Dr. Mohamed Azize received his M.S. and Ph.D. (2006) degrees in Physics from University of Montpellier II and University of Sophia-Antipolis in France, respectively. His expertise is around semiconductor material processing & devices for micro-& opto-electronic and sensors. He has been working in world-class research laboratories since 2002: CQD Northwestern University (USA), CRHEA-CNRS and CEA labs in France, and MTL lab at MIT (Cambridge, MA USA). He has authored more than 47 scientific articles and more than 10 grantedÂ patents.Â He has been involved in multiple start ups at C- and director levels and his groundbreaking work on wide-band gap semiconductor used in HEMT and LEDs devices that have been converted to commercial products by Â French and USÂ startÂ ups. Currently he is a technical leader/manager in the Biosensor group at ADI and also is adjunct research assistant professor at Boston University in the division of Material Science and Engineering.
Statement of the Problem: This pandemic has made clear that a much improved molecular and serological diagnostic testing solution is required for preventing the spread of infectious diseases. Most current testing for the virus requires analysis by trained technicians operating expensive equipment in centralized laboratory facilities. Therefore an immeasurable need for a point-of-care test solution with minimal user operation is needed to be deployed at scale. Methodology & Theoretical Orientation: The main components of a low-cost and disposable ADI biosensor are: (1) a protein-based recognition element, which selectively interacts with a target analyte, (2) a 2D material-based transducer element, which converts the interaction into a detectable signal, and (3) ADI read-out electronics, which further process the transducer signal and produce an intelligible sensor output. This full system can be integrated into a single chip, providing a robust platform for rapid detection and quantification of biological analytes for everyday diagnosis monitoring
Sharmaine Reintar, 25 years of age, was born in the Philippines. She finished her Bachelor studies by 2016 at the University of Northern Philippines and is a Registered Medical Technologist by profession. She has 1 year (2017-2018) of experience working in a clinical laboratory setting to analyze several body fluids in the body. She got her Masters degree in nanoscience and nanotechnology at the Universitat Rovira I Virgili, Spain by 2019. She started her PhD study in 2020 at the Medical University of Graz, Austria, which is currently ongoing.
Diabetes mellitus cases are reported to increase each year, affecting approximately 463 million of people worldwide by 2019 according to International Diabetes Federation . C-peptide is a by-product of pancreatic beta cells, which is secreted in equal amounts along with insulin. One of the advantages of C-peptide is a longer half-life (30 minutes) compared to insulin (5 minutes) in the plasma. The presence of C-peptide in urine is closely linked to the metabolic situation, particularly reflecting insulin secretion . In this multidisciplinary study, we aim to develop an electrochemical immunosensor based on competition approaches for the detection of C-peptide levels in urine samples. The method is based on antigen-antibody interactions that are specific for C-peptide.
