July 18-19, 2019


Zurich, Switzerland

Conference Agenda

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Keynote Session:

Meetings International -  Conference Keynote Speaker Julio C. Vega  photo

Julio C. Vega

Laboratorio Pablo Cassara SRL

Title: Preservation in medicines, a QbD approach to optimize microbiological quality of pharmaceutical formulations


Julio C. Vega has graduated in Chemistry at the University of Buenos Aires. He holds a degree as Master of Industrial Business Administration from Escuela de Organization Industrial de Madrid and a postgraduate degree in Industrial Business Administration from University of Catolica, Argentina. He is R&D Manager at Laboratorio Pablo Cassara S.R.L., a pharmaceutical company in Argentina. He is author and co-author of patents related with pharmaceutical formulations and pharmaceutical primary packaging materials. 


Preservatives have long been used in the formulation of liquid and semisolid medicines to ensure microbial quality during their shelf life and use. However, preservatives may cause undesirable effects both topically and systemically and even contribute to antibiotic resistance of microorganisms. Therefore, they should be either avoided or minimized. Within the present regulatory framework of Quality by Design recommended by ICH guidelines, a decision-tree approach is proposed to either avoid or minimize the use of preservatives. An optimization procedure to find the optimal concentration of preservative is described, on the basis of the works of Orth DS. It consists of criteria for the selection and estimated concentration ranges of preservatives for a certain formulation coupled with a procedure to estimate D values for different microorganisms. D value is a quantitative measure of preservative efficacy of the formulation, allowing the use of regression analysis to optimize preservative concentration and other formulation parameters, thus accelerating and improving the process of formulation development.

Oral Session 1:

  • Advances in Pharmacological Research | Applied Pharmacology | Pharmacokinetics and Pharmacodynamics
Meetings International - Pharmacology 2019 Conference Keynote Speaker Nika Oman Kadunc photo

Nika Oman Kadunc

REDSTART Instrumentation Ltd, Slovenia

Title: New possibilities in real-time quality control with new generation machine vision technology


Nika Oman Kadunc completed her degree in Physics in 2009 at the University of Ljubljana. She participated in several research and development projects involving software development, machine vision algorithms and industrial sensor development. 


The aim of improving the quality of pharmaceutical end products and optimizing production efficiency drives the need for progress in real-time quality control with process analytical technology (PAT) tools for monitoring critical quality and performance attributes. Multiparticulate dosage forms – using coated or uncoated pellets or granules – are increasingly used in the production of solid dosage forms as they enable favourable release profiles of active ingredients. With these, the Critical Quality Attributes (CQAs) that affect the physicochemical properties of drug substances and final dosage forms are particle size, particle shape and, with coating applications, also coating thickness and coating uniformity. The machine vision technology brings advantages over other PAT techniques as it provides means of contactless, non-invasive, non-destructive, fast and accurate automatic measurements of particles together with easy implementation and calibration. The benefits of the presented PAT technology offer new possibilities for optimizing and a better understanding of production processes and, subsequently, of the end product quality assurance.

Meetings International - Pharmacology 2019 Conference Keynote Speaker Kholoud Sami Alsowayigh photo

Kholoud Sami Alsowayigh

Jeddah Forensic Medicine center, Saudi Arabia

Title: Evaluation of alcohol concentrations in samples taken from medico legal cases referred to Jeddah forensic center KSA


Kholoud Sami Alsowayigh works as a Forensic consultant at Jeddah Forensic Medicine center.


The present study investigated the level of alcohol in cases referred to the centre as a post mortem cases and to the assault clinic from 2014 -2018 detection of alcohol is of extreme importance to the investigation and the cause of death. To evaluate the problem on alcohol intake and its relation to nationality, age, and gender and cause of death. Samples used for testing alcohol level: vitros fluid, blood, urine. Alcohol intake in Saudi Arabia is banned, this includes consuming, importing, brewing and selling so all cases suspected for drinking alcohol are referred to the toxicology centre and the forensic centre.

