Pharmaceutics is the applied science of dosage form design. In that preformulation study is a stage of development process in which the physicochemical properties of drug substance are characterized. These Preformulation studies are an important component of drug development wherein it helps development of formulations, for various stages of clinical trials. It provides the scientific basis for formulation development. It assists scientists during screening process of lead candidates based on their physicochemical and biopharmaceutical properties. This data is useful for selection of new chemical entities (NCEs) for preclinical studies which is a major section of drug development.
Formulation is the process in which different chemical substances i.e. active pharmaceutical ingredient will combined with other excipients to produce a medical compound. The instability nature of the new drug changed its desired form into undesired form when it is combined with other excipients. Now-a-days numerous advancements have been achieved in this field which in turn aids to save the time and money and encounter the challenges during formulation development.
Drug delivery is the method or process of administering pharmaceutical compound to achieve a therapeutic effect in humans or animals. Many medications such as proteins and peptides, antibody, vaccine and gene based drugs, may not be administered by these routes because they might be susceptible to enzymatic degradation due to molecular size etc. The conventional dosage forms provide drug release immediately and cause fluctuation of drug level in blood depending upon dosage form. Therefore to maintain the drug concentration within therapeutically effective range needs novel drug delivery system. NDDS is advanced drug delivery system which improves drug potency, control drug release to give a sustained therapeutic effect, provide greater safety finally it is to target a drug specifically to a desired tissue. NDDS is a combination of advance technique and new dosage forms which are far better than conventional dosage forms. Modes of NDDS are; Targeted Drug Delivery System, Controlled Drug Delivery System, Modulated Drug Delivery System
Pharmacokinetics is the study of how is the drug absorbed, distributed, metabolized and excreted in the body. Population pharmacokinetics is the study of pharmacokinetic differences of a drug in different population groups. Clinical pharmacokinetics is defined as the applications of pharmacokinetic principles in the safe and effective management of individual patient. Toxic kinetics is defined as the applications of pharmacokinetic principles to the design, conduct and interpretation of drug safety evaluation studies.
Pharmacodynamics is the study of the impact of drugs on the body; the primary focus is the mechanisms by which the drugs exert their therapeutic & adverse effects. As the dose changes the type and degree of the response changes. Bioavailability is the proportion of the administered dose that reaches the systemic circulation.
The new drug target discovery and exploitation is a key for both the pharmaceutical industry and academic research. To ensure an insight into trends in the exploitation of new drug targets analysed the drugs that were approved by the US Food and Drug Administration.The main drawbacks in systemic drug administration are Lack of drug affinity towards the pathological site and nonspecific toxicity and other adverse effects so drug targeting may resolve some these problems. Drug target can serve both as a therapeutic approach and research tool in normal physiology and under patho-physiolocal conditions. Computer Aided Drug Design is the tool used to predict whether the small molecule will bind the target site and how strongly bind to the binding site. Molecular mechanics and molecular dynamic studies also used to estimate the interaction strength between the drug molecule and the binding site.
Route of administration is the way by which the drug molecule entering into the body. Route of administrations are basically classified based the application location of the drug molecule.The differences in routes of administration of various drugs, and the regional differences in routes of use, have implications for the provision of preventive and treatment services. Needle exchange schemes and interventions targeted at drug overdose may be more suitable in areas of high injecting prevalence. Further research into regional differences in routes of drug use should be conducted with non-clinical samples.
A nano drug delivery system contains a core, a particle or emulsion prepared by chemical methods act as a carrier. Therapeutic molecules and ligand are added to the core for targeting specific site. Nano drugs are distributed throughout the body via nano sized capsules. The major targets in the development of nano drugs are specific drug targeting and delivery, more safety and biocompatibility, rapid development of new medicine with a wide safety margin; and improved pharmacokinetic properties, Theoretically, nanodrugs can easily pass through the fine capillary blood vessels and the lymphatic endothelium, higher binding capability and accumulation at target sites, In particular, nanotechnologies have been used to develop site-specific drug targeting, for the treatment of brain diseases and cancer.