Current methods for monitoring specific molecules in the living body, such as the continuous glucose monitor, rely on the enzymatic or chemical reactivity of their targets, and thus are not generalizable to new targets. For this reason, only a handful of metabolites and neurotransmitters can currently be measured in vivo. Against this background, we are developing a molecular measurement platform that: (1) has been demonstrated able to work in the living body and (2) is independent of the reactivity of its targets and thus is general
Robert Batchelor completed both his MS in Pharmacology and BS in Biochemistry at the University of Washington in Seattle, USA. Since then, he has gained over twenty yearsâ€™ experience in the biotech industry and has launched over 50 products to market at several companies, including ThermoFisher. He is an expert on developing electrochemical aptamer-based sensors based on his experience at four startup companies in the US and Australia, including Base Pair Biotechnologies in Houston, Texas, and former wearable medicine sensing industry leader Eccrine Systems in Cincinnati, Ohio. He is currently the Head of Biosensors at Nutromics in Melbourne, Australia
Dr. Anupam Mukherjee has a multidisciplinary background of achievements in synthetic organic chemistry, material science for optoelectronic applications and silicone materials & technology and its production and diverse applications. Currently, in General Silicones as Technical Director of R&D Center, he is engaged in corporate entrepreneurship to develop new ideas and opportunities within established business and carrying out investigations on design and development of various innovative large-scale manufacturing of high value- added silicone products following multi manufacturing processes
Biosensors are nowadays omnipresent in medical analysis along with their present in other areas like daily healthcare monitoring, food safety and control, drug delivery systems, wound healing, human physiological signal monitoring and ongoing medical research [1-2]. The global pandemic COVID-19 and it’s worldwide social and human life destruction has shown us, how remote heath care monitoring, digitally health management, physiological signal monitoring etc. are the burning needs of the hour. For the accuracy and comfort of the patient for disease diagnosis, monitoring and treatment, it’s very essential to have a flexible, sensitive, robust, conformable, portable and bio-compatible platform to design the flexible hybrid electronics for bio sensing. It’s also important to rethink and design the rapidly emerging printed and flexible E-skin electronics on a sustainable novel material as well as circular platform that will minimize E-waste and GSG emissions at the very beginning stage of innovation
Ana Domingues has completed his Mater at the age of 23 years from University of Minho (Portugal), in Erasmus context in University of Freiburg (Germany). She worked almost one and half years as Biomedical Engineer. Currently, she is Project Engineer at Active Space Tecnologies in Coimbra, Portugal
In Biomedical Engineering, inductive wireless power transfer (IWPT) has been investigated by many researchers to charge active implantable medical devices (AIMDs) since IWPT is safe and avoids the implementation of cables, preventing infections through the skin and movement limitations. This research develops a high coverage inductive interface to build a cage that works as a tool to acquire and study the neuronal activity in small animals. The coverage is constituted by big transmitter coils in order to charge homogeneously implants in free-moving small animals, where the receiver coil is fully implanted. Different approaches, as the implementation of bigger coils, segmentation technique, multicoil array were combined to maximize the covered area and optimize the power distribution homogeneity as well as the power transfer efficiency.
Dr Yuvaraja Visagathilagar has over 26+ years of extensive expertise and experience in academia, research and industry. He graduated with Bachelor of Engineering in Communication Engineering and Doctorate in Engineering (with a highly prestigious scholarship from the Australian Government) in 1996 and 2003 respectively from RMIT University, Melbourne Australia. His dissertation was in “Narrow-band Optical Modulator on Lithium Niobate” for telecommunication applications but it can be applied for other transceivers applications.
For many decades, sensing has been a key global application for many commercial and defence applications . Early sensing technologies has been using either electrical (or RF/Microwave) technologies however, in recent global research and development has focused on smart optical sensing technologies. Predominantly these technologies provide: (a) compact and robust (b) immunity to electromagnetic interference; (c) use of low cost telecommunication fibre cables; (d) long distance; and (e) not susceptible to harsh environment [1, 2] (f) ease of manufacture and other factors. The optical sensing technologies have been applied for leak detection, vibration/perimeter detection and health monitoring due to its high sensitivity and localisation with sub-metre spatial resolution. In traditional optical sensing technologies have been used in monitoring of large-scale perimeter and pipeline monitoring  due to the cost of the technology.
Bruno Le Pioufle, PhD from University Paris XI, is Professor at ENS Paris-Saclay, within the University Paris-Saclay. He is the Director of Institut d’Alembert. He is author of more than 70 papers in scientific journals
Red blood cell (RBC) genetic disorders affect millions of peoples in the world. Abnormal hemoglobin (HbS) is produced and fills the denuclearized RBC. Under hypoxic condition, HbS polymerizes and RBC with a diameter of 8µm loses its elasticity and deformability to pass through the blood microcapillaries network. Such disorder can be found for example in Sickle Cell Disease (SCD), and might induce vaso-occlusive and organs dysfunction. For the abnormal RBCs detection, bioimpedance measurement of cells injected into a microfluidic device is proposed. Electrically monitoring the transit of RBC in the microfluidic network, comprising fluidic restrictions, the RBCs of different pathological states can be discriminated. The device was made in Polydimethylsiloxane (PDMS) casted thanks to soft lithography technology.