Meetings International - Pharmacology 2019 Conference Keynote Speaker Sapana P. Bansod photo

Sapana P. Bansod

NIPER, India

Title: Nimbolide abrogates cerulein-induced chronic pancreatitis by modulating Wnt/β-catenin/Smad in a Sirtuin 1-dependent way


Sapana Bansod is a PhD student in the Department of Pharmacology and Toxicology at NIPER Hyderabad, India’s Pioneer Pharmaceutical Research Institute. She has Proficient knowledge and expertise in acute and chronic pancreatitis, liver fibrosis, genotoxicity and molecular biology. Her current research includes exploration of novel pharmacological interventions in cerulein-induced pancreatitis. She has first time developed and standardized the short-term chronic pancreatitis model in swiss mice. She is highly motivated, enthusiastic experimental pharmacologist.


Chronic pancreatitis (CP) is characterized by pancreatic inflammation and fibrosis, which leads to impairment of pancreas function. The present study was designed to investigate the possible mechanisms of chronic pancreatitis and the anti-inflammatory, antioxidant and anti-fibrotic effect of nimbolide (NB), active constituent of neem tree Azadirachta indica in cerulein-induced CP. 

Keynote Session:

Meetings International -  Conference Keynote Speaker Tarek K. Motawi photo

Tarek K. Motawi

Cairo University, Egypt

Title: Chemomodulatory effect of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption in rats


Tarek K. Motawi Faculty of Pharmacy, Cairo University. He has completed his PhD in Pharmaceutical Sciences.


Paracetamol and diclofenac are two of the most popular analgesics and anti-inflammatory medications. Despite of their several therapeutic benefits, their over consumption led to subsequent cellular damage. Their cytotoxicity is attributed to reactive radical generation. Betanin has antioxidant and anti-inflammatory properties. The protective effects of betanin against paracetamol or diclofenac induced neurotoxicity or endocrine disruption has not been investigated before. Therefore, this study aims to explore the protective potential of betanin against paracetamol or diclofenac neurotoxicity and endocrine disruption in a rat model. In brain, paracetamol (400 mg/ kg) and diclofenac (10mg/kg) enhanced DNA fragmentation and lipid peroxidation level. A depletion of GSH content concomitant with a reduction in the activities of antioxidant enzymes (HOX-1, POX-1, CAT and SOD) were detected. Serotonin, nor-adrenaline and dopamine levels were markedly reduced after paracetamol and diclofenac challenge. In serum, a significant reduction of testosterone, TRH, TSH, T3 and T4 were associated with the enhanced oxidative damage. Co-treatment of rats with betanin (25mg/kg) by gavage for 28 consecutive days ameliorated most of the biochemical and histopathological changes induced by paracetamol or diclofenac. In conclusion, betanin exerted a potential chemomodulatory effect against paracetamol or diclofenac overconsumption induced neurotoxicity and endocrine disruption.

Oral Session 1:

  • Drug Screening and Discovery | Pharmacogenetics and Pharmacogenomics
Meetings International - Pharmacology 2019 Conference Keynote Speaker Muhammad Bilgary Utama  photo

Muhammad Bilgary Utama

Bandung Islamic University, Indonesia

Title: Comparison of Health Effects of Water which Purified by Poly-Glu Powder, Demineralised Water and Alcohol for Daily Consumption


Muhammad Bilgary Utama is a pharmacy student in Bandung Islamic University, Indonesia. He is accomplishing his Bachelor Program. He had become Team Expert Staff of External Division in ISMAFARSI Organization.


In this study, the author realized on this day mineral water is not the only one daily consumption drink. There are so many drinks such as juice, wine, beer, and demineralised water in some regions with limited clean mineral water sources. Researchers always try to find an innovation to accomplish drinking problems on the world. In that case, researchers had found Poly-Glu Powder to be water purifier. Poly-Glu Powder had been experimented to dirty water and showed a good result, the water became clean and researchers said safety to be consumed. In the other hand, the purified water needs to take medical test continoustly to ensure the result and it could show the effect to the body pharmacologically. In consideration of purified water display couldn’t be the only one parameter that the water is safety or not, as an example alcoholic drinks have a good display and people assumed it’s safe however alcohol had been experimented how it affects our body and the result showed it affected to Blood Brain Barrier and leads to BBB Impairment by losing its integrity (Brain Microvascular Endothelial Cells). This study leads to compare the Poly-Glu Powder innovation to alcoholic drinks which usually consumed in developed countries and demineralised water which became primary drinks for limited water sources countries or poverty people. Therefore, World Health Organization (WHO) had published their report in 2004 that consuming demineralised water may give adverse health effects and decreasing mineral intake also other essential elements and microelements in the body.