Nanotechnology can be defined as a technology which can deals with study and manipulation and developing and designing particles, biomolecules of the size less than 100nm and more than 1nm with the aim of modification enhancement, lowering a particular property of a molecule or particle further which can be used in developing molecule or device.
Nanotechnology is an amalgamation of engineering science and medical sciences. Drug delivery is the one of the most promising fields of nanotechnology. Nanotechnology in drug delivery epitomized by liposomes, nanogels, Dendrimers, nanocarriers, Silicon or carbon materials, Gold nanoparticles, Fullerenes, and Magnetic nanoparticles
Pharmaceutical Nanotechnology has wide applications like nanoemulsions enhancing the absorption of a drug in particular site, increasing the microbial stability of product, to develop the molecules as tracer maker in identifying the toxic materials. A large number of nanosystems have been found in pharmacy field today are liposomes, metallic nanoparticles, polymeric nanoparticles, carbon nanotubes, quantum dots, nanofibres etc. It provides opportunities to improve materials, medical devices and help to develop new technologies where existing and more conventional technologies may be reaching their limits.
Smart drug delivery system (SDDS) is the multi targeted, pH responsive, Stimuli sensitive delivery systems in which delivering the medication to a patient in a manner that increases the concentration of the medication in some parts of the body. Smart drug delivery systems are the future and developing effective delivery systems. Nanotechnology based smart drug delivery systems are proved efficient in diagnosis and treatment of various diseases.
Targeted drug delivery system is a special form of drug delivery system where the the pharmacologically active agent selectively targeted or delivered its site action. It has been developed to optimize regenerative techniques. The system is based on a method that delivers a certain amount of a therapeutic agent for a prolonged period of time to a targeted site of action within the body.
A biomaterial is any substance other than drug or combination of substances, synthetic or natural in origin. It can be used for any period of time or as a part of a system which treat diagnosis or replace any part of the body. It is used to prepare biomedical device or bio implant that is used to treat, replace or augment any tissue or organ in the body. Biomaterials are also used every day in dental applications, surgery, and drug delivery. A biomaterial is also an autograft, allograft used as a transplant material. ECM and ECM-like materials, or ECM-synthetic polymer hybrids, used as biomaterials in the field of regenerative medicine,
Vaccine is a material that can produce an immunologically mediated resistance to a disease. Vaccines are prepared by killed or attenuated microorganisms. Vaccine drug delivery systems are getting popularity due to benefits they offer. Needle free technology, edible vaccines used for oral delivery of vaccines. Reason behind development of vaccines as controlled drug delivery systems are ; 1) Immunization failure with conventional immunization regimen, 2) Allow for the incorporation of doses of antigens so that booster doses are no longer necessary as antigens are released slowly in a controlled manner 3) Control the spatial and temporal presentation of antigens to the immune system there by promoting their targeting straight to the immune cells.
Theranostics is defined as the combination of diagnostics and therapeutics. In this technology radio-nuclide labeled agents are used to diagnose the disease and subsequently use identical agents to treat the disease itself. Now-a-days this technology used in the cancer treatment as cancer theranostics. Theranostic nanomedicine may be defined as nanomedicine that combines diagnostics with therapeutics. Nanotheranostics is to apply and further develop nanomedicine strategies for advanced theranostics. It can also produce stimuli-responsive release, synergetic and combinatory therapy, siRNA co-delivery, multimodality therapies, oral delivery, delivery across the blood-brain barrier.
Proteins and peptides are the most abundant components of biological systems. Peptides and proteins are attracting increasing in attention as therapeutics. Transdermal peptide therapeutics avoids the problems with GI tract. The clinical peptide therapeutic pipeline composed of 128 peptide therapeutics. The recent advances in the peptide and protein drug delivery systems are PEGylation and Depo-foam technology. Cell-penetrating peptides (CPPs) act as cargo carriers and constitute a current hotspot in medical research. CPPs to transport hydrophilic macromolecules into cells, thus, assist to execute biological functions. CPPs do not destroy the integrity of the cell membranes, and are considered more efficient and safe and providing new avenues for research and applications in life sciences.
