2nd International Conference on Stem Cells Research, Cell and Gene Therapy is gladdened to invite all the contributors all over the world to be the part of the honoured culmination which will be held on April 23-24, 2021. This conference is prepared for an energizing and enlightening meeting program including discrete techniques, protocols, unalike sessions and various innovative approaches about stem cells research ,cell and gene therapy ,which hopes to join Professors, Researchers and Technocrats all over the world and share/ gain their immense experiences in the field of “Stem Cells Research, Cell and gene Therapy”.
As we know its being a very inclining subject at present in modern technology which gives a brief explanation on stem cell development their isolation and culture experimental technologies and optical molecular imaging , positron emission tomography and computed tomography. Cell therapy offers a new programme that supports the introduction of new and active cells to restore previously damaged or deteriorated tissue- and organ structures. As such, in recent days, cell therapy has been identified as most important field in the treatment of human disease.
Session-1: Stem cells Stem cells are undifferentiated or partially differentiated cells that can vary into different types of cells where they are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells They exist to refill rapidly lost cell types and are multi potent or unipotent, meaning they only transform into a few cell types or one cell type. The first therapy using stem cells was a bone marrow transplant performed by French oncologist Georges Mathé in 1958 on five workers at the VinÄa Nuclear Institute in Yugoslavia who had been attacked by a very critical accident, where they all survived.
Session-2: Properties of stem cells The classical derivation of a stem cell acquires that it possesses two properties:
Self-renewal: The ability to go through various cycles of cell growth and cell division, also called as cell proliferation, which helps in maintaining the undifferentiated state. Two mechanisms ensure that a stem cell population is maintained:
1. Asymmetric cell division: A stem cell divides into one mother cell, which is similar to the original stem cell, and other daughter cell, which is transformed. When a stem cell self-restore, it divides and does not disrupt the undifferentiated state. This self-restored demands control of cell cycle as well as upkeep of multipotency, which all depends on the stem cell.
2. Stochastic differentiation: When one stem cell grows and divides into two different daughter cells, another stem cell undergoes mitosis and forms two stem cells similar to the original.Stem cells use telomerase, a protein that restores telomeres, to protect their DNA and extend their cell division limit.
Potency: The capacity to transform into specialized cell types. In the precise manner, this requires stem cells to be either totipotent or pluripotent—to be able to give rise to any mature cell type, although multipotent or unipotent progenitor cells are sometimes referred to as stem cells. Apart from this, it is said that stem cell function is regulated in a feedback mechanism.
Session-3: Mesenchyme stem cells Mesenchymal stem cells (MSC) are known to be multipotent, which are only seen in adult tissues like in the muscle, liver, bone marrow. Mesenchymal stem cells usually function as structural support in various organs as mentioned above, and control the movement of substances. MSC can differentiate into various cell categories as an instance of adipocytes, osteocytes, and chondrocytes, derived by the mesodermal layer. Whereas the mesoderm layer provides an increase to the body’s skeletal elements, such as relating to the cartilage or bone. These are well-known to be essential for regenerative medicine. Since they are easily isolated and obtain high yield, high plasticity, which makes able to facilitate inflammation and encourage cell growth, cell differentiation, and restoring tissue.
Session-4: Gene therapy Gene therapy is a procedure that uses genes to treat or prevent disease. It is designed to introduce genetic material into cells to remunerate for abnormal genes or to make a beneficial protein. If a mutated gene causes a necessary protein to be faulty, gene therapy may be able to introduce a normal copy of the gene to renew the function of the protein. The concept of gene therapy is to fix a genetic problem at its source. This strategy is referred to as gene replacement therapy and is enrolled to treat inherited retinal diseases.
Session-5: Types of gene therapy Gene therapy may be classified into two types:
In germline gene therapy (GGT), germ cells (sperm or egg cells) are revised by the introduction of functional genes into their genomes. Revising a germ cell causes all the organism's cells to contain the modified gene. The change is hence heritable and passed on to later generations.