Meetings International - Pharmacology 2019 Conference Keynote Speaker Mohamed E.E. Shams photo

Mohamed E.E. Shams

University of Mansoura, Egypt

Title: Pharmacogenetics in clinical practice: Are we ready for the era of personalized medicine?


Mohamed E.E. Shams is a professor at Faculty of Pharmacy at University of Mansoura in Egypt. He earned his PhD in clinical pharmacy and pharmacy practice from the Faculties of Pharmacy and Medicine at Johannes Gutenburg University of Mainz in Germany. His pharmacy experience includes practice in patient care, clinical pharmacogenetics, clinical pharmacokinetics, therapeutic drug monitoring, pharmacoeconomics, medications errors, drug-interactions, long term care and hospital settings. He has many papers and projects either presented or published in reputed journals. He is an internationally recognized expert in many areas of clinical pharmacy, pharmacy practice and pharmaceutics. 


Personalized medicine is a rapidly advancing field of health care. It means the prescription of specific therapeutics best suited for an individual based on pharmacogenetic and pharmacogenomic information. Cytochrome P450 2D6 (CYP2D6) is an example of a polymorphic isoenzyme which is involved in the oxidative metabolism of numerous commonly prescribed drugs, including many antiarrhythmics, β-blockers, neuroleptics, selective serotonin reuptake inhibitors (SSRIs), and tricyclic antidepressants. Total deletion of the CYP2D6 gene or mutations may lead to an inactive or less-active enzyme. Patients who are taking drugs that are CYP2D6 substrates and who have such mutations may have elevated drug levels and drug toxicity. Conversely, gene duplication or multiplication is thought to lead to increased enzyme production, which results in an increased rate of drug metabolism and failure of treatment.

Meetings International - Pharmacology 2019 Conference Keynote Speaker Renu Mishra  photo

Renu Mishra

Sri Sathya Sai College for Women, India

Title: Phytochemical analysis of Leaves of Coleus aromaticus Benth. and its antibacterial activity against Staphylococcus aureus


Renu Mishra has completed her PhD at the age of 25 from Barkatullah University, Bhopal, India. She has published more than 50 papers in reputed journals and guiding more than 10 students for Doctoral work.


The expanding bacterial resistance to antibiotics has become a growing concern worldwide. Increasing bacterial resistance limits therapeutic options and hence attention has turned towards plants as alternative therapy against resistant strains. The search for antibiotic resistance modulators in plants represents a new dimension to addressing the problem of antibiotic resistance. Medicinal plants are promising and offer considerable potential for the development of new agents effective against infections currently difficult to treat. Medicinal plants, since time immemorial have been used as a source of medicine in most parts of the world. Leaves of plant Coleus aromaticus Benth were taken for herbal drug potential studies belonging to Lamiaceae family. In India, the plant is commonly known as Patharchur. In the present study Staphylococcus aureus bacteria was isolated from the sputum samples of T.B. negative patients. Phytochemical analysis of leaves was done in acetone, aqueous, ethanol and methanol solvents. Results showed that, leaves have flavonoids, saponin, phenolic compound, diterpenes and carbohydrates. The antibacterial activity of Coleus aromaticus was evaluated against human pathogenic bacteria Staphylococcus aureus by well diffusion method. It has been observed that all solvent extract exhibit antibacterial activity. The alcoholic extract showed maximum activity followed by aqueous extract while acetonic extract exhibit minimum antibacterial activity against Staphylococcus. From this study it is concluded that leaves of Coleus are effective in the inhibition of Staphylococcus aureus growth in vitro conditions.