Meetings International proudly announces the Global Experts Meeting on Pharmaceutics & Drug Delivery Systems (Pharmaceutics Meeting) scheduled durign October 12 to 13, 2017 at Osaka, Japan. With a theme of "Novel approaches, trends and challenges in Drug Delivery Systems".
The popularity of Formulation and Drug Delivery has increased significantly in recent years. The Drug Delivery Technology market is expected to reach USD 1,504.7 Billion by 2020 from USD 1,048.1 Billion in 2015, growing at a CAGR of 7.5% from 2015 to 2020. Drug delivery technology market offers a promising approach for the delivery of various kinds of drugs that have different molecular formulation. Drug delivery technology is aimed at maximizing the drug delivery at the targeted site so as to increase the efficiency of drug and proposing improved patient compliance.
Pharmaceutics Meeting will bring together key decision makers and innovators within this rapidly growing field. This intensive 3-Day program will examine various formulation and drug delivery strategies. The event will cover Pre-Formulation, Formulation Aspects, Pharmacokinetics and Pharmacodynamics, Drug Targeting, Drug Delivery Routes, Nano Drug Delivery Systems, Nanotechnology in Drug Delivery, Pharmaceutical Nanotechnology, Smart Drug Delivery Systems, Applications of Biomaterials, Theranostics and Peptides and Protein Drug Delivery.
Additionally, the event will examine novel strategies for improving Vaccine Drug Delivery Systems, including stability and half-life will also be discussed along with novel routes of administration. Case studies will be presented that illustrate the progress made in developing efficacious drug therapeutics, while leaders in the field point the way to the future for these promising drugs.
Join the industry’s leading drug development executives from numerous leading organizations to discuss and hear unique take-home examples, case studies and multiple drug development and delivery strategies to assist in reducing time-to-market on future drug products.
Attend to gain an unmatched experience in the Drug Delivery field.
Meetings International Pharmaceutics Meeting will offer you an unmatched attendee experience. In addition to the many scientific sessions and take-home case study examples, you will leave this event with many other novel development strategies from some of our workshops and symposiums. Engage in dynamic conversation with your industry peers at our multiple networking sessions, and takeaway novel drug development and commercialization strategies, which could speed up time to market and save your organization millions. We hope you will join us in Osaka, Japan this October to enhance your drug delivery capabilities, and increase time to market on therapeutics.
CEO and Founder
Meetings International PTE LTD.
Title: “Global Experts Meeting on Pharmaceutics & Drug Delivery Systems”
Date & Venue: July 31-Aug 01, 2017 at Melbourne, Australia
Theme: "Novel approaches, trends and challenges in Drug Delivery Systems"
Summary of Pharmaceutics Meeting 2017 Conference:-
Meetings International provides a Global Platform for Pharma, Biotech, Medical and Healthcare Professionals to Exchange Ideas, Knowledge and Networking at its 100+ International Conferences. The event brings together truly innovative thinkers who are leading the way through trialing new disruptive solutions and rethinking the conventional formulation and delivery mind-set and will help you to better understand how to develop the right formulation and delivery strategy with a strong scientific, clinical and commercial mind set and how innovative scientific techniques, emerging technologies and innovative devices can transform formulation and drug delivery.
Scope and Importance:-
Pharmaceutics is the applied science of dosage form design and is the discipline of pharmacy that deals with the process of turning a new chemical entity (NCE) or old drugs into a medication to be used safely and effectively by patients. There are many chemicals with pharmacological properties, but need special measures to help them achieve therapeutically relevant amounts at their sites of action. Pharmaceutics helps relate the formulation of drugs to their delivery and disposition in the body. Pharmaceutics deals with the formulation of a pure drug substance into a dosage form. Pharmaceutics Meeting will bring together key decision makers and innovators within this rapidly growing field. This intensive 3-Day program will examine various formulation and drug delivery strategies. The event will cover the following topics.
The popularity of Formulation and Drug Delivery has increased significantly in recent years. The Drug Delivery Technology market is expected to reach USD 1,504.7 Billion by 2020 from USD 1,048.1 Billion in 2015, growing at a CAGR of 7.5% from 2015 to 2020.
