therapeutic enzymes are those enzymes which can be used medically either isolately or adjunct with other therapies with the purpose of treatment of various diseases safely. Use of these enzymes as drugs for the treatment of medical problems forms the basis for “Therapeutic use of enzymes”. Enzyme supplements are often prescribed for patients suffering from disorders that affect the digestive processes such as Cystic fibrosis, Gaucher’ s disease and celiac disease. Enzymes have the ability to purify the blood, strengthen the immune system, enhance the mental capacity, cleanse the colon and maintain the proper pH balance in urine. Enzyme immobilization is another broad field which is applied in therapeutics. Immobilization process is to optimize the operational perforformance of an enzyme for industrial application. Immobilization improves many properties of enzymes such as performance in organic solvents, pH tolerance, selectivity, heat stability and functional stability.
Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term proteomics was first coined in 1997 to make an analogy with genomics, the study of the genome. The word proteome is a portmanteau of protein and genome. The proteome is the entire set of proteins, produced or modified by an organism or system.
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