Maria Isabel Gaviria Arroyave, currently Ph.D. (c) in Environmental Engineering at Universidad de Antioquia and CEO of Taxia mentoring start-up. Degree in Biological Engineering from Universidad nacional de Colombia and Master in Engineering from Universidad de Antioquia. Up to 10 years of experience in innovation and development processes, applying cutting-edge technologies like environmental biotechnology and green nanotechnology. Previous positions in R&D manager at Universidad EIA and Biotechnology chief in SENA. Senior consultant in innovation and circular economy for Taxia mentoring and Distilled innovation. National doctoral fellowship from Minciencias (2018-present) and Swiss government fellowship from University of St.Gallen (AIT program 2020-2021).
Water sources in rural areas are exposed to harmful Organophosphorus pesticides (OP) that should be detected before human consumption , and biosensors have emerged as an alternative . The application of nanomaterials, including carbon quantum dots (CD), can significantly improve the performance of optical biosensors. In this work, naturally fluorescent and non-toxic CD synthesized previously from African-oil palm biochar were integrated with Acetylcholinesterase enzyme (AChE) as a bioreceptor, to produce a fluorescent biosensor. This system is modulated with graphene oxide (OG), showing a fluorescence recovery in the presence of the OP. The biosensor was evaluated under pure chlorpyrifos, but also under a commercial formulation called Lorsban®. We obtained a limit of detection (LOD) as low as 0.13 ppb and 2.14 ppb for chlorpyrifos and Lorsban® respectively. The system also shows a good selectivity against proteins and other organic substances usually present in drinking water, even in tests with tap water.
Juan Pablo Arango is currently a Researcher in the GIBEC research group at EIA University in Colombia. Prior to his recent position, he was a visiting scholar in the department of Physiology at the University of Kentucky. He received his bachelor’s in biomedical engineering from EIA University in December 2018 and is currently finishing his master’s in biomedical engineering also from EIA University. He is currently the director of the Technologies for the detection of biomolecules hotbed of research in EIA University, where he hopes to involve and train undergraduate students in the research process
The present study developed an optical biosensor based on Carbon Dots (CDots) obtained from Elaeis guineensis biochar, for the detection of a model molecule, in this case, Bovine albumin serum (BSA). The CDots had a size of 2.5 ± 0.7 nm determined through a High-Resolution Transmission Electronical Microscopy (HR-TEM), a Z potential of -56.1 ± 2.37 mV and a Quantum yield of 1.69%, with emission and excitation wavelengths of 428 and 320 nm, respectively. As a bioreceptor molecule, the anti-BSA was used and conjugated to the CDots surface using the carbodiimide method. The fluorescence of the CDots was evaluated through a fluorescence spectroscopy and posteriorly modulated using graphene oxide. Finally, the performance of the biosensor was analysed by evaluating the specificity and sensitivity, where a qualitative biosensor was obtained that detects in a range of 1000 - 10 mg / µL of BSA. With the implementation of this technology, it will contribute to the improvement of the quality of life of Colombian vulnerable populations while contributing to the closing of cycles of the oil palm industry.
Laure Abensur Vuillaume is emergency physician (M.D) and has completed his PhD in biological science from Lorraine University (France). She works and develops expertise in applied health technologies and medical education
To improve the efficiency of current medical practices, more significant data from technology is needed. One lever to optimize medical decision time is to shorten the delay from biological test to results. In the field of fast biological tests, biosensors have received increasing attention and several technologies have been developed to deliver portable, cheap and sensitive analytical systems(1,2). Nevertheless, two main obstacles prevent the marketing of these biosensors: 1) an accurate analysis of the market in terms of real needs for medical practices and 2) perfect matching with current medical recommendations