Melbourne is the second-largest city in Australia and the capital of the state of Victoria. The metropolis is located on the large natural bay of Port Phillip and expands into the hinterlands toward the Dandenong and Macedon mountain ranges, Mornington Peninsula and Yarra Valley. Located on the southern coast of Australia’s eastern seaboard, Melbourne is perhaps Australia’s most cultured and politically conservative city. Melbourne features include Victorian-era architecture, bounteous cultural institutions museums, art galleries, theatres and spaciously landscaped parks and gardens. Its 3.5 million populations are multicultural and entirely sports-mad.
Melbourne is a style-setter with some of the best shopping and nightlife in Australia. Whether you are searching for haute couture or vintage clothing, sparkling chardonnay, über-chic bars, clubs or jazz venues, Melbourne has it all.
Melbourne has a lively passion for social eating and drinking, which is reflected in the thousands of restaurants serving up gastronomic experiences from around the world. Everywhere you look you will uncover a vast array of fashionable cafes, where you can enjoy Melbourne's existential coffee culture to the fullest.
It is a leading financial centre in the Asia-Pacific region, and ranks among the top 30 cities in the world in the Global Financial Centres Index. Referred to as Australia’s “cultural capital”, it is the birthplace of Australian impressionism, Australian rules football, the Australian film and television industries, and Australian contemporary dance such as the Melbourne Shuffle.
Melbourne rates highly in education, entertainment, health care, research and development, tourism and sport, making it the world’s most livable city according to the Economist Intelligence Unit. It is recognized as a UNESCO City of Literature and a major centre for street art, music and theatre.
Why to attend???
The Australian pharmaceuticals industry includes biotechnology firms, bio-medical research, originator and generic medicines companies and service-related segments including wholesaling and distribution. In recent years, the Australian pharma industry has been characterized by a more competitive market; significant advancements in technology; constrained budgets; major reform; and increasing scrutiny from payers, regulators and the community. The industry employed approximately 16,500 people in manufacturing and spent around $404 million on pharmaceutical manufacturing R&D in 2011-12. Sales of complementary medicines are worth around $2 billion a year. This has led to pharmaceutical companies having to reassess their business models to ensure they remain responsive.
Who should attend???
With members from around the world focused on learning about Pharmaceutics and Drug Delivery Systems and the most recent techniques, developments, and the newest updates in this field; Target audience expected for this conference include Pharmaceutical Industries, Drug Delivery Systems research institutes, Pharmaceutical Manufacturing Companies, Pharmaceutical Faculty, Drug Delivery Systems Faculty, Pharmaceutical and Drug Delivery Systems Associations and Societies, Pharmaceutical Researchers, Pharmaceutical & Drug Delivery Systems students, scientists, Business Entrepreneurs, Consultancies offering Pharmaceutical & Drug Delivery Systems courses and many more.
Societies Associated with Pharmaceutical Research:-
Australian Society for Medical Research (ASMR)
Industries Associated with Pharmaceutical Research:-
List of Pharmaceutical Companies in Melbourne:
List of Pharmaceutical Companies in Australia:
List of Pharmaceutical Companies in the World:
Revenue in billion U.S dollars
Market Value on Pharmaceutical Research:-
The Australian Pharmaceutical industry is a major high tech industry, with exports of $3.89 billion in 2012-13. The industry employed 15,463 people in manufacturing and the manufacturing sector spent $404 million on product manufacturing R&D in 2011-12. In 2012-13, the pharmaceuticals industry received $7.1 billion from the Pharmaceutical Benefits Scheme (PBS) sale.
The market share of the top ten was:
The Markets Report examines over various markets in terms of economic development, value of U.S. exports, aging populations, per capita pharmaceutical spending, degree of price controls, intellectual property protection and other factors that contribute to pharmaceutical demand growth
The global active pharmaceutical ingredients market is expected to reach USD 213.97 Billion by 2021 from USD 157.95 Billion in 2016, growing at a CAGR of 6.3% from 2016 to 2021. The factors driving market growth include increasing incidence of chronic diseases, rising prevalence of cancer, technological advancements in API manufacturing, growing importance of generics, rapidly increasing geriatric population, increase in abbreviated new drug applications (ANDA) and increasing uptake of biopharmaceuticals
The global nanotechnology market should reach $90.5 billion by 2021 from $39.2 billion in 2016 at a compound annual growth rate (CAGR) of 18.2%, from 2016 to 2021. The global nanocomposite market, in value terms, should reach $5.3 billion by 2021 from $1.6 billion in 2016 at a compound annual growth rate (CAGR) of 26.7%, from 2016 to 2021.
