Title: Changes of the immune status in pneumonia developed on the background of hepatitis C

Biography:

Mahira Amirova, an Assoc. Prof. In Azerbaijan Medical University, 1966. In 1988, graduated Az.Med.University pharmaceutical faculty. In 1988-1993 worked at theme "Atherosclerosis correction by tritherpenoids". PhD in biological science. Nationality: azerbaijani, Is a co-author of 2 books:"Biochemical laboratory classes" and " "Biochemistry laboratory manual and theory and methods", an editor of book "Pathological and clinical biichemistry" An author of teaching aids: "Biichemical mechanism of biotransformation and elimination of xenobiitics" An author of teaching aids: " Biochemical aspects of aging", "Some points in biochemistry and pathobiochemistry of cell", "Role of apoptosis in pathogenesis of certain diseases", "Biochemical aspects of ethanol action and metabolism", An author of annual biochemistry test-books for students of treatment, dental, pharmaceutical faculties, and test-book in clinical biochemistry. An expert in "State Comission for post-graduates"

Abstract

We investigated the relationship between pulmonary infection and antimicrobial peptides, endotoxins and lipopolysaccharide-binding protein (LBP). Lymphocyte leanages indicating the immune response determined by clusters of differentiation (CD) and changes of T-, B-lymphocytes ratio.  We tested 42 individuals with pneumonia on chronic hepatitis C background. Endotoxin and lipopolysaccharide-binding protein (LBP) were determined using the ELISA technique. Determination of the CD clusters carried out by indirect immunofluorescence reaction, while the circulating immune complexes (CIC) identified by sedimentation method with a 3.5% solution of polyethylene glycol. Statistical processing of the results carried out using the Wilkinson U-test (Mann - Whitney). We have found that in the group of patients with hepatitis aggravated by pneumonia, CD25+ lowered approximately three times. When pneumonia, indicator CD25+ correlated with severity of disease. Endotoxin elevated even up to 57.7 IU/ml, the same direction changed defensin concentration. LPB raised nearly 19 times, while defensins – about 38 times. In this study, we present our version of the involvement of immune components in self-protection in hepatitis C-associated pneumonia. Keywords: ALT, bilirubin, circulating immune complexes, defensin, Endotoxin, lipopolysaccharide binding protein