Session-6: Vectors Gene therapy utilizes the delivery of DNA into cells, which can be fulfilled by several methods. The two major categories
Viral methods: All viruses bind to their hosts and introduce their genetic material into the host cell as part of their replication cycle. This genetic material contains basic procedures of how to produce more copies of these viruses, hacking the body's normal production machinery to serve the needs of the virus. The host cell will carry out these procedures and produce additional copies of the virus, leading to more and more cells becoming infected. Some types of viruses insert their genome into the host's cytoplasm, but do not actually enter the cell. Others penetrate the cell membrane disguised as protein molecules and enter the cell.
Human Pluripotent Stem Cells (hPSCs) are characterized by their capacity to self-renew and separate into any cell type of the human body. To fully utilize potential of hPSCs for translational research and clinical applications, it is critical to develop rigorous cell separation protocols under feeder-free conditions that are efficient, reproducible, and versatile for high-throughput projects. Focusing on neural change of hPSCs, here we describe robust small molecule-based procedures that generate neural stem cells (NSCs) in less than seven days under chemically defined conditions. These protocols can be utilized to dissect the mechanisms of neural lineage entry and to further develop systematic protocols that produce the cellular diversity of the central nervous system at industrial scale. The most notable type of Pluripotent stem cells is the embryonic stem cell. However, since the generation of embryonic stem cells involves destruction of the pre-implantation stage embryo, there has been a lot of debate surrounding their use. Further, because embryonic stem cells can only be derived from embryos, it has so far not been possible to make patient-matche
Stem cells have furnished much hope by promising to greatly extend the numbers and range of patients who could benefit from transplants, and to deliver cell replacement therapy to treat debilitating diseases like diabetes, Parkinson's and Huntington's disease. The issue of stem cell research is politically charged, prompting biologists to begin engaging in ethical debates, and creating in the general public an high level of interest in this aspect of biology.
The focal scope of stem cells that covers wide range of Cellular origin of cancer stem cells ,Genetic constraints, and also epigenetic modifications, that influence growth process and cancer stem cells as therapeutic targets , mathematical models of cancer cell evolution and mechanisms of survival, embryonic Stem Cells, Signaling pathways/factors regulating and/or initiating ESC/iPS cells pluripotency and differentiation , Stem cell transplantation and technologies that will maintain, improve or restore the function of diseased organs, Gene therapies for inherited diseases.
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2nd International Conference on Stem Cell Research, Cell and Gene Therapy
April 23-24, 2021 | Tokyo, Japan
Young Scientist Awards at Stem Cell 2021 for the Best researches in Stem Cell Research,
Cell and Gene Therapy
Meetings International is announcing Young Scientist Awards through 2nd International Conference on Stem Cell Research, Cells and Gene Therapy (Stem Cell 2021) which is scheduled at Tokyo, Japan during April 23-24, 2021. This Stem Cell Research Conference focuses on “Bridging the Gap from Basic cell Sciences to Advanced Cellular Therapies for a Better life”.
Stem cell Research 2021 and upcoming conferences will recognise participants who have significantly added value to the scientific community of environmental science and provide them outstanding Young Scientist Awards. The Young Scientist Award will provide a strong professional development opportunity for young researches by meeting experts to exchange and share their experiences at our international conferences.
Stem cell Research 2021 focuses mainly on Cell Therapy, Gene Therapy, Molecular Medicine, Immunotherapy, Genetic Medicine. Stem Cell conference operating committee is providing a platform for all the budding young researchers, young investigators, post-graduate/Master students, PhD. students and trainees to showcase their research and innovation.
Young Scientists, faculty members, post-doctoral fellows, PhD scholars and bright Final Year MSc and M.Phil. candidates. Persons from Scientific Industry can also participate.
Benefits: The Young Scientist Feature is a platform to promote young researchers in their respective area by giving them a chance to present their achievements and future perspectives.
Conditions of Acceptance:
To receive the award, the awardee must submit the presentation for which the award is given, for publication at the website, along with author permission. Failure to submit the PPT, and permission within the designated timeframe will result in forfeiture of award.
Official announcement of the recipients will occur after the completion of Stem Cell Conference.
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