Pharmaceutical Spending – Global Market
Market Growth of Pharmaceutical Research in the last and upcoming ten years
Pharmaceuticals are one of the world's most profitable industries. During the last 30 years, the industry has spent billions of dollars on research and reaped billions in return. In 2008 alone, the pharmaceutical industry sold $773 billion in products worldwide-a number that has consistently grown for the past 8 years and is projected to increase again by 2.5 to 3.5 percent in 2017, according to the drug market research firm IMS Health.
But the process that turns research dollars into medicines is a slow and often arduous one. It now takes an average of 12 to 15 years and up to $1.7 billion for a drug to go from discovery to market, according to The Pharmaceutical Research and Manufacturers of America. And despite all the time and money invested, only a handful of drugs are approved by the FDA each year.
The arduous drug approval process reveals a central fact about Big Pharma: it's one of the most intensely regulated industries in the world. The U.S. Food and Drug Administration (FDA) and its European Union counterpart, the European Medicines Agency (EMEA), govern every aspect of a drug's development-from chemicals used in the drug and clinical study instructions, called protocols, to packaging components and marketing materials. This strict oversight is meant to protect patient safety, and pharma companies take regulatory oversight seriously. The constant pressure to adhere to government mandates shapes every aspect of a pharma firm's organization, operations, and culture. For example, drug companies maintain powerful regulatory affairs divisions-the departments that deal with government agencies-and they tend to be risk-averse.
Funds allotted to Pharmaceutical Research:-
Pharma companies have traditionally funded their internal R&D efforts totally on their own by investing 15% or more of their top line revenues to pay for these endeavours’. In addition, in order to tap into R&D going on outside their companies, pharma has financially supported external R&D efforts in deals with small biotech companies, research institutes, and universities. In fact, as funding for agencies like the NIH has stagnated over recent years, pharma has become an important source of funds to support early stage research.
The R&D Funding Forecast notes that there is a continuing shift in where R&D investments are being made, with fewer in the U.S. and Europe and more in Asian countries. The U.S. now accounts for less than a third of global spending, while Europe’s 34 countries account for less than 22% and Asian countries account for nearly 40%, a trend that has continued for the past five years. This trend is expected to continue through the end of the decade with China’s R&D investments surpassing those of the U.S. by about 2022.
Despite R&D budgets in the billions of dollars, pharma is now seeking to supplement their internal R&D investments with outside funding. One source has been major foundations. The recent Cystic Fibrosis Foundation investment of $58 million into Pfizer R&D to support new research into areas for this disease is a perfect example. The justification for such deals is that pharma companies have a proven R&D track record for delivering new medicines, and the foundations feel that, by tapping into these scientists, they can maximize their chances for getting breakthrough medications.
Non-Federal Research Associations and Foundations:
Pharmacy research funding
Harold and Marjorie Moss Charitable Trust: -
This charitable trust awards funds for pharmacy training at undergraduate, postgraduate and doctorate level.
The Leverhulme Trade Charities Trust:-
The Leverhulme Trade Charities Trust makes grants for the benefit of chemists, commercial travellers and grocers. Pharmacists are able to apply for undergraduate and postgraduate bursaries.
The National Pharmacy Association:-
The National Pharmacy Association Health Education Foundation offers a bursary intended to support community pharmacists who wish to develop their skills to undertake research relating to community pharmacy practice.
The United Kingdom Clinical Pharmacy Association:-
The UKCPA offer a number of annual awards for various aspects of clinical practice, patient safety and IT.
Members Associated with Pharmaceutical Research:-
In regard to Industrial personnel:
Clinical Development and medical Jobs:-
Manufacturing and Quality Assurance Jobs:-
Business Operations Jobs:-
Apart from the industrial personnel where most of the research work is done, other research communities include:-