Explore your options to connect, learn and be inspired from our speakers
Title: KNOWLEDGE AND PRACTICE OF PHYSICALACTIVITY AMONG PREGNANT FOLLOWING IN PRIMARY HEALTH CARE CENTERS IN THE EASTERN PROVINCE
Dr.Arij A Al-Thebaiti
Family medicine consultant
Adolescent Health speciality
Member of Saudi Board of Families Medicine Exam committee
Former Head of Family Medicine Department
Pregnancy is a great time to evolve healthy lifestyle habits including regular exercise. Physical exercise programs for pregnant women are praised and are steadily rising in popularity. The benefits included preservation of prenatal aerobic and musculoskeletal fitness levels, prevention of excessive maternal weight gain, facilitation of labor, help for gestational glucose control and improved psychological adjustment to changes of pregnancy (1). Numerous Health benefits of physical activity during pregnancy were documented such as reduced risk of excessive gestational weight gain and conditions such as gestational diabetes, preeclampsia, preterm birth, varicose veins, and deep vein thrombosis. Evidence showed that physical activity during pregnancy is associated with a reduced length of labor and delivery complications. Psychological benefits of physical activity during pregnancy include reduced fatigue, stress, anxiety, and depression, as well as improved well-being. Physiologic responses to exercise, such as changes in heart rate, cardiac output, ventilation, and energy expenditure, are all greater during the antenatal phase than before conception and may become more pronounced as pregnancy progresses. (2). The World Health Organization's guideline on physical activity recommends that adults age 18 to 64 years should practice at least 150 minutes of moderate intensity aerobic activity throughout the week, or at least 75 minutes of vigorous-intensity aerobic activity, or an equivalent combination of the two (3). Most pregnant ladies don't engage in any form of exercise and tend to decrease their level of physical activity, including household and occupational activities. Pregnant women have cited discomfort during practice, fear of harm to the fetus, and a history of abortion or infertility treatments as reasons for reducing physical activity. Among sociodemographic factors, lower educational level and income, a greater number of children at home are most frequently associated with the reduced physical activity (4).
In December 2015, the American College of Obstetrics and Gynecology (ACOG) published updated physical activity (PA) guidelines for pregnant women, recommending women with uncomplicated pregnancies engage in ≥20–30 minutes/day of exercise on most days/week (5). The physical activity level in Saudi Arabia is low as a study conducted on 2007 showed that 98.1% of Saudi females are sedentary (6). JUSTIFICATION In Saudi Arabia the practice of exercise is of low prevalence, advocacy of physical exercise among women in general and pregnant ladies indeed are highly required at national and local levels. After reviewing literature, we noticed that there were no studies on physical activity among pregnant ladies in Saudi Arabia despite the importance of exercise on the health of both the mother and the baby. We decided to conduct our research in order to estimate the prevalence of physical activity among pregnant and relate to the factors that could be responsible for low prevalence and make suggestions in order to promote such as healthy and cost effective intervention. Research Question: How can the knowledge of pregnant following in PHCC affect their practice of physical activity during pregnancy? GENERALOBJECTIVE: To assess the knowledge and practice of pregnant women regarding physical activity during their pregnancies in the eastern province (AlKhobar, Dammam & Al-Qatif) Saudi Arabia. SPECIFIC OBJECTIVES:
1. To assess the knowledge and practice regarding physical activity in pregnancy.
2. To assess the prevalence of physical activity in pregnant women attending PHCC.
3. To estimate the relevant factors related to physical activity during pregnancy.
Oral Session 1:
- Midwifery: Innovation, Practice and Research
Oral Session 2:
- Gynaecology and Obstetrics
Title: An exploration of the proteomic landscape of unexplained female infertility using bioinformatics
Female unexplained infertility is a multifactorial disorder with poorly understood pathogenesis with underlying mechanisms. Around 50% of infertility cases are caused solely by female factors, with 15-20% having no identifiable cause, making it a primary challenge for reproductive medicine experts for decades. Among all omic procedures, proteomics is now being widely used in the field of human reproduction. In recent years, the literature on the proteome database connected to various reproductive tissues in males and females has been enhanced by the availability of improved proteomic methods and databases. Further, Network and pathway analysis using bioinformatic tools has now provided a more scholastic and comprehensive view of the potential pathways connected to the significantly elevated DEPs (Differentially Expressed Proteins) to identify their relevance to specific infertility circumstances. This study investigated differential tissue proteome profiles in patients with unexplained female infertility and healthy fertile controls and explored the association between their tissue proteomes. Paired samples of ten patients with unexplained infertility and ten healthy fertile controls during their mid-secretory phase (LH +7) were obtained for optimized quantitative tissue proteomics analysis. High-resolution two-dimensional gel electrophoresis (2-DE) analysis was used for comparing patterns of protein expression, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to identify protein spots on 2-DE gels (MALDI-TOF MS). The presence of upregulated DEPs were then validated against their respective primers using the qPCR technique. To interpret and analyze the collected data in light of their biological function, pathway, and interaction network, bioinformatic software and tools, including UniProt, Genecards (v.4.8.2), KEGG, Reactome, and STRING were utilized (version 10.5). Using PANTHERS 14.0, the genes corresponding to differentially expressed proteins were mapped to multiple gene annotation data and the biological pathway. Molecular function, biological process, cellular location, and protein class was done. We identified twenty four proteins differentially expressed in Infertility when compared with healthy controls, including Ankyrin repeat domain-containing protein 36A (ANKRD36), Zinc finger protein 658 (ZNF658B), MAM and LDL receptor class A domain containing 1(MALRD 1) and proline-rich coiled-coil 2A (PRRC2A). There appears to be an interesting strong association among the genes of three metabolic enzymes: between Zinc finger CCCH domain-containing protein 13 and Putative RNA-binding protein 15 and between homologues of Hemoglobin subunit beta- HBB and HBA1 (combined score: 0.781), HBB and HBA2 (combined score: 0.560) and HBA1 and HBA2 (combined score: 0.800). In addition, PRRC2B co-expresses with ERCC6, CNTLN co-expresses with ANKRD36; ZC3H1D co-expresses with EIF2AK2; CAMSAP2 co-expresses with EIF2AK2; and EIF2AK2 coexpresses with LAMA3 not only an interaction between EIF2AK2, CAMSAP2, LAMA3 and ANKRD36 but also a possible association between them and unexplained female infertility was noted. The enrichment study identified 25, 20, and 114 pathways among KEGG, WiKi, and Reactome databases, respectively indicating the key role these proteins play in causing the morbidity associated with infertility. Further understanding of the underlying causes and the mechanistic pathways of unexplained female infertility is needed to better comprehend the disease and its management.